,
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Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
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Multiple Choice
hu
Identify the choice that best completes the statement or answers the question.
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1. Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?
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a. Pentose phosphate shunt c. Glycolysis hu hu
b. Luebering-Rapoport shunt d. Methemoglobin reductase hu h u hu
2. A unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s IV failed. The
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unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most accurate?
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a. The unit of blood should be discarded immediately.
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b. The unit of blood can be returned to inventory. hu hu hu hu hu hu hu hu
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
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d. The unit of blood must be transfused with 24 hours.
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3. What is the average diameter of a platelet?
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a. 5 to 10 µm hu hu hu c. 1 to 2 µm hu hu hu
b. 2 to 4 µm hu hu hu d. 4 to 6 µm
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4. In the normal hemoglobin-
hu hu hu
oxygen dissociation curve, what percentage of oxygen is released to the tissues when PO2 averages 40
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mm Hg? hu
a. 75% c. 100%
b. 25% d. 50% h u
5. What factors are known to influence platelet metabolism and function?
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a. Storage temperature c. Platelet count hu hu
b. Initial pH d. All of the above
hu h u hu hu hu
6. Which of the following red blood cell morphologies may be present on the peripheral blood smear as a result
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of loss of RBC membrane?
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a. Spherocytes c. Burr cells hu
b. Target cells d. Schistocytes hu h u
7. What does the term autologous transfusion refer to?
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a. A parent donating blood for his or her child
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b. An individual donating blood for a friend
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c. An individual donating blood for a relative hu hu hu hu hu hu
d. An individual donating blood for his or her own transfusion
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8. What is the primary function of hemoglobin?
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a. Iron metabolism hu c. Oxygen transport hu
b. Porphyrin synthesis hu d. Signal transduction
h u hu
9. All of the following areas of red blood cell biology are crucial for normal erythrocyte survival except:
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a. Cellular metabolism. c. Site of the ABO antigen attachment.
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b. RBC membrane. d. Hemoglobin structure.
hu h u hu
a
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h u 10. What is the correct biochemical composition of the RBC membrane?
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a. 52% protein, 40% lipid, 8% carbohydrate hu hu hu hu hu
b. 40% protein, 8% lipid, 52% carbohydrate hu hu hu hu hu
c. 8% protein, 52% lipid, 40% carbohydrate
hu hu hu hu hu
d. 8% lipid, 40% carbohydrate, 52% protein
hu hu hu hu hu
h u 11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
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except:
a. Decreased pH. c. Increased ATP level. hu hu hu
b. Loss of red blood cell function. hud. Decreased glucose consumption.
hu hu hu hu h u hu hu
h u 12. Which red blood cell preservative has a storage time of 35 days?
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a. ACD c. AS-1
b. CPDA-1 d. CPD h u h u
h u 13. The RBC membrane is relatively permeable to all of the following except:
h u hu hu hu hu hu hu hu hu hu hu hu
a. Chloride. c. Bicarbonate.
b. Sodium. d. Water. h u
h u 14. What percentage of platelets is sequestered in the spleen as functional reserve after being released from th
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
e bone marrow?
hu hu
a. 30% c. 10%
b. 50% d. 25% h u h u
h u 15. What is the major biochemical consideration in platelet storage?
h u hu hu hu hu hu hu hu hu
a. Glucose metabolism c. Production of carbon dioxide
hu hu hu hu
b. Oxygen supply d. Regulation of pH
hu h u hu hu
h u 16. What would the hemoglobin-
hu hu hu hu
oxygen dissociation curve depict in a patient exhibiting clinical signs of alkalosis?
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a. Normal c. Shift to the right hu hu hu
b. Shift to the left hu d. None of the above
hu hu h u hu hu hu
h u 17. Name the main lipid components of a red blood cell membrane.
h u hu hu hu hu hu hu hu hu hu hu
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A h u hu
h u 18. The ABO blood groups were discovered in 1901 by whom?
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a. Charles Drew c. Loutit and Mollison
hu hu hu
b. Karl Landsteiner hud. Edward Lindeman h u hu
h u 19. A standing order of platelets was shipped to your facility by your supplier. It was inadvertently left in the c
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
orner of the department until discovered 36 hours later. What would the appropriate action be for the blood
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
banker?
a. If the temperature in the box was 22 +/-
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2°C and the platelet swirl seemed OK, it would be OK to accept the unit into inventory.
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
b. The platelets have fallen outside the supplier’s quality assurance. The unit should be di
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scarded because the pH has probably dropped too low and platelet activation has been c
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ompromised.
c. If the temperature was 1°C to 6°C and the platelet swirl seemed OK, it would be OK to
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
a
,https://www.stuvia.com/
Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
hu hu hu hu hu hu hu hu hu hu
Multiple Choice
hu
Identify the choice that best completes the statement or answers the question.
hu hu hu hu hu hu hu hu hu hu hu
1. Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?
hu hu hu hu hu hu hu hu hu hu hu hu hu
a. Pentose phosphate shunt c. Glycolysis hu hu
b. Luebering-Rapoport shunt d. Methemoglobin reductase hu h u hu
2. A unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s IV failed. The
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most accurate?
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
a. The unit of blood should be discarded immediately.
hu hu hu hu hu hu hu
b. The unit of blood can be returned to inventory. hu hu hu hu hu hu hu hu
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
d. The unit of blood must be transfused with 24 hours.
hu hu hu hu hu hu hu hu hu
3. What is the average diameter of a platelet?
hu hu hu hu hu hu hu
a. 5 to 10 µm hu hu hu c. 1 to 2 µm hu hu hu
b. 2 to 4 µm hu hu hu d. 4 to 6 µm
h u h u hu hu hu
4. In the normal hemoglobin-
hu hu hu
oxygen dissociation curve, what percentage of oxygen is released to the tissues when PO2 averages 40
hu hu hu hu hu hu hu hu hu hu hu hu hu h u hu hu
mm Hg? hu
a. 75% c. 100%
b. 25% d. 50% h u
5. What factors are known to influence platelet metabolism and function?
hu hu hu hu hu hu hu hu hu
a. Storage temperature c. Platelet count hu hu
b. Initial pH d. All of the above
hu h u hu hu hu
6. Which of the following red blood cell morphologies may be present on the peripheral blood smear as a result
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
of loss of RBC membrane?
hu hu hu hu hu
a. Spherocytes c. Burr cells hu
b. Target cells d. Schistocytes hu h u
7. What does the term autologous transfusion refer to?
hu hu hu hu hu hu hu
a. A parent donating blood for his or her child
hu hu hu hu hu hu hu hu
b. An individual donating blood for a friend
hu hu hu hu hu hu
c. An individual donating blood for a relative hu hu hu hu hu hu
d. An individual donating blood for his or her own transfusion
hu hu hu hu hu hu hu hu hu
8. What is the primary function of hemoglobin?
hu hu hu hu hu hu
a. Iron metabolism hu c. Oxygen transport hu
b. Porphyrin synthesis hu d. Signal transduction
h u hu
9. All of the following areas of red blood cell biology are crucial for normal erythrocyte survival except:
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
a. Cellular metabolism. c. Site of the ABO antigen attachment.
hu hu hu hu hu hu
b. RBC membrane. d. Hemoglobin structure.
hu h u hu
a
,https://www.stuvia.com/
h u 10. What is the correct biochemical composition of the RBC membrane?
h u hu hu hu hu hu hu hu hu hu
a. 52% protein, 40% lipid, 8% carbohydrate hu hu hu hu hu
b. 40% protein, 8% lipid, 52% carbohydrate hu hu hu hu hu
c. 8% protein, 52% lipid, 40% carbohydrate
hu hu hu hu hu
d. 8% lipid, 40% carbohydrate, 52% protein
hu hu hu hu hu
h u 11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
h u hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
except:
a. Decreased pH. c. Increased ATP level. hu hu hu
b. Loss of red blood cell function. hud. Decreased glucose consumption.
hu hu hu hu h u hu hu
h u 12. Which red blood cell preservative has a storage time of 35 days?
h u hu hu hu hu hu hu hu hu hu hu hu
a. ACD c. AS-1
b. CPDA-1 d. CPD h u h u
h u 13. The RBC membrane is relatively permeable to all of the following except:
h u hu hu hu hu hu hu hu hu hu hu hu
a. Chloride. c. Bicarbonate.
b. Sodium. d. Water. h u
h u 14. What percentage of platelets is sequestered in the spleen as functional reserve after being released from th
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
e bone marrow?
hu hu
a. 30% c. 10%
b. 50% d. 25% h u h u
h u 15. What is the major biochemical consideration in platelet storage?
h u hu hu hu hu hu hu hu hu
a. Glucose metabolism c. Production of carbon dioxide
hu hu hu hu
b. Oxygen supply d. Regulation of pH
hu h u hu hu
h u 16. What would the hemoglobin-
hu hu hu hu
oxygen dissociation curve depict in a patient exhibiting clinical signs of alkalosis?
hu hu hu hu hu hu hu hu hu hu hu
a. Normal c. Shift to the right hu hu hu
b. Shift to the left hu d. None of the above
hu hu h u hu hu hu
h u 17. Name the main lipid components of a red blood cell membrane.
h u hu hu hu hu hu hu hu hu hu hu
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A h u hu
h u 18. The ABO blood groups were discovered in 1901 by whom?
h u hu hu hu hu hu hu hu hu hu
a. Charles Drew c. Loutit and Mollison
hu hu hu
b. Karl Landsteiner hud. Edward Lindeman h u hu
h u 19. A standing order of platelets was shipped to your facility by your supplier. It was inadvertently left in the c
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
orner of the department until discovered 36 hours later. What would the appropriate action be for the blood
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
banker?
a. If the temperature in the box was 22 +/-
hu hu hu hu hu hu hu hu
2°C and the platelet swirl seemed OK, it would be OK to accept the unit into inventory.
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
b. The platelets have fallen outside the supplier’s quality assurance. The unit should be di
hu hu hu hu hu hu hu hu hu hu hu hu hu
scarded because the pH has probably dropped too low and platelet activation has been c
hu hu hu hu hu hu hu hu hu hu hu hu hu hu
ompromised.
c. If the temperature was 1°C to 6°C and the platelet swirl seemed OK, it would be OK to
hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu hu
a
