TEST BANK
, Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 4th
edition Woo Robinson Test Bank
Chapter 1. The Role of the Nurse Practitioner as PrescriberMultiple Choice
Identify the choice that best completes the statement or answers the question.
1. Nurse practitioner prescriptive authority is regulated by:
1. The National Council of State Boards of Nursing
2. The U.S. Drug Enforcement Administration
3. The State Board of Nursing for each state
4. The State Board of Pharmacy
2. The benefits to the patient of having an Advanced Practice Registered Nurse (APRN) prescriber
include:
1. Nurses know more about Pharmacology than other prescribers because they take it
both in their basic nursing program and in their APRN program.
2. Nurses care for the patient from a holistic approach and include the patient in
decision making regarding their care.
3. APRNs are less likely to prescribe narcotics and other controlled substances.
4. APRNs are able to prescribe independently in all states, whereas a physician’s
assistant needs to have a physician supervising their practice.
3. Clinical judgment in prescribing includes:
1. Factoring in the cost to the patient of the medication prescribed
2. Always prescribing the newest medication available for the disease process
3. Handing out drug samples to poor patients
4. Prescribing all generic medications to cut costs
4. Criteria for choosing an effective drug for a disorder include:
1. Asking the patient what drug they think would work best for them
2. Consulting nationally recognized guidelines for disease management
3. Prescribing medications that are available as samples before writing a prescription
4. Following U.S. Drug Enforcement Administration guidelines for prescribing
5. Nurse practitioner practice may thrive under health-care reform because of:
1. The demonstrated ability of nurse practitioners to control costs and improve patient
outcomes
2. The fact that nurse practitioners will be able to practice independently
3. The fact that nurse practitioners will have full reimbursement under health-
care reform
4. The ability to shift accountability for Medicaid to the state level
, Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 4th
edition Woo Robinson Test Bank
Chapter 1. The Role of the Nurse Practitioner as Prescriber
Answer Section
MULTIPLE CHOICE
1. ANS: 3 PTS: 1
2. ANS: 2 PTS: 1
3. ANS: 1 PTS: 1
4. ANS: 2 PTS: 1
5. ANS: 1 PTS: 1
, Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 4th
edition Woo Robinson Test Bank
Chapter 2. Review of the Basic Principles of Pharmacology
Multiple Choice
Identify the choice that best completes the statement or answers the question.
1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to
prescribing because:
1. Distribution of drugs to target tissue may be affected.
2. The solubility of the drug will not match the site of absorption.
3. There will be less free drug available to generate an effect.
4. Drugs bound to albumin are readily excreted by the kidneys.
2. Drugs that have a significant first-pass effect:
1. Must be given by the enteral (oral) route only
2. Bypass the hepatic circulation
3. Are rapidly metabolized by the liver and may have little if any desired action
4. Are converted by the liver to more active and fat-soluble forms
3. The route of excretion of a volatile drug will likely be the:
1. Kidneys
2. Lungs
3. Bile and feces
4. Skin
4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage
reservoir of the drug. Storage reservoirs:
1. Assure that the drug will reach its intended target tissue
2. Are the reason for giving loading doses
3. Increase the length of time a drug is available and active
4. Are most common in collagen tissues
5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
1. Propensity to go to the target receptor
2. Biological half-life
3. Pharmacodynamics
4. Safety and side effects
6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the
prescription. This is considered a loading dose. A loading dose:
1. Rapidly achieves drug levels in the therapeutic range
2. Requires four- to five-half-lives to attain
3. Is influenced by renal function
4. Is directly related to the drug circulating to the target tissues
7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect
is the:
1. Minimum adverse effect level
2. Peak of action
,Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 4th
edition Woo Robinson Test Bank
3. Onset of action
4. Therapeutic range
8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
1. When the drug has a wide therapeutic range
2. When the drug will be administered for a short time only
3. When there is a high correlation between the dose and saturation of receptor sites
4. To determine if a drug is in the therapeutic range
9. A laboratory result indicates that the peak level for a drug is above the minimum toxic concentration.
This means that the:
1. Concentration will produce therapeutic effects
2. Concentration will produce an adverse response
3. Time between doses must be shortened
4. Duration of action of the drug is too long
10. Drugs that are receptor agonists may demonstrate what property?
1. Irreversible binding to the drug receptor site
2. Upregulation with chronic use
3. Desensitization or downregulation with continuous use
4. Inverse relationship between drug concentration and drug action
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
1. Downregulation of the drug receptor
2. An exaggerated response if abruptly discontinued
3. Partial blockade of the effects of agonist drugs
4. An exaggerated response to competitive drug agonists
12. Factors that affect gastric drug absorption include:
1. Liver enzyme activity
2. Protein-binding properties of the drug molecule
3. Lipid solubility of the drug
4. Ability to chew and swallow
13. Drugs administered via IV:
1. Need to be lipid soluble in order to be easily absorbed
2. Begin distribution into the body immediately
3. Are easily absorbed if they are nonionized
4. May use pinocytosis to be absorbed
14. When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is:
1. The sum of the effects of each drug individually
2. Greater than the sum of the effects of each drug individually
3. Less than the effect of each drug individually
4. Not predictable, as it varies with each individual
15. Which of the following statements about bioavailability is true?
1. Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained-release mechanisms.
2. All brands of a drug have the same bioavailability.
,Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 4th
edition Woo Robinson Test Bank
3. Drugs fthat fare fadministered fmore fthan fonce fa fday fhave fgreater fbioavailability fthan
, Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 4th
edition Woo Robinson Test Bank
drugs fgiven fonce fdaily.
4. Combining fan factive fdrug fwith fan finert fsubstance fdoes fnot faffect fbioavailability.
16. fWhich fof fthe ffollowing fstatements fabout fthe fmajor fdistribution fbarriers f(blood-
brain for ffetal-placental) fis ftrue?
1. Water fsoluble fand fionized fdrugs fcross fthese fbarriers frapidly.
2. The fblood-brain fbarrier fslows fthe fentry fof fmany fdrugs finto fand ffrom fbrain fcells.
3. The ffetal-placental fbarrier fprotects fthe ffetus ffrom fdrugs ftaken fby fthe fmother.
4. Lipid-soluble fdrugs fdo fnot fpass fthese fbarriers fand fare fsafe ffor fpregnant fwomen.
17. fDrugs fare fmetabolized fmainly fby fthe fliver fvia fphase fI for fphase fII freactions. fThe fpurpose
fof fboth fof fthese ftypes fof freactions f is fto:
1. Inactivate fprodrugs fbefore fthey fcan fbe factivated fby ftarget ftissues
2. Change fthe fdrugs fso fthey fcan fcross fplasma fmembranes
3. Change fdrug fmolecules fto fa fform fthat fan fexcretory forgan fcan fexcrete
4. Make fthese fdrugs fmore fionized fand fpolar fto ffacilitate fexcretion
18. fOnce fthey fhave fbeen f metabolized fby fthe fliver, fthe fmetabolites fmay fbe:
1. More factive fthan fthe fparent fdrug
2. Less factive fthan fthe fparent fdrug
3. Totally f“deactivated” fso fthey fare fexcreted fwithout fany feffect
4. All fof fthe fabove
19. fAll fdrugs fcontinue fto fact fin fthe fbody funtil fthey fare fchanged for fexcreted. fThe fability fof
fthe fbody fto fexcrete fdrugs fvia fthe frenal fsystem fwould f be f increased f by:
1. Reduced fcirculation fand fperfusion fof fthe fkidney
2. Chronic frenal fdisease
3. Competition ffor fa ftransport fsite fby fanother fdrug
4. Unbinding fa fnonvolatile fdrug ffrom fplasma fproteins
20. fSteady fstate f is:
1. The fpoint fon fthe fdrug fconcentration fcurve fwhen fabsorption fexceeds fexcretion
2. When fthe famount fof fdrug fin fthe fbody fremains fconstant
3. When fthe famount fof fdrug fin fthe fbody fstays fbelow fthe fminimum
ftoxic fconcentration
4. All fof fthe fabove
21. fTwo fdifferent fpain f medications fare fgiven ftogether ffor fpain frelief. fThe fdrug—drug finteraction fis:
1. Synergistic
2. Antagonistic
3. Potentiative
4. Additive
22. fActions ftaken fto freduce fdrug—drug finteraction fproblems finclude fall fof fthe ffollowing fEXCEPT:
1. Reducing fthe fdosage fof fone fof fthe fdrugs
2. Scheduling ftheir fadministration fat fdifferent ftimes
3. Prescribing fa fthird fdrug fto fcounteract fthe fadverse freaction fof fthe fcombination
4. Reducing fthe fdosage fof fboth fdrugs
, Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 4th
edition Woo Robinson Test Bank
Chapter 1. The Role of the Nurse Practitioner as PrescriberMultiple Choice
Identify the choice that best completes the statement or answers the question.
1. Nurse practitioner prescriptive authority is regulated by:
1. The National Council of State Boards of Nursing
2. The U.S. Drug Enforcement Administration
3. The State Board of Nursing for each state
4. The State Board of Pharmacy
2. The benefits to the patient of having an Advanced Practice Registered Nurse (APRN) prescriber
include:
1. Nurses know more about Pharmacology than other prescribers because they take it
both in their basic nursing program and in their APRN program.
2. Nurses care for the patient from a holistic approach and include the patient in
decision making regarding their care.
3. APRNs are less likely to prescribe narcotics and other controlled substances.
4. APRNs are able to prescribe independently in all states, whereas a physician’s
assistant needs to have a physician supervising their practice.
3. Clinical judgment in prescribing includes:
1. Factoring in the cost to the patient of the medication prescribed
2. Always prescribing the newest medication available for the disease process
3. Handing out drug samples to poor patients
4. Prescribing all generic medications to cut costs
4. Criteria for choosing an effective drug for a disorder include:
1. Asking the patient what drug they think would work best for them
2. Consulting nationally recognized guidelines for disease management
3. Prescribing medications that are available as samples before writing a prescription
4. Following U.S. Drug Enforcement Administration guidelines for prescribing
5. Nurse practitioner practice may thrive under health-care reform because of:
1. The demonstrated ability of nurse practitioners to control costs and improve patient
outcomes
2. The fact that nurse practitioners will be able to practice independently
3. The fact that nurse practitioners will have full reimbursement under health-
care reform
4. The ability to shift accountability for Medicaid to the state level
, Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 4th
edition Woo Robinson Test Bank
Chapter 1. The Role of the Nurse Practitioner as Prescriber
Answer Section
MULTIPLE CHOICE
1. ANS: 3 PTS: 1
2. ANS: 2 PTS: 1
3. ANS: 1 PTS: 1
4. ANS: 2 PTS: 1
5. ANS: 1 PTS: 1
, Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 4th
edition Woo Robinson Test Bank
Chapter 2. Review of the Basic Principles of Pharmacology
Multiple Choice
Identify the choice that best completes the statement or answers the question.
1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to
prescribing because:
1. Distribution of drugs to target tissue may be affected.
2. The solubility of the drug will not match the site of absorption.
3. There will be less free drug available to generate an effect.
4. Drugs bound to albumin are readily excreted by the kidneys.
2. Drugs that have a significant first-pass effect:
1. Must be given by the enteral (oral) route only
2. Bypass the hepatic circulation
3. Are rapidly metabolized by the liver and may have little if any desired action
4. Are converted by the liver to more active and fat-soluble forms
3. The route of excretion of a volatile drug will likely be the:
1. Kidneys
2. Lungs
3. Bile and feces
4. Skin
4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage
reservoir of the drug. Storage reservoirs:
1. Assure that the drug will reach its intended target tissue
2. Are the reason for giving loading doses
3. Increase the length of time a drug is available and active
4. Are most common in collagen tissues
5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
1. Propensity to go to the target receptor
2. Biological half-life
3. Pharmacodynamics
4. Safety and side effects
6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the
prescription. This is considered a loading dose. A loading dose:
1. Rapidly achieves drug levels in the therapeutic range
2. Requires four- to five-half-lives to attain
3. Is influenced by renal function
4. Is directly related to the drug circulating to the target tissues
7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect
is the:
1. Minimum adverse effect level
2. Peak of action
,Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 4th
edition Woo Robinson Test Bank
3. Onset of action
4. Therapeutic range
8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
1. When the drug has a wide therapeutic range
2. When the drug will be administered for a short time only
3. When there is a high correlation between the dose and saturation of receptor sites
4. To determine if a drug is in the therapeutic range
9. A laboratory result indicates that the peak level for a drug is above the minimum toxic concentration.
This means that the:
1. Concentration will produce therapeutic effects
2. Concentration will produce an adverse response
3. Time between doses must be shortened
4. Duration of action of the drug is too long
10. Drugs that are receptor agonists may demonstrate what property?
1. Irreversible binding to the drug receptor site
2. Upregulation with chronic use
3. Desensitization or downregulation with continuous use
4. Inverse relationship between drug concentration and drug action
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
1. Downregulation of the drug receptor
2. An exaggerated response if abruptly discontinued
3. Partial blockade of the effects of agonist drugs
4. An exaggerated response to competitive drug agonists
12. Factors that affect gastric drug absorption include:
1. Liver enzyme activity
2. Protein-binding properties of the drug molecule
3. Lipid solubility of the drug
4. Ability to chew and swallow
13. Drugs administered via IV:
1. Need to be lipid soluble in order to be easily absorbed
2. Begin distribution into the body immediately
3. Are easily absorbed if they are nonionized
4. May use pinocytosis to be absorbed
14. When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is:
1. The sum of the effects of each drug individually
2. Greater than the sum of the effects of each drug individually
3. Less than the effect of each drug individually
4. Not predictable, as it varies with each individual
15. Which of the following statements about bioavailability is true?
1. Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained-release mechanisms.
2. All brands of a drug have the same bioavailability.
,Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 4th
edition Woo Robinson Test Bank
3. Drugs fthat fare fadministered fmore fthan fonce fa fday fhave fgreater fbioavailability fthan
, Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 4th
edition Woo Robinson Test Bank
drugs fgiven fonce fdaily.
4. Combining fan factive fdrug fwith fan finert fsubstance fdoes fnot faffect fbioavailability.
16. fWhich fof fthe ffollowing fstatements fabout fthe fmajor fdistribution fbarriers f(blood-
brain for ffetal-placental) fis ftrue?
1. Water fsoluble fand fionized fdrugs fcross fthese fbarriers frapidly.
2. The fblood-brain fbarrier fslows fthe fentry fof fmany fdrugs finto fand ffrom fbrain fcells.
3. The ffetal-placental fbarrier fprotects fthe ffetus ffrom fdrugs ftaken fby fthe fmother.
4. Lipid-soluble fdrugs fdo fnot fpass fthese fbarriers fand fare fsafe ffor fpregnant fwomen.
17. fDrugs fare fmetabolized fmainly fby fthe fliver fvia fphase fI for fphase fII freactions. fThe fpurpose
fof fboth fof fthese ftypes fof freactions f is fto:
1. Inactivate fprodrugs fbefore fthey fcan fbe factivated fby ftarget ftissues
2. Change fthe fdrugs fso fthey fcan fcross fplasma fmembranes
3. Change fdrug fmolecules fto fa fform fthat fan fexcretory forgan fcan fexcrete
4. Make fthese fdrugs fmore fionized fand fpolar fto ffacilitate fexcretion
18. fOnce fthey fhave fbeen f metabolized fby fthe fliver, fthe fmetabolites fmay fbe:
1. More factive fthan fthe fparent fdrug
2. Less factive fthan fthe fparent fdrug
3. Totally f“deactivated” fso fthey fare fexcreted fwithout fany feffect
4. All fof fthe fabove
19. fAll fdrugs fcontinue fto fact fin fthe fbody funtil fthey fare fchanged for fexcreted. fThe fability fof
fthe fbody fto fexcrete fdrugs fvia fthe frenal fsystem fwould f be f increased f by:
1. Reduced fcirculation fand fperfusion fof fthe fkidney
2. Chronic frenal fdisease
3. Competition ffor fa ftransport fsite fby fanother fdrug
4. Unbinding fa fnonvolatile fdrug ffrom fplasma fproteins
20. fSteady fstate f is:
1. The fpoint fon fthe fdrug fconcentration fcurve fwhen fabsorption fexceeds fexcretion
2. When fthe famount fof fdrug fin fthe fbody fremains fconstant
3. When fthe famount fof fdrug fin fthe fbody fstays fbelow fthe fminimum
ftoxic fconcentration
4. All fof fthe fabove
21. fTwo fdifferent fpain f medications fare fgiven ftogether ffor fpain frelief. fThe fdrug—drug finteraction fis:
1. Synergistic
2. Antagonistic
3. Potentiative
4. Additive
22. fActions ftaken fto freduce fdrug—drug finteraction fproblems finclude fall fof fthe ffollowing fEXCEPT:
1. Reducing fthe fdosage fof fone fof fthe fdrugs
2. Scheduling ftheir fadministration fat fdifferent ftimes
3. Prescribing fa fthird fdrug fto fcounteract fthe fadverse freaction fof fthe fcombination
4. Reducing fthe fdosage fof fboth fdrugs
