ANCC DOMAIN 1 QUESTIONS AND ANSWERS
GRADED A+ 2025/2026
What .direct-acting .dopamine .receptor .agonist .is .recommended .to .be .used .in .the
.treatment .of .neuroleptic .malignant .syndrome .(NMS) .to .help .lower .the .dopamine
.receptor .blockade?
A. .Dantrolene .(Dantrium)
B. .Benztropine .(Cogentin)
C. .Bromocriptine .(Parlodel)
D. .Trihexyphenidyl .(Artane) .- .CORRECT .ANSWER-C. .Bromocriptine .(Parlodel)
A .74 .y/o .female .present .for .an .evaluation. .The .psychiatric .nurse .practitioner .has .the
.patient .complete .the .mini .mental .status .examination .and .clock .drawing. .The .patient .is
.unable .to .correctly .draw .the .face .of .the .clock. .Which .area .of .the .brain .is .likely .to .have
.compromised .functioning?
A. .Corpus .callosum
B. .Wernicke's .Area
C. .Left .Hemisphere
D. .Right .Hemisphere .- .CORRECT .ANSWER-D. .Right .Hemisphere
Which .of .the .following .statements .reflects .current .understanding .of .neurodevelopment
.and .best .explains .risk-taking .behaviors .of .adolescent .males?
A. .Stimulant .and .substance .use .impairs .judgment .and .cognitive .appraisal
B. .Pruning .of .serotonin .circuits .in .the .adolescent .brain .is .associated .with .increased
.impulsivity
, C. .Maturation .of .the .prefrontal .cortex .continues .into .mid-20s .and .early .30s
D. .Hormonal .flooding, .especially .testosterone .and .oxytocin, .increase .dopamine .levels .in
.the .brain .- .CORRECT .ANSWER-C. .Maturation .of .the .prefrontal .cortex .continues .into .mid-
20s .and .early .30s
What .cytochrome .(CYP) .enzyme .is .implicated .as .a .tobacco .inducer .when .an .individual .is
.treated .on .clozapine?
A. .2C19
B. .1A2
C. .2C9
D. .2D6 .- .CORRECT .ANSWER-B. .1A2
As .a .psychiatric .mental .health .nurse .practitioner, .you .are .aware .of .antipsychotic
.medication .side .effects. .Which .of .the .following .side .effects .of .antipsychotic .medications
.has .an .insidious, .delayed-onset .typically .1 .to .2 .years .after .initiation .of .the .medication?
A. .Sedation
B. .Weight .gain
C. .Tardive .dyskinesia
D. .Dry .mouth .- .CORRECT .ANSWER-C. .Tardive .dyskinesia
Which .mood .stabilizer .is .most .associated .with .a .potentially .life-threatening .rash?
A. .Divalproex .(depakote)
B. .Carbamazepine .(tegretol)
C. .Lithium .(eskalith)
D. .Lamotrigine .(lamictal) .- .CORRECT .ANSWER-D. .Lamotrigine .(lamictal)
The .psychiatric-Mental .Health .Nurse .Practitioner .would .expect .to .see .which .of .the
.following .during .a .physical .exam .for .a .patient .with .bulimia .nervosa?
A. .Alopecia .areata
B. .Tachycardia
GRADED A+ 2025/2026
What .direct-acting .dopamine .receptor .agonist .is .recommended .to .be .used .in .the
.treatment .of .neuroleptic .malignant .syndrome .(NMS) .to .help .lower .the .dopamine
.receptor .blockade?
A. .Dantrolene .(Dantrium)
B. .Benztropine .(Cogentin)
C. .Bromocriptine .(Parlodel)
D. .Trihexyphenidyl .(Artane) .- .CORRECT .ANSWER-C. .Bromocriptine .(Parlodel)
A .74 .y/o .female .present .for .an .evaluation. .The .psychiatric .nurse .practitioner .has .the
.patient .complete .the .mini .mental .status .examination .and .clock .drawing. .The .patient .is
.unable .to .correctly .draw .the .face .of .the .clock. .Which .area .of .the .brain .is .likely .to .have
.compromised .functioning?
A. .Corpus .callosum
B. .Wernicke's .Area
C. .Left .Hemisphere
D. .Right .Hemisphere .- .CORRECT .ANSWER-D. .Right .Hemisphere
Which .of .the .following .statements .reflects .current .understanding .of .neurodevelopment
.and .best .explains .risk-taking .behaviors .of .adolescent .males?
A. .Stimulant .and .substance .use .impairs .judgment .and .cognitive .appraisal
B. .Pruning .of .serotonin .circuits .in .the .adolescent .brain .is .associated .with .increased
.impulsivity
, C. .Maturation .of .the .prefrontal .cortex .continues .into .mid-20s .and .early .30s
D. .Hormonal .flooding, .especially .testosterone .and .oxytocin, .increase .dopamine .levels .in
.the .brain .- .CORRECT .ANSWER-C. .Maturation .of .the .prefrontal .cortex .continues .into .mid-
20s .and .early .30s
What .cytochrome .(CYP) .enzyme .is .implicated .as .a .tobacco .inducer .when .an .individual .is
.treated .on .clozapine?
A. .2C19
B. .1A2
C. .2C9
D. .2D6 .- .CORRECT .ANSWER-B. .1A2
As .a .psychiatric .mental .health .nurse .practitioner, .you .are .aware .of .antipsychotic
.medication .side .effects. .Which .of .the .following .side .effects .of .antipsychotic .medications
.has .an .insidious, .delayed-onset .typically .1 .to .2 .years .after .initiation .of .the .medication?
A. .Sedation
B. .Weight .gain
C. .Tardive .dyskinesia
D. .Dry .mouth .- .CORRECT .ANSWER-C. .Tardive .dyskinesia
Which .mood .stabilizer .is .most .associated .with .a .potentially .life-threatening .rash?
A. .Divalproex .(depakote)
B. .Carbamazepine .(tegretol)
C. .Lithium .(eskalith)
D. .Lamotrigine .(lamictal) .- .CORRECT .ANSWER-D. .Lamotrigine .(lamictal)
The .psychiatric-Mental .Health .Nurse .Practitioner .would .expect .to .see .which .of .the
.following .during .a .physical .exam .for .a .patient .with .bulimia .nervosa?
A. .Alopecia .areata
B. .Tachycardia
