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Samenvatting FA-BA203 Bloedhersenbarriere passage

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Uitgebreid document waarin alle aspecten behandeld worden om te kunnen beoordelen of een geneesmiddel passief de bloedhersenbarriere zal kunnen passeren of nier, denk aan log P, log D etc. Perfect ter voorbereiding op je tentamen of literatuurverslag!

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Institution
Universiteit Utrecht (UU)
Course
FA BA204 Neurologie (FABA203)











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Institution
Universiteit Utrecht (UU)
Study
Farmacie
Course
FA BA204 Neurologie (FABA203)
All documents for this subject (14)

Document information

Uploaded on
April 20, 2025
Number of pages
46
Written in
2024/2025
Type
Summary

Subjects

  • bloedhersenbarriere
  • bhb
  • lipinski
  • lipinski rule of 5
  • log p
  • tpsa
  • log d
  • passief transport
  • tight junctiom

Content preview

Image credits: Roche
Bloed Hersen Barrière Passage
Ed Moret




UIPS Utrecht Institute for
Pharmaceutical Sciences
1

,Uitgangspunt bij Bloed Hersen Barriere
Bouwstenen en voeding zijn nodig in de hersenen
Neurotransmitters komen niet uit voeding in de hersenen
Geneesmiddelen zijn lichaamsvreemd en mogen niet in de hersenen komen




Chen and Liu, Adv
Drug Del Rev 64
(2012) 640




UIPS Utrecht Institute for
Pharmaceutical Sciences

,Maar welke moleculen komen in de hersenen? Liu, Drug Disc Today 2
Meet in vivo
Meet in vitro
Meet fys/chem eigenschappen
Bereken fys/chem eigenschappen
Bereken eenvoudige voorspellers
Combineer alle kennis


Indien niet: transporters?




UIPS Utrecht Institute for
Pharmaceutical Sciences

, Literatuur:
Recent. Goed tijdschrift.




UIPS Utrecht Institute for
Pharmaceutical Sciences
$8.65
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