CLINICAL CHEMISTRY EXAM #4
QUESTIONS WITH COMPLETE
ANSWERS
which route of administration bypasses the first phase of drug processing - Answer-
IV injection
which of the following compounds in prescribed to control patients with manic
depression tendencies - Answer-lithium
carbamazepine primidone and valproic acid are all examples of - Answer-
antiepileptic drugs
which of the following compounds selectively inhibits proliferation and activation of
CD4+ T cells - Answer-cyclosporine A
what is the drug of choice to treat MRSA - Answer-vancomycin
phenobarbital is classified as a - Answer-sedative and hypnotic
which of the following drugs is used as an immunosuppressant in liver transplants -
Answer-tacrolimus
select the four correct pharmacological parameters that determine serum drug
concentration - Answer-absorption, distribution, metabolism, and excretion
which of the following compounds relaxes the smooth muscles of the bronchial
passages - Answer-theophylline
increased serum peak and trough levels of aminoglycosides are often associated
with toxic affects to which of the following organs - Answer-kidney
which of the following compounds is an anticonvulsant used to control tonic-clonic
(grand mal) seizures - Answer-phenytoin
which of the following is an example of an antiarrhythmic drug - Answer-
procainamide
depakene or Depakote are proprietary names for which of the following compounds -
Answer-valproic
a patient with acute intermittent porphyria is deficient in which of the following -
Answer-hydroymethylbilane synthase
the following statement best describes which of the following of the terms listed
below? the pathological condition that develops when iron intake falls below the
,amount required for red blood cell production and iron reserves become depleted -
Answer-anemia
free erythrocyte protoporphyrin levels are useful for assessing exposure to which of
the following metals - Answer-lead
which of the following laboratory test groups and results best reflect a patient with
primary hemochromatosis - Answer-serum iron increased, serum TIBC decrease,
transferrin saturation increased
the addition of sufficient Fe3+ to saturate iron binding sites of transferrin is referred
to as which of the following - Answer-unsaturated iron binding capacity
transferrin circulates as which of the following - Answer-apotransferrin Fe3+
what is the primary storage form of iron - Answer-ferritin
which of the following is the major transport protein of iron - Answer-transferrin
a 25 year old female visits her physician complaining of lethargy and wants to take a
nap all of the time. her physician orders laboratory tests and the results are shown
below. which of the following conditions best represents this patients status serum
iron (ug/dL) decreased TIBC (ug/dL) increased transferrin saturation (%) decreased
serum ferritin (ug/dL) decreased - Answer-iron deficiency anemia
the globin portion of hemoglobin in normal adult humans is composed of which two
amino acids - Answer-two alpha two beta
a 30 year old man with ALA-dehydratase deficient porphyria (ADP) may present with
which of the following clinical features - Answer-abdominal pain and neurological
dysfunction
hemochromatosis is a disease characterized by which of the following - Answer-a
genetically linked disease in which the body accumulates excess amounts of iron
which of the following chromogens will produce a color complex with iron using
spectrophotometry - Answer-ferrozine
how many pyrrole rings are there in a porphyrin structure - Answer-4
what is the unique quality that many porphyrin compounds possess that allows for
their detection within body tissues and in a test tube - Answer-glycine and succinyl
CoA
a 40 year old male patient with hemochromatosis often presents to his clinician with
which of the following triad of symptoms - Answer-bronzing of the skin, cirrhosis, and
diabetes
which of the following porphyrias best reflects this patients symptoms and laboratory
results a 30 year old male presents to his clinician with alcoholic liver disease
,hyperpigmentation blister formation and fragile skin the results of the liver function
tests (AST and ALT) were abnormal the patients urine PBG/ALA was not increased
urine porphyrins analysis reveals and elevation of uroporphyrinogen and
heptacarboxylate - Answer-porphyria cutanea tarda
protoporphyrins that chelate iron are called - Answer-heme
which of the following compounds chelates iron and is the immediate precursor of
heme formation - Answer-protophothyrin IX
In which of the following disorders would the maternal serum level of 1-fetoprotein be
elevated?
A. Neural tube defect.
B. Cardiac ischemia.
C. Down syndrome.
D. Small cell lung carcinoma - Answer-A. Neural tube defect
Which of the following is FALSE about PSA?
A. It is a single-chain glycoprotein
B. It is used as a tumor marker
C. It is not elevated in benign prostatic hyperplasia
D. It is quantified in serum by immunoassays - Answer-C. It is not elevated in benign
prostatic hyperplasia.
Which of the following biomarkers is elevated in nonmucinous epithelial ovarian
cancer?
A. CA 15-3
B. CA 19-9
C. CA 125
D. CEA - Answer-C. CA 125
Which of the following is a sialylated Lewis blood group antigen associated with
colorectal cancer?
A. CA 125
B. CA 15-3
C. PSA
D. CA 19-9 - Answer-D. CA 19-9
Which of the following biomarkers are elevated in advanced stages of breast
cancer?
A. Total and free PSA
B. CEA and alpha-fetoprotein
C. CA 15-3 and CA 549
D. DUPAN-2 and Gastrin - Answer-C. CA 15-3 and CA 549
Which tumor marker is associated with cancer of the urinary bladder?
A. CA 125
B. CA19-9
C. CA 50
D. Nuclear matrix protein - Answer-D. Nuclear matrix protein
, What is the primary clinical usefulness of measuring carcinoembryonic antigen?
A. Diagnosis of lung cancer
B. Diagnosis of colorectal cancer
C. Screening for breast cancer
D. Monitoring for recurrence of colon cancer - Answer-D. Monitoring for recurrence
of colon cancer
levels of 89% carboxyhemoglobin saturation of whole blood are commonly found in
which of the following - Answer-fatal carbon monoxide poisoning
Which of the following techniques is a definitive means for both qualitative and
quantitative analysis of drugs of abuse - Answer-gas chromatography coupled with
mass spectrometry
screening methods for drug abuse testing require which of the following assay
characteristics - Answer-they must be analytically sensitive
urine adulteration test strips are designed to detect which of the following - Answer-
all of the above
which of the following biological fluids is the specimen of choice for screening and/or
analyzing drugs of abuse - Answer-urine
imipramine is classified as - Answer-tricyclic antidepressant
the toxic effect of acetaminophen overdose is - Answer-hepatocystic necrosis
THC is the principal active metabolite of which of the following - Answer-marijuana
valium and Librium are examples of which of the following - Answer-
benzodiazepines
identification of the urinary metabolite bezoylecgonine would be useful indetermining
the presence of which of the following compounds - Answer-cytochrome P450
elevated blood levels of lead will result in a deficiency of which of the following
enzymes - Answer-amino levulinic acid dehydratase
lead exposure causes an increase blood concentration in which of the following
analytes - Answer-zinc-pronto porphyrin
which of the following is a xanthene that potentially could interfere with the
determination of theophylline - Answer-caffeine
following the entrance of a drug into the vascular component it will be carried to all
organs and fluid compartments this statement describes which of the following -
Answer-distribution
QUESTIONS WITH COMPLETE
ANSWERS
which route of administration bypasses the first phase of drug processing - Answer-
IV injection
which of the following compounds in prescribed to control patients with manic
depression tendencies - Answer-lithium
carbamazepine primidone and valproic acid are all examples of - Answer-
antiepileptic drugs
which of the following compounds selectively inhibits proliferation and activation of
CD4+ T cells - Answer-cyclosporine A
what is the drug of choice to treat MRSA - Answer-vancomycin
phenobarbital is classified as a - Answer-sedative and hypnotic
which of the following drugs is used as an immunosuppressant in liver transplants -
Answer-tacrolimus
select the four correct pharmacological parameters that determine serum drug
concentration - Answer-absorption, distribution, metabolism, and excretion
which of the following compounds relaxes the smooth muscles of the bronchial
passages - Answer-theophylline
increased serum peak and trough levels of aminoglycosides are often associated
with toxic affects to which of the following organs - Answer-kidney
which of the following compounds is an anticonvulsant used to control tonic-clonic
(grand mal) seizures - Answer-phenytoin
which of the following is an example of an antiarrhythmic drug - Answer-
procainamide
depakene or Depakote are proprietary names for which of the following compounds -
Answer-valproic
a patient with acute intermittent porphyria is deficient in which of the following -
Answer-hydroymethylbilane synthase
the following statement best describes which of the following of the terms listed
below? the pathological condition that develops when iron intake falls below the
,amount required for red blood cell production and iron reserves become depleted -
Answer-anemia
free erythrocyte protoporphyrin levels are useful for assessing exposure to which of
the following metals - Answer-lead
which of the following laboratory test groups and results best reflect a patient with
primary hemochromatosis - Answer-serum iron increased, serum TIBC decrease,
transferrin saturation increased
the addition of sufficient Fe3+ to saturate iron binding sites of transferrin is referred
to as which of the following - Answer-unsaturated iron binding capacity
transferrin circulates as which of the following - Answer-apotransferrin Fe3+
what is the primary storage form of iron - Answer-ferritin
which of the following is the major transport protein of iron - Answer-transferrin
a 25 year old female visits her physician complaining of lethargy and wants to take a
nap all of the time. her physician orders laboratory tests and the results are shown
below. which of the following conditions best represents this patients status serum
iron (ug/dL) decreased TIBC (ug/dL) increased transferrin saturation (%) decreased
serum ferritin (ug/dL) decreased - Answer-iron deficiency anemia
the globin portion of hemoglobin in normal adult humans is composed of which two
amino acids - Answer-two alpha two beta
a 30 year old man with ALA-dehydratase deficient porphyria (ADP) may present with
which of the following clinical features - Answer-abdominal pain and neurological
dysfunction
hemochromatosis is a disease characterized by which of the following - Answer-a
genetically linked disease in which the body accumulates excess amounts of iron
which of the following chromogens will produce a color complex with iron using
spectrophotometry - Answer-ferrozine
how many pyrrole rings are there in a porphyrin structure - Answer-4
what is the unique quality that many porphyrin compounds possess that allows for
their detection within body tissues and in a test tube - Answer-glycine and succinyl
CoA
a 40 year old male patient with hemochromatosis often presents to his clinician with
which of the following triad of symptoms - Answer-bronzing of the skin, cirrhosis, and
diabetes
which of the following porphyrias best reflects this patients symptoms and laboratory
results a 30 year old male presents to his clinician with alcoholic liver disease
,hyperpigmentation blister formation and fragile skin the results of the liver function
tests (AST and ALT) were abnormal the patients urine PBG/ALA was not increased
urine porphyrins analysis reveals and elevation of uroporphyrinogen and
heptacarboxylate - Answer-porphyria cutanea tarda
protoporphyrins that chelate iron are called - Answer-heme
which of the following compounds chelates iron and is the immediate precursor of
heme formation - Answer-protophothyrin IX
In which of the following disorders would the maternal serum level of 1-fetoprotein be
elevated?
A. Neural tube defect.
B. Cardiac ischemia.
C. Down syndrome.
D. Small cell lung carcinoma - Answer-A. Neural tube defect
Which of the following is FALSE about PSA?
A. It is a single-chain glycoprotein
B. It is used as a tumor marker
C. It is not elevated in benign prostatic hyperplasia
D. It is quantified in serum by immunoassays - Answer-C. It is not elevated in benign
prostatic hyperplasia.
Which of the following biomarkers is elevated in nonmucinous epithelial ovarian
cancer?
A. CA 15-3
B. CA 19-9
C. CA 125
D. CEA - Answer-C. CA 125
Which of the following is a sialylated Lewis blood group antigen associated with
colorectal cancer?
A. CA 125
B. CA 15-3
C. PSA
D. CA 19-9 - Answer-D. CA 19-9
Which of the following biomarkers are elevated in advanced stages of breast
cancer?
A. Total and free PSA
B. CEA and alpha-fetoprotein
C. CA 15-3 and CA 549
D. DUPAN-2 and Gastrin - Answer-C. CA 15-3 and CA 549
Which tumor marker is associated with cancer of the urinary bladder?
A. CA 125
B. CA19-9
C. CA 50
D. Nuclear matrix protein - Answer-D. Nuclear matrix protein
, What is the primary clinical usefulness of measuring carcinoembryonic antigen?
A. Diagnosis of lung cancer
B. Diagnosis of colorectal cancer
C. Screening for breast cancer
D. Monitoring for recurrence of colon cancer - Answer-D. Monitoring for recurrence
of colon cancer
levels of 89% carboxyhemoglobin saturation of whole blood are commonly found in
which of the following - Answer-fatal carbon monoxide poisoning
Which of the following techniques is a definitive means for both qualitative and
quantitative analysis of drugs of abuse - Answer-gas chromatography coupled with
mass spectrometry
screening methods for drug abuse testing require which of the following assay
characteristics - Answer-they must be analytically sensitive
urine adulteration test strips are designed to detect which of the following - Answer-
all of the above
which of the following biological fluids is the specimen of choice for screening and/or
analyzing drugs of abuse - Answer-urine
imipramine is classified as - Answer-tricyclic antidepressant
the toxic effect of acetaminophen overdose is - Answer-hepatocystic necrosis
THC is the principal active metabolite of which of the following - Answer-marijuana
valium and Librium are examples of which of the following - Answer-
benzodiazepines
identification of the urinary metabolite bezoylecgonine would be useful indetermining
the presence of which of the following compounds - Answer-cytochrome P450
elevated blood levels of lead will result in a deficiency of which of the following
enzymes - Answer-amino levulinic acid dehydratase
lead exposure causes an increase blood concentration in which of the following
analytes - Answer-zinc-pronto porphyrin
which of the following is a xanthene that potentially could interfere with the
determination of theophylline - Answer-caffeine
following the entrance of a drug into the vascular component it will be carried to all
organs and fluid compartments this statement describes which of the following -
Answer-distribution
