NU 578 PHARM EXAM QUESTIONS
AND ANSWERS RATED 100%
CORRECT
Signs of agranulocytosis - Answer-Fever and sore throat. Stop methimazole or PTU &
give neupogen to speed up recovery
PTU first line for what? - Answer-First trimester pregnancy
Breast feeding women
During thyroid storm
PTU dose? - Answer-100-300 mg 3 times/day to start. Then switch to maintenance of
50 mg 3 times per day.
Radioactive Iodine - Answer-Hyperthyroidism: destroy thyroid tissue without causing
complete gland destruction
Who can't use radioactive iodine? - Answer-Patients younger than 30 - cancer,
pregnant, breastfeeding
Lugol's Solution - Answer-Decreases iodine uptake by the thyroid, blocks thyroid
hormone production, blocks release of thyroid hormone into blood
What is iodism? - Answer-brassy taste, burning in mouth, sore teeth & gums, frontal HA,
coryza. Fades when you stop iodine.
Signs of Lugol's OD? - Answer-swollen glottis and asyphxia.
Give sodium thiosulfate
Lavage to remove iodine
Lugol's dose for hyperthyroidism? - Answer-2-6 drops 3 times per day for 10 days
Mix with juice to kill bad taste
Combined with PTU as a prep for thyroidectomy
Started 10 days before surgery
Lugol's dose for thyroid storm? - Answer-5-8 drops every 6 hours
Propranolol for Graves' Disease? - Answer-80-120 mg PO every 6 hours
2-4 mg IV every 4 hours
, Pediatric Levothyroxine Dose - Answer-< 3 monts old: 10-15 mcg/kg/d
3-6 months old: 8-10 mcg/kg/d
6-12 months old: 6-8 mcg/kg/d
1-5 years old: 5-6 mcg/kg/d
5-12 years old: 4-5 mcg/kg/d
Average Levothyroxine (T4) dose in adults: - Answer-1.6 mcg/kg/do
< 50: full replacement dose: 100-125 mcg/d
>50: Start at 25-50 mcg/d
>50 with heart disease: start at 12.5-25 mcg/d
Mydexema coma - Answer-Levothyroid 200-500 mcg IV. Can repeat in 24 hours at 100-
300 mcg.
Antiemetic regimen for low risk chemotherapy drugs? - Answer-1 drug: dexamethasone
High chemo drug antiemetic regimen? - Answer-Aprepitant + dexamethasone +
ondasterone or palonosetron. Lorazepam for anticipitory.
Why should pregnant women take unisom & B6? - Answer-Antiemetic of choice.
Why can't a pregnant woman take methylprednisolone for emesis before 10 weeks
gestation? - Answer-Cleft lip.
Drugs that reduce levothyroxine absorption? - Answer-• H2 blockers
• Prevacid
• Malox, Mylanta
• Tums, Os-Cal
• Iron supplements
• Magnesium salts
• Xenical
How should levothyroxine be taken with drugs that delay its absorption? - Answer-Wait
4 hours
How do you adjust levothyroxine if taking drugs that speed up its metabolism? -
Answer-May need to increase levothyroxine dose
Drugs that speed up levothyroxine metabolism? - Answer-• Phenytoin
• Tegretol
• Rifampin
• Zoloft
• Phenobarbitol
What needs to be done if switching brands of levothyroxine? - Answer-Test TSH in 6
weeks.
AND ANSWERS RATED 100%
CORRECT
Signs of agranulocytosis - Answer-Fever and sore throat. Stop methimazole or PTU &
give neupogen to speed up recovery
PTU first line for what? - Answer-First trimester pregnancy
Breast feeding women
During thyroid storm
PTU dose? - Answer-100-300 mg 3 times/day to start. Then switch to maintenance of
50 mg 3 times per day.
Radioactive Iodine - Answer-Hyperthyroidism: destroy thyroid tissue without causing
complete gland destruction
Who can't use radioactive iodine? - Answer-Patients younger than 30 - cancer,
pregnant, breastfeeding
Lugol's Solution - Answer-Decreases iodine uptake by the thyroid, blocks thyroid
hormone production, blocks release of thyroid hormone into blood
What is iodism? - Answer-brassy taste, burning in mouth, sore teeth & gums, frontal HA,
coryza. Fades when you stop iodine.
Signs of Lugol's OD? - Answer-swollen glottis and asyphxia.
Give sodium thiosulfate
Lavage to remove iodine
Lugol's dose for hyperthyroidism? - Answer-2-6 drops 3 times per day for 10 days
Mix with juice to kill bad taste
Combined with PTU as a prep for thyroidectomy
Started 10 days before surgery
Lugol's dose for thyroid storm? - Answer-5-8 drops every 6 hours
Propranolol for Graves' Disease? - Answer-80-120 mg PO every 6 hours
2-4 mg IV every 4 hours
, Pediatric Levothyroxine Dose - Answer-< 3 monts old: 10-15 mcg/kg/d
3-6 months old: 8-10 mcg/kg/d
6-12 months old: 6-8 mcg/kg/d
1-5 years old: 5-6 mcg/kg/d
5-12 years old: 4-5 mcg/kg/d
Average Levothyroxine (T4) dose in adults: - Answer-1.6 mcg/kg/do
< 50: full replacement dose: 100-125 mcg/d
>50: Start at 25-50 mcg/d
>50 with heart disease: start at 12.5-25 mcg/d
Mydexema coma - Answer-Levothyroid 200-500 mcg IV. Can repeat in 24 hours at 100-
300 mcg.
Antiemetic regimen for low risk chemotherapy drugs? - Answer-1 drug: dexamethasone
High chemo drug antiemetic regimen? - Answer-Aprepitant + dexamethasone +
ondasterone or palonosetron. Lorazepam for anticipitory.
Why should pregnant women take unisom & B6? - Answer-Antiemetic of choice.
Why can't a pregnant woman take methylprednisolone for emesis before 10 weeks
gestation? - Answer-Cleft lip.
Drugs that reduce levothyroxine absorption? - Answer-• H2 blockers
• Prevacid
• Malox, Mylanta
• Tums, Os-Cal
• Iron supplements
• Magnesium salts
• Xenical
How should levothyroxine be taken with drugs that delay its absorption? - Answer-Wait
4 hours
How do you adjust levothyroxine if taking drugs that speed up its metabolism? -
Answer-May need to increase levothyroxine dose
Drugs that speed up levothyroxine metabolism? - Answer-• Phenytoin
• Tegretol
• Rifampin
• Zoloft
• Phenobarbitol
What needs to be done if switching brands of levothyroxine? - Answer-Test TSH in 6
weeks.
