Advanced Pharmacology APEA 3P – Study Guide for AANP/ANCC Exams | Real Exam Practice & Key Concepts

3P APEA REAL Exam Study Guide:
Pharmacology
✅ 70 Verified Practice Questions with Correct Answers and
Rationales


1. Which of the following is the drug of choice for initial treatment of
hypertension in a non-black adult with no comorbidities?

 A. Hydrochlorothiazide
 B. Lisinopril
 C. Amlodipine
 D. Metoprolol

✅ Correct Answer: B. Lisinopril
💡 Rationale: ACE inhibitors like Lisinopril are first-line for hypertension unless
contraindicated.



2. What is a major adverse effect of aminoglycosides such as gentamicin?

 A. Hepatotoxicity
 B. Ototoxicity
 C. Nephrolithiasis
 D. Photosensitivity

✅ Correct Answer: B. Ototoxicity
💡 Rationale: Aminoglycosides can cause irreversible hearing loss due to ototoxic effects.



3. Which of the following medications is a rapid-acting insulin?

 A. NPH
 B. Regular insulin
 C. Insulin glargine
 D. Insulin lispro

,✅ Correct Answer: D. Insulin lispro
💡 Rationale: Lispro is a rapid-acting insulin ideal for post-meal glucose control.



4. Which medication is used to treat hyperthyroidism?

 A. Levothyroxine
 B. Methimazole
 C. Liothyronine
 D. Hydrocortisone

✅ Correct Answer: B. Methimazole
💡 Rationale: Methimazole is the preferred antithyroid medication for long-term management
of hyperthyroidism.



5. Which of the following is an alpha-blocker used in the treatment of BPH?

 A. Tamsulosin
 B. Finasteride
 C. Dutasteride
 D. Sildenafil

✅ Correct Answer: A. Tamsulosin
💡 Rationale: Tamsulosin selectively blocks alpha-1 receptors in the prostate, improving urine
flow.



6. A serious adverse effect of statin therapy is:

 A. Tachycardia
 B. Hyperkalemia
 C. Rhabdomyolysis
 D. Pancreatitis

✅ Correct Answer: C. Rhabdomyolysis
💡 Rationale: Statins may cause muscle breakdown, leading to rhabdomyolysis, a serious
condition.



7. Which diabetes medication is associated with weight loss?

,  A. Glyburide
 B. Insulin glargine
 C. Liraglutide
 D. Pioglitazone

✅ Correct Answer: C. Liraglutide
💡 Rationale: GLP-1 receptor agonists like Liraglutide promote satiety and can lead to weight
loss.



8. What should be monitored in a patient on long-term corticosteroids?

 A. Blood calcium
 B. Liver enzymes
 C. White blood cells
 D. Blood glucose

✅ Correct Answer: D. Blood glucose
💡 Rationale: Long-term corticosteroids can induce hyperglycemia and insulin resistance.



9. Which medication is used for alcohol withdrawal?

 A. Lorazepam
 B. Naloxone
 C. Disulfiram
 D. Fluoxetine

✅ Correct Answer: A. Lorazepam
💡 Rationale: Benzodiazepines like Lorazepam are used to prevent seizures in alcohol
withdrawal.



10. What is the primary use of Atropine?

 A. Lower blood pressure
 B. Treat bradycardia
 C. Induce sleep
 D. Relieve anxiety