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Exam (elaborations)

ACAAI BOARD REVIEW 5TH EDITION CHAPTER I IMMUNE SYSTEM AND RESEARCH PRINCIPLES WITH COMPLETE ANSWERS

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ACAAI Board Review 5th Edition Chapter I Immune System and Research Principles

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ACAAI











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Uploaded on
April 18, 2025
Number of pages
115
Written in
2024/2025
Type
Exam (elaborations)
Contains
Questions & answers

Subjects

  • acaai

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1 of 184

Definition



Large azurophilic granules in neutrophils, eosinophils and other
granulocytes



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What type of granules are
What are the mechanisms of central B
enlarged in Chediak- Higashi
cell tolerance?

, Syndrome


What are the mechanisms of central T What clinical criteria defines
cell tolerance? neutrophil engraftment?


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2 of 184

Definition



Transferred across placenta and fetus gut lumen via the IgG-specific Fc
receptor - neonatal Fc receptor (FcRn)



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What is the function of thymic stromal What are the major effector functions
Lymphoprotein (TSLP)? of IFN-γ?




What is the result of IFNγ receptor How is IgG transferred from
deficiency? mother to fetus?


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3 of 184

Definition

,L-selectin is found on leukocytes (E-selectin and P-selectin are found
on endothelium; P-selectin is also found on platelets)

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What medications are used for Where does negative selection occur
myeloablative for conditioning? for T cells?




Which selectin is not found on MHC class II molecule presents
endothelium? which type of antigen?


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4 of 184

Definition



Th1 cell differentiation (via T-bet), inhibits class switching to IgE and
IgG4, stimulates expression of MHCs on APCs, activates macrophages
to kill phagocytosed microbes



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Where does negative selection occur
What is the hapten-carrier effect?
for T cells?




What are the major effector What is the epithelial surface
functions of IFN-γ? receptor for rhinoviruses?

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5 of 184

Term



What is prevalence?



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The total number of deaths in a A measure of disease present
population as one point in time




The rate at which new cases of a The average duration of a disease in a
disease occur population


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6 of 184

Definition



Fagan nomogram



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