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What is pharmacodynamics? - 🧠 ANSWER ✔✔- The biologic, chemical,
and physiologic actions of a particular drug within the body
- What the drug does to the body
- The pharmacodynamics of a drug are responsible for its therapeutic
effects and sometimes adverse effects
What is pharmacokinetics? - 🧠 ANSWER ✔✔- The study of drug movement
throughout the body
- What the body does to the drug
- Absorption, distribution, metabolism, and excretion
What are the four ways that drugs work within the body? - 🧠 ANSWER ✔✔-
Replace or act as a substitute for missing chemicals
- To increase or stimulate certain cellular activities
- To depress or slow cellular activities
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,- To interfere with the functioning of foreign cells
What is the process of pharmacokinetics? (ADME) - 🧠 ANSWER
✔✔Absorption
Distribution
Metabolism
Excretion
What is absorption? - 🧠 ANSWER ✔✔- The movement of the drug from the
site of administration into the bloodstream
- What happens to a drug from the time it is introduced to the body until it
reaches the circulating fluids and tissues
What is distribution? - 🧠 ANSWER ✔✔The movement of the drugs into the
cells and body tissues
What is biotransformation (metabolism)? - 🧠 ANSWER ✔✔- The conversion
of the drug into another substance or substances
- Chemically converts drug so it can be easily removed from body
What is excretion? - 🧠 ANSWER ✔✔- The removal of the drug
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,- Elimination of a drug or its metabolites from the body, most commonly via
kidneys (urine)
How are medications absorbed? - 🧠 ANSWER ✔✔The vast majority of
medications are taken orally and are broken down within the
gastrointestinal tract. Once the medication arrives, it is broken down by
stomach acids before it passes through the liver and then enters the
bloodstream.
What factors affect absorption of medications? - 🧠 ANSWER ✔✔- Dosage
form
- Route of administration
- Administration site blood flow
- GI function
- Presence of food or other drugs
What is metabolism (biotransformation process)? - 🧠 ANSWER
✔✔Chemical alteration of the drug by the body
What is the first pass effect? - 🧠 ANSWER ✔✔Loss of effectiveness during
the first pass through the liver
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, What is protein binding? How does it relate to distribution? - 🧠 ANSWER
✔✔Protein-bound drugs can't pass through capillary walls until bonds
dissolve, dosages calculated based on the protein-binding characteristics,
Low "albumin level", more unbound, more toxicity
What is the blood brain barrier? How does it relate to distribution? - 🧠
ANSWER ✔✔Cells in the capillary walls are tightly packed, keeps toxins
and poisons out of the brain
Placenta membrane and lactation, how does it relate to distribution? - 🧠
ANSWER ✔✔Not a barrier like the blood-brain barrier, any drug that can
pass through a membrane can pas through the placenta, always ask if a pt
is pregnant or lactating
What is the hepatic microsomal (P-450 enzyme) system? - 🧠 ANSWER
✔✔Liver metabolism predominately achieved by specific liver enzymes
called cytochrome P-450
What is pharmacogenomics? - 🧠 ANSWER ✔✔Genotyping for allleles that
alllow for abnormal metabolism of certain drugs by the P-450 sytem
What is the process of excretion? - 🧠 ANSWER ✔✔Elimination of a drug or
its metabolites from the body, most commonly via kidneys (urine)
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