PEBC Part I sample questions with verified answers
*A 3 year old child was admitted to the hospital following ingestion of an
overdose of acetylsalicylic acid. The child was semi-comatose, flushed and flaccid.
Her pupils were fixed and dilated. Respirations were deep and rapid. Laboratory
investigation indicated serum salicylate level of 5.8 mmol/L and a urinary pH of
6.*
41 The syndrome of deep and rapid respirations would initially lead to:
a. respiratory acidosis.
b. respiratory alkalosis.
c. renal excretion of acid.
d. marked reduction in body temperature.
e. increased chloride elimination in urine. Ans✓✓✓ b
*A 3 year old child was admitted to the hospital following ingestion of an
overdose of acetylsalicylic acid. The child was semi-comatose, flushed and flaccid.
Her pupils were fixed and dilated. Respirations were deep and rapid. Laboratory
investigation indicated serum salicylate level of 5.8 mmol/L and a urinary pH of
6.*
42 As a result of other mechanisms the child would likely progress to:
a. hyperglycemia.
b. hypoglycemia.
c. metabolic alkalosis.
d. systemic acidosis.
e. renal failure. Ans✓✓✓ d
,*A 3 year old child was admitted to the hospital following ingestion of an
overdose of acetylsalicylic acid. The child was semi-comatose, flushed and flaccid.
Her pupils were fixed and dilated. Respirations were deep and rapid. Laboratory
investigation indicated serum salicylate level of 5.8 mmol/L and a urinary pH of
6.*
43 One form of therapy to hasten the excretion of salicylate involves the
administration of:
a. vasopressin (ADH).
b. probenecid.
c. ammonium chloride.
d. sodium bicarbonate.
e. aluminum hydroxide. Ans✓✓✓ d
*SM is a 34 year old female who, while vacationing in Mexico, began prophylactic
treatment for travellers' diarrhea. Shortly thereafter she complained of a feeling
of fullness in her ears, black stools and a black tongue. SM's previous history
includes an allergy to sulfonamides.*
56 Which of the following drugs could be the cause of SM's complaints?
a. Bismuth subsalicylate
b. Cotrimoxazole
c. Doxycycline
d. Amoxicillin
e. Loperamide Ans✓✓✓ a
,*SM is a 34 year old female who, while vacationing in Mexico, began prophylactic
treatment for travellers' diarrhea. Shortly thereafter she complained of a feeling
of fullness in her ears, black stools and a black tongue. SM's previous history
includes an allergy to sulfonamides.*
57 Am organism commonly implicated in the cause of travellers' diarrhea is:
a. Bacteroides fragilis.
b. Escherichia coli.
c. Clostridium difficile.
d. Listeria monocytogenes.
e. Pseudomonas aeruginosa. Ans✓✓✓ b
*TK is a 63 year old male with chronic kidney disease (CrCl = 29 mL/min/1.73m2)
and gout. He experienced his last gout attack about 2 months ago. Today his toe is
extremely painful, hot, red and swollen. At a walk-in clinic, he receives a
prescription for naproxen 500 mg po bid for 5 days. TK' s other current
medication is pravastatin 20 mg po hs.*
63 What drug therapy problem should the pharmacist identify for TK?
a. Naproxen is inferior to indomethacin for the treatment of acute gout.
b. The duration of naproxen treatment is too short.
c. Naproxen should be avoided in patients taking pravastatin.
d. Naproxen should be avoided in patients with renal dysfunction.
e. The frequency of naproxen dosing is too low. Ans✓✓✓ d
*TK is a 63 year old male with chronic kidney disease (CrCl = 29 mL/min/1.73m2)
and gout. He experienced his last gout attack about 2 months ago. Today his toe is
, extremely painful, hot, red and swollen. At a walk-in clinic, he receives a
prescription for naproxen 500 mg po bid for 5 days. TK' s other current
medication is pravastatin 20 mg po hs.*
64 Following successful resolution of the acute episode, TK's physician decides
that he should initiate allopurinol. TK should be advised to:
a. limit fluid intake.
b. take medication on an empty stomach.
c. use precautions to avoid photosensitivity.
d. report any skin rash or itching to the physician.
e. avoid dairy products or multivitamins within 2 hours of dose. Ans✓✓✓ d
1 Folic acid has tetrahydrofolate coenzyme activity which is based on the:
a. pyrimidine ring.
b. purine ring.
c. pyrazine ring.
d. pteridine ring.
e. pyridine ring. Ans✓✓✓ d
10 Which of the following enzymes catalyzes the synthesis of DNA from viral
RNA?
a. Reverse transcriptase
b. DNA polymerase
c. RNA polymerase
d. Endonuclease
*A 3 year old child was admitted to the hospital following ingestion of an
overdose of acetylsalicylic acid. The child was semi-comatose, flushed and flaccid.
Her pupils were fixed and dilated. Respirations were deep and rapid. Laboratory
investigation indicated serum salicylate level of 5.8 mmol/L and a urinary pH of
6.*
41 The syndrome of deep and rapid respirations would initially lead to:
a. respiratory acidosis.
b. respiratory alkalosis.
c. renal excretion of acid.
d. marked reduction in body temperature.
e. increased chloride elimination in urine. Ans✓✓✓ b
*A 3 year old child was admitted to the hospital following ingestion of an
overdose of acetylsalicylic acid. The child was semi-comatose, flushed and flaccid.
Her pupils were fixed and dilated. Respirations were deep and rapid. Laboratory
investigation indicated serum salicylate level of 5.8 mmol/L and a urinary pH of
6.*
42 As a result of other mechanisms the child would likely progress to:
a. hyperglycemia.
b. hypoglycemia.
c. metabolic alkalosis.
d. systemic acidosis.
e. renal failure. Ans✓✓✓ d
,*A 3 year old child was admitted to the hospital following ingestion of an
overdose of acetylsalicylic acid. The child was semi-comatose, flushed and flaccid.
Her pupils were fixed and dilated. Respirations were deep and rapid. Laboratory
investigation indicated serum salicylate level of 5.8 mmol/L and a urinary pH of
6.*
43 One form of therapy to hasten the excretion of salicylate involves the
administration of:
a. vasopressin (ADH).
b. probenecid.
c. ammonium chloride.
d. sodium bicarbonate.
e. aluminum hydroxide. Ans✓✓✓ d
*SM is a 34 year old female who, while vacationing in Mexico, began prophylactic
treatment for travellers' diarrhea. Shortly thereafter she complained of a feeling
of fullness in her ears, black stools and a black tongue. SM's previous history
includes an allergy to sulfonamides.*
56 Which of the following drugs could be the cause of SM's complaints?
a. Bismuth subsalicylate
b. Cotrimoxazole
c. Doxycycline
d. Amoxicillin
e. Loperamide Ans✓✓✓ a
,*SM is a 34 year old female who, while vacationing in Mexico, began prophylactic
treatment for travellers' diarrhea. Shortly thereafter she complained of a feeling
of fullness in her ears, black stools and a black tongue. SM's previous history
includes an allergy to sulfonamides.*
57 Am organism commonly implicated in the cause of travellers' diarrhea is:
a. Bacteroides fragilis.
b. Escherichia coli.
c. Clostridium difficile.
d. Listeria monocytogenes.
e. Pseudomonas aeruginosa. Ans✓✓✓ b
*TK is a 63 year old male with chronic kidney disease (CrCl = 29 mL/min/1.73m2)
and gout. He experienced his last gout attack about 2 months ago. Today his toe is
extremely painful, hot, red and swollen. At a walk-in clinic, he receives a
prescription for naproxen 500 mg po bid for 5 days. TK' s other current
medication is pravastatin 20 mg po hs.*
63 What drug therapy problem should the pharmacist identify for TK?
a. Naproxen is inferior to indomethacin for the treatment of acute gout.
b. The duration of naproxen treatment is too short.
c. Naproxen should be avoided in patients taking pravastatin.
d. Naproxen should be avoided in patients with renal dysfunction.
e. The frequency of naproxen dosing is too low. Ans✓✓✓ d
*TK is a 63 year old male with chronic kidney disease (CrCl = 29 mL/min/1.73m2)
and gout. He experienced his last gout attack about 2 months ago. Today his toe is
, extremely painful, hot, red and swollen. At a walk-in clinic, he receives a
prescription for naproxen 500 mg po bid for 5 days. TK' s other current
medication is pravastatin 20 mg po hs.*
64 Following successful resolution of the acute episode, TK's physician decides
that he should initiate allopurinol. TK should be advised to:
a. limit fluid intake.
b. take medication on an empty stomach.
c. use precautions to avoid photosensitivity.
d. report any skin rash or itching to the physician.
e. avoid dairy products or multivitamins within 2 hours of dose. Ans✓✓✓ d
1 Folic acid has tetrahydrofolate coenzyme activity which is based on the:
a. pyrimidine ring.
b. purine ring.
c. pyrazine ring.
d. pteridine ring.
e. pyridine ring. Ans✓✓✓ d
10 Which of the following enzymes catalyzes the synthesis of DNA from viral
RNA?
a. Reverse transcriptase
b. DNA polymerase
c. RNA polymerase
d. Endonuclease
