GLP - 1 AND GIP RECEPTOR AGONISTS EXAM QUESTIONS AND ANSWERS 100% CORRECT

GLP-1 Receptor Agonist (GLP-1 RA) action - ANSWER"incretin mimetic" increases insulin release with food slows gastric emptying promotes satiety suppresses glucagon GLP-1 RA names - ANSWERexenatide (Byetta) exenatide XR (Bydureon) liraglutide (Victoza) dulaglutide (Trulicity) lixisenatide (Adlyxin) semaglutide (Ozempic) (Rybelsus - oral tablet) exenatide (Byetta) daily dosage range - ANSWER5 and 10 mcg BID which GLP-1 RA is approved for pediatrics 10-17 yrs - ANSWERexenatide XR (Bydureon) liraglutide (Victoza) GLP-1 RA side effects - ANSWERnausea, vomiting wt loss injection site reactions **Report signs of acute pancreatitis (severe abdominal pain, vomiting), stop med** increase dose monthly to achieve targets Dual Incretin Agonist benefits - ANSWERlowers A1c ~1.8-2.4% wt loss of 7-13% of body wt at max dose GLP-1 RA black box warning - ANSWERthyroid C-cell tumor warning (avoid if family hx of medullary thyroid tumor) GLP-1 RA benefits - ANSWERlowers A1c 0.5-1.6% wt loss of 4-6% of body wt Dual Incretin Agonist action - ANSWERcombines both GLP-1 and GIP incretins same action profile as GLP-1 RA (increases insulin release with food, slows gastric emptying, promotes satiety, suppresses glucagon), with more intensive action profile