NUR2140C Nursing Pharmacotherapeutics
4.0 Credits
Complete Final Exam (Qns & Ans)
2025
Question 1 (Multiple Choice)
Case: A 68-year-old patient with chronic kidney disease (CKD)
and symptoms of pneumonia is admitted for treatment. The nurse
is reviewing the pharmacotherapeutic regimen and notes that one
antibiotic requires dosage adjustment due to its renal clearance.
Question: Which antibiotic is most likely to require a dosage
adjustment in this patient?
A. Azithromycin
B. Levofloxacin
©2025
,C. Clindamycin
D. Doxycycline
Correct ANS: B. Levofloxacin
Rationale: Levofloxacin is primarily excreted by the kidneys.
In patients with CKD, dosage must be adjusted to prevent drug
accumulation and potential toxicity. Other options are either less
dependent on renal clearance or use alternative metabolic
pathways.
---
Question 2 (Multiple Choice)
Case: A 72-year-old patient with atrial fibrillation is
transitioning from warfarin to a novel oral anticoagulant (NOAC).
The nurse is reviewing potential pharmacotherapeutic concerns.
Question: Which factor is the most critical for assessing drug-
drug interaction risk during this transition?
A. Prothrombin time response
B. CYP enzyme involvement
C. International Normalized Ratio (INR)
©2025
,D. Bleeding risk score
Correct ANS: B. CYP enzyme involvement
Rationale: Many oral anticoagulants (and warfarin) are
metabolized by cytochrome P450 enzymes. Understanding CYP
enzyme involvement helps anticipate interference from other
medications and reduce the risk of adverse interactions during
therapy changes.
---
Question 3 (Fill-in-the-Blank)
Statement:
_______ is the pharmacokinetic process responsible for the
transformation of drugs into more water-soluble metabolites,
facilitating their excretion.
Correct ANS: Metabolism
Rationale: Metabolism, primarily occurring in the liver via
cytochrome P450 enzymes, converts drugs into metabolites that
are more water-soluble, allowing easier renal or biliary excretion.
©2025
, ---
Question 4 (Fill-in-the-Blank)
Statement:
A prolonged _______ interval on an electrocardiogram is a
critical indicator for the risk of arrhythmias in patients receiving
medications that affect cardiac repolarization.
Correct ANS: QT
Rationale: The QT interval represents the duration of cardiac
repolarization. Its prolongation is associated with an increased
risk for ventricular arrhythmias such as torsades de pointes,
making it essential for nurses to monitor in patients on
medications known to affect this parameter.
---
Question 5 (True/False)
Statement:
©2025
4.0 Credits
Complete Final Exam (Qns & Ans)
2025
Question 1 (Multiple Choice)
Case: A 68-year-old patient with chronic kidney disease (CKD)
and symptoms of pneumonia is admitted for treatment. The nurse
is reviewing the pharmacotherapeutic regimen and notes that one
antibiotic requires dosage adjustment due to its renal clearance.
Question: Which antibiotic is most likely to require a dosage
adjustment in this patient?
A. Azithromycin
B. Levofloxacin
©2025
,C. Clindamycin
D. Doxycycline
Correct ANS: B. Levofloxacin
Rationale: Levofloxacin is primarily excreted by the kidneys.
In patients with CKD, dosage must be adjusted to prevent drug
accumulation and potential toxicity. Other options are either less
dependent on renal clearance or use alternative metabolic
pathways.
---
Question 2 (Multiple Choice)
Case: A 72-year-old patient with atrial fibrillation is
transitioning from warfarin to a novel oral anticoagulant (NOAC).
The nurse is reviewing potential pharmacotherapeutic concerns.
Question: Which factor is the most critical for assessing drug-
drug interaction risk during this transition?
A. Prothrombin time response
B. CYP enzyme involvement
C. International Normalized Ratio (INR)
©2025
,D. Bleeding risk score
Correct ANS: B. CYP enzyme involvement
Rationale: Many oral anticoagulants (and warfarin) are
metabolized by cytochrome P450 enzymes. Understanding CYP
enzyme involvement helps anticipate interference from other
medications and reduce the risk of adverse interactions during
therapy changes.
---
Question 3 (Fill-in-the-Blank)
Statement:
_______ is the pharmacokinetic process responsible for the
transformation of drugs into more water-soluble metabolites,
facilitating their excretion.
Correct ANS: Metabolism
Rationale: Metabolism, primarily occurring in the liver via
cytochrome P450 enzymes, converts drugs into metabolites that
are more water-soluble, allowing easier renal or biliary excretion.
©2025
, ---
Question 4 (Fill-in-the-Blank)
Statement:
A prolonged _______ interval on an electrocardiogram is a
critical indicator for the risk of arrhythmias in patients receiving
medications that affect cardiac repolarization.
Correct ANS: QT
Rationale: The QT interval represents the duration of cardiac
repolarization. Its prolongation is associated with an increased
risk for ventricular arrhythmias such as torsades de pointes,
making it essential for nurses to monitor in patients on
medications known to affect this parameter.
---
Question 5 (True/False)
Statement:
©2025
