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FA-BA203 Neurologie samenvatting responsiecollege 2

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Uitgebreide aangekomene van het 2e responsiecollege neurologie waarbij veelvoorkomende toetsvragen besproken werden, veelgemaakte fouten en laatste belangrijke tips en informatie. Hier zijn dus door mij aantekeningen van gemaakt. Perfect ter voorbereiding op je eigen tentamen !

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Institution
Universiteit Utrecht (UU)
Course
FA BA204 Neurologie (FABA203)










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Institution
Universiteit Utrecht (UU)
Study
Farmacie
Course
FA BA204 Neurologie (FABA203)
All documents for this subject (14)

Document information

Uploaded on
April 20, 2025
Number of pages
16
Written in
2024/2025
Type
Summary

Subjects

  • pijn
  • nsaid
  • opioiden
  • mu receptor
  • mor
  • delta
  • kappa
  • orl1
  • serotonine
  • noradrenalien
  • noradrenaline
  • dopamine
  • l dopa
  • sensitatie

Content preview

16-12-2024




RESPONSIECOLLEGE
THEMA 2 PIJN
FA-BA203
16 december 2024
Liesbeth Bijlsma




1




Wat gaat er goed?

Inhoudelijk:

• Werkingsmechanismen NSAID + paracetamol
• Werkingsmechanismen opioiden
• Farmacotherapie nociceptieve pijn (PCM, NSAID, opioïden)




2




1

, 16-12-2024




Wat is nog lastig?
• 55% van de studenten geen zicht op voortgang

• Pijn-modulerende mediatoren + mechanismen
• Eigenschappen opioïden
• Samenstel tussen verschillende sensorische banen
• Farmacotherapie lokale anesthetica
• Neuropatische pijn
• Terminologie veranderingen in pijnperceptie
• Modulatie serotonine systeem
• Behandeling


• Inzicht en diepgang?



3




Overzicht pijn-modulerende
mediatoren




Rang & Dale’s Pharmacology, 8th Edition (2015)

4




2

, 16-12-2024




Wat is nog lastig?
• Pijn-modulerende mediatoren + mechanismen
• Eigenschappen opioïden
• Samenspel tussen verschillende sensorische banen
• Farmacotherapie lokale anesthetica
• Neuropatische pijn
• Terminologie veranderingen in pijnperceptie
• Modulatie serotonine systeem
• Behandeling


• Inzicht en diepgang?


7




Eigenschappen opioïden
Kleine moleculen Neuropeptiden
(monoamines, GABA, Glutamaat) (opioiden)




Endogeen opioïd (o.a. endorfinen)
= peptide, geen monoamine
= genexpressie + eiwitsynthese,
geen enzymatische synthese
= enzymatische afbraak, geen heropname


8




3
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