Candidate surname Other names
Centre Number Candidate Number
Paper
B ■ ■
Advanced
PAPER 1: Advanced Biochemistry, Microbiology and Genetics
Marks
Scientific calculator, HB pencil, ruler
Instructions
• Use black ink or ball‑point pen.
centre number and candidate number.
Answer the questions in the spaces provided –
there may be more space than you need.
Information
• The total mark for this paper is 90.
– use this as a guide as to how much time to spend on each question.
In question(s) marked with an asterisk (*), marks will be awarded for your ability to structure
your answer logically showing how the points that you make are related or follow on from
each other where appropriate.
Advice
• Read each question carefully before you start to answer it.
• Check your answers if you have time at the end.
Turn over
, Answer ALL questions.
Some questions must be answered with a cross in a box . If you change your mind about an
answer, put a line through the box and then mark your new answer with a cross .
1 Blood is pumped around the body in blood vessels to supply cells with nutrients and
oxygen.
(a) Which box in each row of the table shows where endothelial cells and valves are
found?
(2)
Type of blood vessel
Features of
blood vessels both capillaries capillaries neither capillaries
veins only
and veins only nor veins
Endothelial cells
Valves
(b) Nutrients and oxygen pass into cells from tissue fluid.
Explain how tissue fluid is formed.
(2)
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(Total for Question 1 = 4 marks)
2
■■■■
,2 Glucose is a monosaccharide that is found in sucrose, amylose and amylopectin.
(a) Sucrose is made from glucose and one other molecule.
Which row of the table gives the name of this molecule and the type of reaction that
joins the two molecules together?
(1)
A fructose condensation
B fructose hydrolysis
C
galactose condensation
D
galactose hydrolysis
(b) Compare and contrast the structure of amylose and amylopectin.
(3)
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(Total for Question 2 = 4 marks)
3
■■■■ Turn over
, 3 Viruses can replicate using the lytic cycle.
Viruses can be grown in a laboratory by culturing them with appropriate cells.
(a) Explain why viruses have to be cultured with ‘appropriate cells’.
(2)
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(b) The graph shows the changes in the number of viruses after they had been added to the
cells.
8
7
Log10 number
of viruses 6
5
4
0 20 40 60 80 100
Time after adding viruses to the cells / min
4
■■■■
Centre Number Candidate Number
Paper
B ■ ■
Advanced
PAPER 1: Advanced Biochemistry, Microbiology and Genetics
Marks
Scientific calculator, HB pencil, ruler
Instructions
• Use black ink or ball‑point pen.
centre number and candidate number.
Answer the questions in the spaces provided –
there may be more space than you need.
Information
• The total mark for this paper is 90.
– use this as a guide as to how much time to spend on each question.
In question(s) marked with an asterisk (*), marks will be awarded for your ability to structure
your answer logically showing how the points that you make are related or follow on from
each other where appropriate.
Advice
• Read each question carefully before you start to answer it.
• Check your answers if you have time at the end.
Turn over
, Answer ALL questions.
Some questions must be answered with a cross in a box . If you change your mind about an
answer, put a line through the box and then mark your new answer with a cross .
1 Blood is pumped around the body in blood vessels to supply cells with nutrients and
oxygen.
(a) Which box in each row of the table shows where endothelial cells and valves are
found?
(2)
Type of blood vessel
Features of
blood vessels both capillaries capillaries neither capillaries
veins only
and veins only nor veins
Endothelial cells
Valves
(b) Nutrients and oxygen pass into cells from tissue fluid.
Explain how tissue fluid is formed.
(2)
............................................................................................................................. .. ............................................................................................................................. .. ......................
..................................................................................................... .......................... ............................................................................................................................. .. ......................
......................................................................... ...................................................... ............................................................................................................................. .. ......................
............................................................................................................................. .. ............................................................................................................................. .. ......................
............................................................................................................................. .. ................................................................................................... ............................ ......................
............................................................................................................................. .. ............................................................................................................................. .. ......................
(Total for Question 1 = 4 marks)
2
■■■■
,2 Glucose is a monosaccharide that is found in sucrose, amylose and amylopectin.
(a) Sucrose is made from glucose and one other molecule.
Which row of the table gives the name of this molecule and the type of reaction that
joins the two molecules together?
(1)
A fructose condensation
B fructose hydrolysis
C
galactose condensation
D
galactose hydrolysis
(b) Compare and contrast the structure of amylose and amylopectin.
(3)
............................................................................................................................. .. ............................................................................................................................. .. ......................
..................................................................................................... .......................... ............................................................................................................................. .. ......................
............................................................................................................................. .. ............................................................................................................................. .. ......................
............................................................................................................................. .. ................................................................................................... ............................ ......................
............................................................................................................................. .. ....................................................................... ........................................................ ......................
............................................................................................................................. .. ........................................... .................................................................................... ......................
............................................................................................................................. .. ............................................................................................................................... ......................
.................................................................................................................... ........... ............................................................................................................................. .. ......................
............................................................................................................................. .. ............................................................................................................................. .. ......................
(Total for Question 2 = 4 marks)
3
■■■■ Turn over
, 3 Viruses can replicate using the lytic cycle.
Viruses can be grown in a laboratory by culturing them with appropriate cells.
(a) Explain why viruses have to be cultured with ‘appropriate cells’.
(2)
............................................................................................................................. .. ............................................................................................................................. .. ......................
..................................................................................................... .......................... ............................................................................................................................. .. ......................
............................................................................................................................. .. ............................................................................................................................. .. ......................
............................................................................................................................. .. ................................................................................................... ............................ ......................
............................................................................................................................. .. ....................................................................... ........................................................ ......................
............................................................................................................................. .. ........................................... .................................................................................... ......................
(b) The graph shows the changes in the number of viruses after they had been added to the
cells.
8
7
Log10 number
of viruses 6
5
4
0 20 40 60 80 100
Time after adding viruses to the cells / min
4
■■■■
