MSP Final Exam 2025 Questions and
Answers 100% Pass
What are 4 pathologies that fall under the category of spondyloarthropathies? -
✔✔Ankylosing spondylitis
Psoriatic arthritis
Reiter's syndrome
Enteropathic Arthropathy
*Spondyloarthropathies are (local/systemic)* - ✔✔Systemic
Pts with spondyloarthropathies may have inflammation in what other areas of the
body? - ✔✔Eye
Bowl
Genital tract
Skin
A high % of pts with Spondyloarthropathies share what gene? - ✔✔HLA B27 gene
HLA B27 protein is found on the surface of _____ - ✔✔WBCs
What % of the general population has the HLA B27 gene? What % will develop
spondyloarthropathies? - ✔✔8%
2%
*Spondyloarthropathies are (seronegative/seropositive)*
What structurs of the body is affected? - ✔✔Seronegative
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,Spine
*Spondyloarthropathies may be ______ early but then become ________ and __________
as the disease progresses* - ✔✔unilateral
bilateral
symmetrical
*With spondyloarthropathies, few ________ joints are involved
__________ of tendons and fascia will be present* - ✔✔peripheral
inflammation
*what population is susceptible to spondyloarthropathies?* - ✔✔Younger males age 18-
20s
*Compare and contract osteophytes from syndesmophytes* - ✔✔Osteophytes- arise
from the plane of the joint, "east-> west", associated with non-inflammatory joint
diseases
Syndesmophytes- form due to granulomatous tissue calcific depostion, "north-> south",
associated with inflammatory joint diseases/spondyloarthropathies
Ankylosing spondylitis mainly is localized to the _________ and has peripheral joint
involvement in ______ of pts - ✔✔spine
~1/3
What gender is more susceptible to AS? - ✔✔Males
What is the typical age of onset of AS?
Age of DX?
Chance of a sibling having AS? - ✔✔15-30
23 years old
20%
*What is the pathogenesis of AS?* - ✔✔Inflammation of joints- synovial joints develop a
pannus and cartilaginous joints develop granulation tissue
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, Invovlement of spinal ligaments- chronic inflammation of ligaments can result in
granulation tissue deposition
Pannus progresses to *fibrous ankylosis*
Calcification of ligaments and granulation tissue
Fibrous ankylosis progresses to *bony ankylosis*
*What are the common areas of involvement in the body of AS?* - ✔✔SI joint
Spine
Heels
Hips
Shoulders
*What are the clinical characteristics of AS?* - ✔✔Initial Sx may be transient; pts may
complain of only stiffness in joints
Pain and stiffness over SI joints
Late disease may show decreased chest expansion only if costo-transverse ligaments are
affected
*What is enthesopathy?*
What pathology is it associated with? - ✔✔Local ligament or tendon fiber disruption;
reactive bone forms at the end of ligament or tendon
Ankylosing Spondylitis
*How does a pt with AS describe their pain throughout a day?* - ✔✔Pain intensity
maximal morning, evening and night (constant pain due to pannus production)
Relieved by movement
*With AS, progressive spinal fusion will lead to _______ _______* - ✔✔Bony ankylosis
*Advanced AS pts demonstrate what type of posture?* - ✔✔kyphotic posture
What are the laboratory findings for AS? - ✔✔elevated ESR
normal alk phos
COPYRIGHT © 2025 BY EMILLY CHARLOTTE, ALL RIGHTS RESERVED 3
Answers 100% Pass
What are 4 pathologies that fall under the category of spondyloarthropathies? -
✔✔Ankylosing spondylitis
Psoriatic arthritis
Reiter's syndrome
Enteropathic Arthropathy
*Spondyloarthropathies are (local/systemic)* - ✔✔Systemic
Pts with spondyloarthropathies may have inflammation in what other areas of the
body? - ✔✔Eye
Bowl
Genital tract
Skin
A high % of pts with Spondyloarthropathies share what gene? - ✔✔HLA B27 gene
HLA B27 protein is found on the surface of _____ - ✔✔WBCs
What % of the general population has the HLA B27 gene? What % will develop
spondyloarthropathies? - ✔✔8%
2%
*Spondyloarthropathies are (seronegative/seropositive)*
What structurs of the body is affected? - ✔✔Seronegative
COPYRIGHT © 2025 BY EMILLY CHARLOTTE, ALL RIGHTS RESERVED 1
,Spine
*Spondyloarthropathies may be ______ early but then become ________ and __________
as the disease progresses* - ✔✔unilateral
bilateral
symmetrical
*With spondyloarthropathies, few ________ joints are involved
__________ of tendons and fascia will be present* - ✔✔peripheral
inflammation
*what population is susceptible to spondyloarthropathies?* - ✔✔Younger males age 18-
20s
*Compare and contract osteophytes from syndesmophytes* - ✔✔Osteophytes- arise
from the plane of the joint, "east-> west", associated with non-inflammatory joint
diseases
Syndesmophytes- form due to granulomatous tissue calcific depostion, "north-> south",
associated with inflammatory joint diseases/spondyloarthropathies
Ankylosing spondylitis mainly is localized to the _________ and has peripheral joint
involvement in ______ of pts - ✔✔spine
~1/3
What gender is more susceptible to AS? - ✔✔Males
What is the typical age of onset of AS?
Age of DX?
Chance of a sibling having AS? - ✔✔15-30
23 years old
20%
*What is the pathogenesis of AS?* - ✔✔Inflammation of joints- synovial joints develop a
pannus and cartilaginous joints develop granulation tissue
COPYRIGHT © 2025 BY EMILLY CHARLOTTE, ALL RIGHTS RESERVED 2
, Invovlement of spinal ligaments- chronic inflammation of ligaments can result in
granulation tissue deposition
Pannus progresses to *fibrous ankylosis*
Calcification of ligaments and granulation tissue
Fibrous ankylosis progresses to *bony ankylosis*
*What are the common areas of involvement in the body of AS?* - ✔✔SI joint
Spine
Heels
Hips
Shoulders
*What are the clinical characteristics of AS?* - ✔✔Initial Sx may be transient; pts may
complain of only stiffness in joints
Pain and stiffness over SI joints
Late disease may show decreased chest expansion only if costo-transverse ligaments are
affected
*What is enthesopathy?*
What pathology is it associated with? - ✔✔Local ligament or tendon fiber disruption;
reactive bone forms at the end of ligament or tendon
Ankylosing Spondylitis
*How does a pt with AS describe their pain throughout a day?* - ✔✔Pain intensity
maximal morning, evening and night (constant pain due to pannus production)
Relieved by movement
*With AS, progressive spinal fusion will lead to _______ _______* - ✔✔Bony ankylosis
*Advanced AS pts demonstrate what type of posture?* - ✔✔kyphotic posture
What are the laboratory findings for AS? - ✔✔elevated ESR
normal alk phos
COPYRIGHT © 2025 BY EMILLY CHARLOTTE, ALL RIGHTS RESERVED 3
