CPPS 325 FINAL EXAM QUESTIONS WITH CORRECT ANSWERS 2025

CPPS 325 FINAL EXAM QUESTIONS WITH
CORRECT ANSWERS 2025
WhatVareVtheV5Vwell-knownVenzyme-linkedVcellVsurfaceVreceptors?V-VCORRECTVANSWERV-
1.VReceptorVGuanylylVCyclase:VproducesVcGMP
2.VRTK:VphosphorylateVtyrosineVresiduesVleadingVtoVassociationVofVsignallingVmoleculesVandVcascade
3.VTKVAssociatedVReceptors:VassociateVwithVproteinsVhavingVTKVactivityV
4.VReceptorVTyrosineVPhosphates:VRemovesVphosphateVonVtyrosineVresiduesV
5.VReceptorVSerine/ThreonineVKinases:VphosphorylateVspecificVSerine/ThreonineVresiduesVonVICVsignallin
gVmolecules

HowVareVRTKVandVTKVAssociatedVReceptorsVdifferent?V-VCORRECTVANSWERV-
RTKVphosphorylateVtyrosineVwhileVassociatedVreceptorsVbind/findVproteinsVwithVTKVactivityVtoVinitiateVth
eVcascadeVofVsignalling.

WhatVisVtheVreciprocalVofVRTK?V-VCORRECTVANSWERV-
ReceptorVTyrosineVPhosphatases.VTheyVtakeVtheVphosphateVoffVtheVtyrosineVresiduesVtoVinactivateVsignalli
ngVcascades.V
Ex.VTransformingVGFVBetaVsuperfamilyVofVreceptors,VcellVtypeVdependent.

WhatVisVtheVmajorVmechanismVforVreceptorVsignalVtransduction?V-VCORRECTVANSWERV-
TyrosineVkinaseVphosphorylation

RTKVvs.VSerine/ThreonineVPhosphorylationV?V-VCORRECTVANSWERV-
TyrosineVphosphorylationVisVrareV(1%)VrelativeVtoVserine/threonineVresidueVphosphorylation.VTyrosineVph
osphorylationVisVtheVmajorVmechanismVofVreceptorVsignalVtransduction.

WhatVisVtheVnetVeffectVofVactivatedVTKs?V-VCORRECTVANSWERV-
TyrosineVphosphorylationVonVtargetVproteins.

WhatVdoVTKVpathwaysVmediate?V-VCORRECTVANSWERV-
CellVgrowthV(growthVfactors),Vdifferentiation,VhostVdefense,VmetabolicVregulation,VcellVsurvivalVpathwaysV
(survivalVfactors).

WhatVareVamplifiersVofVtheVTKVpathways?V-VCORRECTVANSWERV-PI3-KV->VPIP3V
PLCV->VDAGVandVInsP3&Ca2+

WhatVareVRTKVmediatedVactionsVinVtheVcell?V-VCORRECTVANSWERV-
regulationVofVcellVproliferation,Vdifferentiation,VandVcellVmotility,VpromotionVofVcellVsurvivalVandVmodulat
ionVofVcellularVmetabolism.

TKsVexistVinVeitherVtheVcytosolVorVasVtransmembraneVreceptors,VwhatVareVtheVdifferencesVinVtheVtwoVtypes
?V-VCORRECTVANSWERV-CytosolVreceptorsVhaveVanVsrcVN-
terminalVregion.VCytosolVhasVnoVmembraneVspanningVdomain.

TMVreceptorVhasVaVsingleVmembraneVspanningVhydrophobicVTMVdomain.VEx)VEpidermalVGFVRTK.

WhatVisVsrc?V-VCORRECTVANSWERV-SrcVisVaVnon-

, receptorVTK,VsoVitVdoesVnotVspanVaVmembrane.VItVisVaVtyrosineVkinase.VAndValthoughVitVisVcytoplasmicVT
KVitVcanVstillVbindVtoVactivatedVRTKs.

WhatVisVcontactVinhibitionVconfluency?V-VCORRECTVANSWERV-
StopsVSrcVdomainsVsignallingVandVthereforeVcellsVstopVdividing.V

IfVthereVisVanVissueVthenVcancerVcanVresultVandVmutationVcausesVanVinhibitionVofVtheVstopVsignalVsoVtheVce
llsVkeepVgrowingVandVdividing.

WhatVareVSHVdomains?V-VCORRECTVANSWERV-
SrcVhomologyVdomains.VSrcVandVotherVproteinsVthatVhaveVsrc-
homologyVdomainsVcanVbingVtoVactivatedVRTKs.

WhatVareVtheVdifferentVSHVdomainsVinVproteins?V-VCORRECTVANSWERV-
ThereVareVSH1,VSH2VandVSH3Vdomains.

WhatVisSH1VdomainVcharacterizedVby?V-VCORRECTVANSWERV-
CatalyticVdomainVofVaVprotein,VforVexampleVtheVreceptor.VandVitVhasVtheVkinaseVactivity.VItVisVresponsibleV
forVphosphorylatingVtyrosineVresidues.

WhatVisVSH2VdomainVcharacterizedVby?V-VCORRECTVANSWERV-
BindsVpeptidesVwithVconsensusV(positionalVinformationVonVC-
terminalVsideVofVtheVphosphorylatedVtyrosine).V
VeryVspecific.V
MediatesVprotein-
proteinVinteractionsVinVcellularVsignallingVcascades.VVeryVcommonVinVproteinsVoutsideVtheVsrcVfamily.

WhatVdoVSH2VandVSH3VdomainsVhaveVasVaVcommonVfunciton?V-VCORRECTVANSWERV-
TheyVmediateVprotein-proteinVinteractionsVinVcellularVsignallingVcascades.V
VeryVcommonVinVproteinsVoutsideVtheVsrcVfamily.

WhatVisVSH3VdomainVcharacterizedVby?V-VCORRECTVANSWERV-InteractsVwithVproline-
richVpeptideVtargetsV(minimalVconsensus).VMediateVprotien-
proteinVinteratctionsVinVtheVcellularVsignallingVcascade.VVeryVcommonVinVproteinsVoutsideVtheVsrcVfamily.

WhatVareVPTBVdomains?V-VCORRECTVANSWERV-(PhosphotyrosineVbindingVdomain)V
BindVtoVphosphorylatedVtyrosine.VFunctionalVequivalentVofVtheVSH2Vdomain,VexceptVforVtheVpositionalVinf
ormational.VIsVnotVtheVC-terminusVlikeVSH2,VbutVtheVN-terminusVsideVofVtheVphosphorylatedVtyrosine.
shcVisVaVPTBVprotein.

WhatVisVtheVnormalVactionVthatVstopsVsignallingVforVcellVdivisionVinVtheVsrcVpathway?V-
VCORRECTVANSWERV-ContactVInhibitionVConfluency




HowVdoVPTBVandVSH2VdomainsVdiffer?V-VCORRECTVANSWERV-
SH2VdomainsVbindsVconsensusVonVtheVC-terminus.
PTBVdomainsVbindsVtheVN-terminus.V
TheyVbothVmediateVcellularVsignalling.

WhatVisVshc?V-VCORRECTVANSWERV-PTBVproteinVthatVdocksVatVtheVN-
terminusVconsensusVdockingVsite.