KPH Kalinga Pharmacy Entranceination Exam
1. What is the primary purpose of chemical bonding in pharmaceutical
chemistry?
a) To determine the pharmacokinetics of drugs
b) To understand molecular stability and reactivity
c) To design drug delivery systems
d) To analyze drug efficacy
Answer: b) To understand molecular stability and reactivity
Explanation: Chemical bonding influences the stability, reactivity, and
properties of molecules, which is essential in designing and
understanding pharmaceutical compounds.
2. Which of the following is an example of an inorganic compound
commonly used in pharmacy?
a) Aspirin (acetylsalicylic acid)
b) Sodium chloride
c) Paracetamol
d) Penicillin
Answer: b) Sodium chloride
Explanation: Sodium chloride is an inorganic compound widely used as
a saline solution, whereas the other options are organic compounds.
, KPH Kalinga Pharmacy Entranceination Exam
3. Stereochemistry is crucial in pharmaceuticals because:
a) It affects drug solubility
b) It influences the drug's biological activity
c) It determines the drug's color
d) It changes the drug's pH
Answer: b) It influences the drug's biological activity
Explanation: The stereochemistry of a molecule can alter how it
interacts with biological targets, affecting efficacy and safety.
4. Which functional group is characterized by a carbon double-bonded
to an oxygen atom and single-bonded to a hydroxyl group?
a) Ketone
b) Alcohol
c) Carboxylic acid
d) Ester
Answer: c) Carboxylic acid
Explanation: The carboxylic acid group contains a carbonyl group (C=O)
and a hydroxyl group (-OH) attached to the same carbon atom.
5. The term ADME in pharmacokinetics refers to:
, KPH Kalinga Pharmacy Entranceination Exam
a) Absorption, Distribution, Metabolism, Excretion
b) Activation, Duration, Metabolism, Elimination
c) Absorption, Delivery, Metabolism, Efficacy
d) Administration, Distribution, Maintenance, Excretion
Answer: a) Absorption, Distribution, Metabolism, Excretion
Explanation: ADME describes the four key processes drugs undergo
within the body influencing their pharmacokinetic profile.
6. Drug-receptor interactions primarily involve:
a) Covalent bonding to DNA
b) Non-specific binding to cell membranes
c) Specific binding to receptor sites to produce a response
d) Physical mixing without chemical bonding
Answer: c) Specific binding to receptor sites to produce a response
Explanation: Drugs exert their effects mainly through specific
interactions with receptors, triggering physiological responses.
7. Which analytical technique is most suitable for separating complex
mixtures based on polarity?
a) Spectroscopy
, KPH Kalinga Pharmacy Entranceination Exam
b) Chromatography
c) Titration
d) Gravimetric analysis
Answer: b) Chromatography
Explanation: Chromatography separates compounds based on their
affinity for stationary and mobile phases, often related to polarity.
8. Standardization of pharmaceutical products ensures:
a) Consistent quality and potency across batches
b) Increased shelf-life only
c) Decreased manufacturing costs
d) Faster drug approval times
Answer: a) Consistent quality and potency across batches
Explanation: Standardization verifies that each batch meets quality
specifications, ensuring safety and efficacy.
9. Which principle is fundamental in drug formulation from a
biopharmaceutics perspective?
a) Maximize drug toxicity
b) Optimize drug release and absorption
1. What is the primary purpose of chemical bonding in pharmaceutical
chemistry?
a) To determine the pharmacokinetics of drugs
b) To understand molecular stability and reactivity
c) To design drug delivery systems
d) To analyze drug efficacy
Answer: b) To understand molecular stability and reactivity
Explanation: Chemical bonding influences the stability, reactivity, and
properties of molecules, which is essential in designing and
understanding pharmaceutical compounds.
2. Which of the following is an example of an inorganic compound
commonly used in pharmacy?
a) Aspirin (acetylsalicylic acid)
b) Sodium chloride
c) Paracetamol
d) Penicillin
Answer: b) Sodium chloride
Explanation: Sodium chloride is an inorganic compound widely used as
a saline solution, whereas the other options are organic compounds.
, KPH Kalinga Pharmacy Entranceination Exam
3. Stereochemistry is crucial in pharmaceuticals because:
a) It affects drug solubility
b) It influences the drug's biological activity
c) It determines the drug's color
d) It changes the drug's pH
Answer: b) It influences the drug's biological activity
Explanation: The stereochemistry of a molecule can alter how it
interacts with biological targets, affecting efficacy and safety.
4. Which functional group is characterized by a carbon double-bonded
to an oxygen atom and single-bonded to a hydroxyl group?
a) Ketone
b) Alcohol
c) Carboxylic acid
d) Ester
Answer: c) Carboxylic acid
Explanation: The carboxylic acid group contains a carbonyl group (C=O)
and a hydroxyl group (-OH) attached to the same carbon atom.
5. The term ADME in pharmacokinetics refers to:
, KPH Kalinga Pharmacy Entranceination Exam
a) Absorption, Distribution, Metabolism, Excretion
b) Activation, Duration, Metabolism, Elimination
c) Absorption, Delivery, Metabolism, Efficacy
d) Administration, Distribution, Maintenance, Excretion
Answer: a) Absorption, Distribution, Metabolism, Excretion
Explanation: ADME describes the four key processes drugs undergo
within the body influencing their pharmacokinetic profile.
6. Drug-receptor interactions primarily involve:
a) Covalent bonding to DNA
b) Non-specific binding to cell membranes
c) Specific binding to receptor sites to produce a response
d) Physical mixing without chemical bonding
Answer: c) Specific binding to receptor sites to produce a response
Explanation: Drugs exert their effects mainly through specific
interactions with receptors, triggering physiological responses.
7. Which analytical technique is most suitable for separating complex
mixtures based on polarity?
a) Spectroscopy
, KPH Kalinga Pharmacy Entranceination Exam
b) Chromatography
c) Titration
d) Gravimetric analysis
Answer: b) Chromatography
Explanation: Chromatography separates compounds based on their
affinity for stationary and mobile phases, often related to polarity.
8. Standardization of pharmaceutical products ensures:
a) Consistent quality and potency across batches
b) Increased shelf-life only
c) Decreased manufacturing costs
d) Faster drug approval times
Answer: a) Consistent quality and potency across batches
Explanation: Standardization verifies that each batch meets quality
specifications, ensuring safety and efficacy.
9. Which principle is fundamental in drug formulation from a
biopharmaceutics perspective?
a) Maximize drug toxicity
b) Optimize drug release and absorption
