GNRS 576 Pharmacology Test #1
Absorption section - ANS--manner of taking the drug in until it hits the blood move
-onset of drug action is basically determined by means of the price of absorption
-elements that have an effect on absorption: bioavailability, first-bypass impact, meals in the
stomach, presence of other meds, dosage form (ie enteric vs sluggish release)
acetaminophen negative consequences - ANS--overdose or unintended misuse can motive
hepatic necrosis
-3,000-four,000mg in step with day is the max for everyday liver
-2,000mg in step with day is max for damaged liver
acetaminophen antidote - ANS--acetylcysteine
-mechanism of action: prevents hepatotoxic metabolites of acetaminophen from forming
-affected person wishes to take one preliminary loading dose plus 17 greater doses
-if affected person vomits inside an hour of dose they need to take any other
acetaminophen contraindications - ANS--people with hypersensitivity to the med
acetaminophen favored healing effect/warning signs - ANS--reduces moderate to mild pain and
fever
acetaminophen drug to drug interactions - ANS--many pills have acetaminophen so patient
have to watch what meds they are blending to avoid taking an excessive amount of
Acetaminophen mechanism of action - ANS--blocks peripheral pain impulses through inhibition
of prostaglandin synthesis
-antipyretic consequences thru action at the hypothalamus (blocks prostaglandins within the
CNS)
Acetaminophen nursing implications - ANS--display maximum each day dose
Acetaminophen patient training - ANS--teach affected person to evaluate their meds for
acetaminophen to prevent misuse
-do no longer blend acetaminophen and alcohol due to hepatoxicity
additive effects - ANS-blended consequences produced with the aid of the motion of two or
more tablets
damaging outcomes - ANS-symptom produced by using a drug that is injurious to the affected
person
, Bioavailability - ANS--how a whole lot of the med is to be had to the body and what sort of of the
drug we get to apply
-oral tablets are depending on first-skip effect
-oral drugs typically have less than a hundred% bioavailability
-IV pills commonly have one hundred% bioavailability
breakthrough ache - ANS--ache it's being handled with pain remedy but the ache comes again
before it's time for next dose
-ache has "damaged thru remedy"
cancer ache - ANS-pain comes from a increase of cancer pressing on tissues/nerves
capsules - ANS--med balls encased in gelatin shell
-little bits of meds that could dissolve at different charges and are regularly sustained or
prolonged launch
classes of managed subtances - ANS--class I: most likely to be abused & meds we rarely use in
remedy (cocaine, heroine, LSD)
-class II: addictive meds we're going to address extra often in remedy (morphine, codeine,
dilaudid)
-category III: less probably to be abused that category II (Tylenol with codeine)
-category five: least probably to be abused; affected person will experience many different side
results before getting high
chemical call of drug - ANS-medical call based totally at the compound's chemical structure
chewable - ANS--used for kids and other customers which have a tough time swallowing pills
-breakdown of drug begins in the mouth
exceptional route to take meds - ANS--enteral: oral meds which are absorbed in the stomach
and small intestine
-parenteral: injections (intradermal, subcutaneous, IM, IV)
-topical: unfold on body interior or out (eyes, ears, pores and skin, nostril, lungs, rectum,
vagina); inhalants, suppositories, lotions, drops
dissolution - ANS-procedure wherein drug debris have a tendency to dissolve in body fluid
distribution - ANS--delivery of drug through the bloodstream to the website of action
-determined by way of: blood drift to the tissues because blood flow is wanted to transport the
drug, drug needs if you want to go out the vascular system and get out of the blood stream,
drug needs on the way to enter the mobile
-influenced via protein binding
Absorption section - ANS--manner of taking the drug in until it hits the blood move
-onset of drug action is basically determined by means of the price of absorption
-elements that have an effect on absorption: bioavailability, first-bypass impact, meals in the
stomach, presence of other meds, dosage form (ie enteric vs sluggish release)
acetaminophen negative consequences - ANS--overdose or unintended misuse can motive
hepatic necrosis
-3,000-four,000mg in step with day is the max for everyday liver
-2,000mg in step with day is max for damaged liver
acetaminophen antidote - ANS--acetylcysteine
-mechanism of action: prevents hepatotoxic metabolites of acetaminophen from forming
-affected person wishes to take one preliminary loading dose plus 17 greater doses
-if affected person vomits inside an hour of dose they need to take any other
acetaminophen contraindications - ANS--people with hypersensitivity to the med
acetaminophen favored healing effect/warning signs - ANS--reduces moderate to mild pain and
fever
acetaminophen drug to drug interactions - ANS--many pills have acetaminophen so patient
have to watch what meds they are blending to avoid taking an excessive amount of
Acetaminophen mechanism of action - ANS--blocks peripheral pain impulses through inhibition
of prostaglandin synthesis
-antipyretic consequences thru action at the hypothalamus (blocks prostaglandins within the
CNS)
Acetaminophen nursing implications - ANS--display maximum each day dose
Acetaminophen patient training - ANS--teach affected person to evaluate their meds for
acetaminophen to prevent misuse
-do no longer blend acetaminophen and alcohol due to hepatoxicity
additive effects - ANS-blended consequences produced with the aid of the motion of two or
more tablets
damaging outcomes - ANS-symptom produced by using a drug that is injurious to the affected
person
, Bioavailability - ANS--how a whole lot of the med is to be had to the body and what sort of of the
drug we get to apply
-oral tablets are depending on first-skip effect
-oral drugs typically have less than a hundred% bioavailability
-IV pills commonly have one hundred% bioavailability
breakthrough ache - ANS--ache it's being handled with pain remedy but the ache comes again
before it's time for next dose
-ache has "damaged thru remedy"
cancer ache - ANS-pain comes from a increase of cancer pressing on tissues/nerves
capsules - ANS--med balls encased in gelatin shell
-little bits of meds that could dissolve at different charges and are regularly sustained or
prolonged launch
classes of managed subtances - ANS--class I: most likely to be abused & meds we rarely use in
remedy (cocaine, heroine, LSD)
-class II: addictive meds we're going to address extra often in remedy (morphine, codeine,
dilaudid)
-category III: less probably to be abused that category II (Tylenol with codeine)
-category five: least probably to be abused; affected person will experience many different side
results before getting high
chemical call of drug - ANS-medical call based totally at the compound's chemical structure
chewable - ANS--used for kids and other customers which have a tough time swallowing pills
-breakdown of drug begins in the mouth
exceptional route to take meds - ANS--enteral: oral meds which are absorbed in the stomach
and small intestine
-parenteral: injections (intradermal, subcutaneous, IM, IV)
-topical: unfold on body interior or out (eyes, ears, pores and skin, nostril, lungs, rectum,
vagina); inhalants, suppositories, lotions, drops
dissolution - ANS-procedure wherein drug debris have a tendency to dissolve in body fluid
distribution - ANS--delivery of drug through the bloodstream to the website of action
-determined by way of: blood drift to the tissues because blood flow is wanted to transport the
drug, drug needs if you want to go out the vascular system and get out of the blood stream,
drug needs on the way to enter the mobile
-influenced via protein binding
