1. Adaptive cellular mechanisms function to:
A. Treat disease
B. Protect cells from injury
C. Prevent cellular aging
D. Speed up cell death
o Answer: B
o Rationale: Adaptations (e.g., hypertrophy,
hyperplasia) are reversible changes that allow
cells to withstand stress and avoid injury ﹣ they
do not treat disease or affect aging directly.
(Pathophysiology Multiple Choice Questions
Flashcards - Quizlet)
2. Which of the following is NOT an aspect of
pathophysiology?
A. Causes
B. Pathogenesis
C. Morphological changes
D. Therapeutic treatment
o Answer: D
o Rationale: Pathophysiology studies causes,
mechanisms (pathogenesis), and structural
changes; therapy is clinical management, not
part of pathophysiology per se. ([PDF] pharm. d
2nd year pathophysiology - mcq - dr. naitik
trivedi)
,3. A characteristic feature of necrosis but not
apoptosis is:
A. Cell shrinkage
B. Chromatin condensation
C. Inflammation
D. DNA laddering
o Answer: C
o Rationale: Necrosis elicits an inflammatory
response due to cell membrane rupture, whereas
apoptosis is immunologically silent. ([PDF]
pharm. d 2nd year pathophysiology - mcq - dr.
naitik trivedi)
4. Which physical agent causes cell injury by
denaturing proteins and disrupting membranes?
A. Immune complexes
B. Radiation
C. Hypoxia
D. Hot surface
o Answer: D
o Rationale: Thermal injury (heat) directly
damages proteins and lipids, leading to
membrane disruption. ([PDF] pharm. d 2nd year
pathophysiology - mcq - dr. naitik trivedi)
5. Hyperplasia is defined as:
A. Increase in cell size
B. Increase in cell number
, C. Conversion of one cell type to another
D. Programmed cell death
o Answer: B
o Rationale: Hyperplasia is proliferative—
increased cell numbers in response to stimulus.
([PDF] pharm. d 2nd year pathophysiology - mcq
- dr. naitik trivedi)
6. Which adaptation is reversible and involves a
change in phenotype?
A. Hypertrophy
B. Metaplasia
C. Necrosis
D. Dysplasia
o Answer: B
o Rationale: Metaplasia is reversible replacement
of one adult cell type with another, often in
response to chronic irritation. ([PDF] pharm. d
2nd year pathophysiology - mcq - dr. naitik
trivedi)
7. The first stage of acute inflammation is:
A. Fibrosis
B. Chemotaxis
C. Vasodilation
D. Phagocytosis
o Answer: C
A. Treat disease
B. Protect cells from injury
C. Prevent cellular aging
D. Speed up cell death
o Answer: B
o Rationale: Adaptations (e.g., hypertrophy,
hyperplasia) are reversible changes that allow
cells to withstand stress and avoid injury ﹣ they
do not treat disease or affect aging directly.
(Pathophysiology Multiple Choice Questions
Flashcards - Quizlet)
2. Which of the following is NOT an aspect of
pathophysiology?
A. Causes
B. Pathogenesis
C. Morphological changes
D. Therapeutic treatment
o Answer: D
o Rationale: Pathophysiology studies causes,
mechanisms (pathogenesis), and structural
changes; therapy is clinical management, not
part of pathophysiology per se. ([PDF] pharm. d
2nd year pathophysiology - mcq - dr. naitik
trivedi)
,3. A characteristic feature of necrosis but not
apoptosis is:
A. Cell shrinkage
B. Chromatin condensation
C. Inflammation
D. DNA laddering
o Answer: C
o Rationale: Necrosis elicits an inflammatory
response due to cell membrane rupture, whereas
apoptosis is immunologically silent. ([PDF]
pharm. d 2nd year pathophysiology - mcq - dr.
naitik trivedi)
4. Which physical agent causes cell injury by
denaturing proteins and disrupting membranes?
A. Immune complexes
B. Radiation
C. Hypoxia
D. Hot surface
o Answer: D
o Rationale: Thermal injury (heat) directly
damages proteins and lipids, leading to
membrane disruption. ([PDF] pharm. d 2nd year
pathophysiology - mcq - dr. naitik trivedi)
5. Hyperplasia is defined as:
A. Increase in cell size
B. Increase in cell number
, C. Conversion of one cell type to another
D. Programmed cell death
o Answer: B
o Rationale: Hyperplasia is proliferative—
increased cell numbers in response to stimulus.
([PDF] pharm. d 2nd year pathophysiology - mcq
- dr. naitik trivedi)
6. Which adaptation is reversible and involves a
change in phenotype?
A. Hypertrophy
B. Metaplasia
C. Necrosis
D. Dysplasia
o Answer: B
o Rationale: Metaplasia is reversible replacement
of one adult cell type with another, often in
response to chronic irritation. ([PDF] pharm. d
2nd year pathophysiology - mcq - dr. naitik
trivedi)
7. The first stage of acute inflammation is:
A. Fibrosis
B. Chemotaxis
C. Vasodilation
D. Phagocytosis
o Answer: C
