Nurs 5315 MSK EXAM 2025 LATEST UPDATED 80+ REAL EXAM
QUESTIONS WITH 100% RATED CORRECT ANSWERS 100%
ACCURATE GET IT CORRECT!!
Which bone cell is primarily responsible for bone resorption?
a. Osteoblast
b. Osteocyte
c. Osteoclast
d. Chondrocyte - (Correct Answer)c. Osteoclast
What signaling molecule secreted by osteocytes inhibits osteoblast activity?
a. RANK
心的坚强决定了我们的命运。当
b. Sclerostin
我们面对挫折时，是一颗不屈的
c. Cathepsin K
心让我们勇敢前行
d. Osteocalcin - (Correct Answer)b. Sclerostin
Which of the following is a biochemical marker of osteoblast activity?
a. Tartrate-resistant acid phosphatase (TRAP)
b. Osteocalcin
c. Cathepsin K
d. Matrix metalloproteinases (MMPs) - (Correct Answer)b. Osteocalcin
What is the primary function of osteocytes within the bone matrix?
a. Synthesizing osteoid
b. Resorbing bone tissue
c. Maintaining bone homeostasis
d. Initiating fracture repair - (Correct Answer)c. Maintaining bone homeostasis
,Which enzyme is secreted by osteoclasts to degrade the collagen matrix?
a. Alkaline phosphatase
b. Cathepsin K
c. Acid phosphatase
d. Osteopontin - (Correct Answer)b. Cathepsin K
True or False: Osteoblasts originate from hematopoietic stem cells. - (Correct Answer)False
(Osteoblasts originate from mesenchymal stem cells.)
True or False: The RANKL/OPG ratio is critical in regulating osteoclast activity. - (Correct
Answer)True
心的坚强决定了我们的命运。当
True or False:Sclerostin production by osteocytes is increased in response to mechanical loading.
我们面对挫折时，是一颗不屈的
- (Correct Answer)False (Sclerostin production decreases in response to mechanical loading.)
心让我们勇敢前行
True or False: Vitamin D deficiency leads to impaired collagen synthesis in the bone matrix. -
(Correct Answer)False (Vitamin D deficiency impairs calcium absorption, while Vitamin C
deficiency affects collagen synthesis.)
True or False: Osteocytes communicate with neighboring cells through dendritic processes in
canaliculi. - (Correct Answer)True
What is the role of the RANK/RANKL/OPG system in bone remodeling?
a. RANK/RANKL interaction promotes osteoblast differentiation and activity, leading to bone
formation.
b. OPG binds to RANKL, preventing its interaction with RANK, thereby inhibiting osteoclast
activity
.c. OPG promotes osteoclast differentiation and increases bone resorption.
, d. RANK/RANKL interaction inhibits osteoblast activity, reducing bone formation. - (Correct
Answer)b. OPG binds to RANKL, preventing its interaction with RANK, thereby inhibiting
osteoclast activity.
What is the primary consequence of excessive osteoclast activity in conditions like osteoporosis?
a. Increased bone formation and density.
b. Reduced bone resorption and stronger bones.
c. Increased bone resorption, reduced bone density, and a higher risk of fractures
.d. Decreased osteoblast activity and delayed fracture healing. - (Correct Answer)c. Increased
bone resorption, reduced bone density, and a higher risk of fractures.
Which of the following are biochemical markers of osteoblast activity?
a. Tartrate-resistant acid phosphatase and cathepsin K.
心的坚强决定了我们的命运。当
b. Alkaline phosphatase and osteocalcin
.c. RANKL and osteoprotegerin. 我们面对挫折时，是一颗不屈的
心让我们勇敢前行
d. Collagen and matrix metalloproteinases. - (Correct Answer)b. Alkaline phosphatase and
osteocalcin.
How do osteocytes contribute to bone health in response to mechanical stress?
a. By producing RANKL to stimulate osteoclast activity.
b. By signaling osteoblasts to increase bone formation and reducing sclerostin production.
c. By increasing sclerostin production to enhance bone resorption.
d. By inhibiting osteoblast activity and reducing bone density. - (Correct Answer)b. By signaling
osteoblasts to increase bone formation and reducing sclerostin production.
How do hormonal changes during menopause affect bone remodeling?
a. Increased estrogen levels stimulate bone resorption
.b. Decreased estrogen levels reduce OPG production, increasing RANKL activity and
osteoclast-mediated bone resorption.
QUESTIONS WITH 100% RATED CORRECT ANSWERS 100%
ACCURATE GET IT CORRECT!!
Which bone cell is primarily responsible for bone resorption?
a. Osteoblast
b. Osteocyte
c. Osteoclast
d. Chondrocyte - (Correct Answer)c. Osteoclast
What signaling molecule secreted by osteocytes inhibits osteoblast activity?
a. RANK
心的坚强决定了我们的命运。当
b. Sclerostin
我们面对挫折时，是一颗不屈的
c. Cathepsin K
心让我们勇敢前行
d. Osteocalcin - (Correct Answer)b. Sclerostin
Which of the following is a biochemical marker of osteoblast activity?
a. Tartrate-resistant acid phosphatase (TRAP)
b. Osteocalcin
c. Cathepsin K
d. Matrix metalloproteinases (MMPs) - (Correct Answer)b. Osteocalcin
What is the primary function of osteocytes within the bone matrix?
a. Synthesizing osteoid
b. Resorbing bone tissue
c. Maintaining bone homeostasis
d. Initiating fracture repair - (Correct Answer)c. Maintaining bone homeostasis
,Which enzyme is secreted by osteoclasts to degrade the collagen matrix?
a. Alkaline phosphatase
b. Cathepsin K
c. Acid phosphatase
d. Osteopontin - (Correct Answer)b. Cathepsin K
True or False: Osteoblasts originate from hematopoietic stem cells. - (Correct Answer)False
(Osteoblasts originate from mesenchymal stem cells.)
True or False: The RANKL/OPG ratio is critical in regulating osteoclast activity. - (Correct
Answer)True
心的坚强决定了我们的命运。当
True or False:Sclerostin production by osteocytes is increased in response to mechanical loading.
我们面对挫折时，是一颗不屈的
- (Correct Answer)False (Sclerostin production decreases in response to mechanical loading.)
心让我们勇敢前行
True or False: Vitamin D deficiency leads to impaired collagen synthesis in the bone matrix. -
(Correct Answer)False (Vitamin D deficiency impairs calcium absorption, while Vitamin C
deficiency affects collagen synthesis.)
True or False: Osteocytes communicate with neighboring cells through dendritic processes in
canaliculi. - (Correct Answer)True
What is the role of the RANK/RANKL/OPG system in bone remodeling?
a. RANK/RANKL interaction promotes osteoblast differentiation and activity, leading to bone
formation.
b. OPG binds to RANKL, preventing its interaction with RANK, thereby inhibiting osteoclast
activity
.c. OPG promotes osteoclast differentiation and increases bone resorption.
, d. RANK/RANKL interaction inhibits osteoblast activity, reducing bone formation. - (Correct
Answer)b. OPG binds to RANKL, preventing its interaction with RANK, thereby inhibiting
osteoclast activity.
What is the primary consequence of excessive osteoclast activity in conditions like osteoporosis?
a. Increased bone formation and density.
b. Reduced bone resorption and stronger bones.
c. Increased bone resorption, reduced bone density, and a higher risk of fractures
.d. Decreased osteoblast activity and delayed fracture healing. - (Correct Answer)c. Increased
bone resorption, reduced bone density, and a higher risk of fractures.
Which of the following are biochemical markers of osteoblast activity?
a. Tartrate-resistant acid phosphatase and cathepsin K.
心的坚强决定了我们的命运。当
b. Alkaline phosphatase and osteocalcin
.c. RANKL and osteoprotegerin. 我们面对挫折时，是一颗不屈的
心让我们勇敢前行
d. Collagen and matrix metalloproteinases. - (Correct Answer)b. Alkaline phosphatase and
osteocalcin.
How do osteocytes contribute to bone health in response to mechanical stress?
a. By producing RANKL to stimulate osteoclast activity.
b. By signaling osteoblasts to increase bone formation and reducing sclerostin production.
c. By increasing sclerostin production to enhance bone resorption.
d. By inhibiting osteoblast activity and reducing bone density. - (Correct Answer)b. By signaling
osteoblasts to increase bone formation and reducing sclerostin production.
How do hormonal changes during menopause affect bone remodeling?
a. Increased estrogen levels stimulate bone resorption
.b. Decreased estrogen levels reduce OPG production, increasing RANKL activity and
osteoclast-mediated bone resorption.
