Katzung's Basic And Clinical Pharmacology 16th Edition, (2024)
By Todd W. Vanderah
All Chapters 1-67| 10 Sections| Latest Version With All Detailed Answers| Grade A+
From: [Bestmaxsolutions.stuvia
,SECTION I: BASIC PRINCIPLES ____________________________________________________ 5
Chapter 1: Introduction: The Nature Of Drugs & Drug Development & Regulation _______________________ 5
Chapter 2: Drug Receptors & Pharmacodynamics _________________________________________________ 25
Chapter 3: Pharmacokinetics & Pharmacodynamics: Rational Dosing & The Time Course Of Drug Action ___ 46
Chapter 4: Drug Biotransformation ____________________________________________________________ 60
Chapter 5: Pharmacogenomics ________________________________________________________________ 75
SECTION II: AUTONOMIC DRUGS ________________________________________________ 84
Chapter 6. Introduction To Autonomic Pharmacology _____________________________________________ 84
Chapter 7: Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs______________________________ 105
Chapter 8: Cholinoceptor-Blocking Drugs ______________________________________________________ 123
Chapter 9: Adrenoceptor Agonists & Sympathomimetic Drugs _____________________________________ 142
Chapter 10: Adrenoceptor Antagonist Drugs ____________________________________________________ 160
SECTION III: CARDIOVASCULAR-RENAL DRUGS____________________________________ 179
Chapter 11: Antihypertensive Agents __________________________________________________________ 179
Chapter 12: Vasodilators & The Treatment Of Angina Pectoris _____________________________________ 199
Chapter 13: Drugs Used In Heart Failure _______________________________________________________ 217
Chapter 14: Agents Used In Cardiac Arrhythmias ________________________________________________ 235
Chapter 15: Diuretic Agents _________________________________________________________________ 254
SECTION IV: DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE _______________ 271
Chapter 16: Histamine, Serotonin, & The Ergot Alkaloids _________________________________________ 271
Chapter 17: Vasoactive Peptides _____________________________________________________________ 284
Chapter 18: The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds ______ 293
Chapter 19: Nitric Oxide ____________________________________________________________________ 301
Chapter 20: Drugs Used in Asthma & Chronic Obstructive Pulmonary Disease ________________________ 320
SECTION V: DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM ____________________ 336
Chapter 21: Introduction To The Pharmacology Of CNS Drugs______________________________________ 336
Chapter 22: Sedative-Hypnotic Drugs _________________________________________________________ 351
Chapter 23: The Alcohols ____________________________________________________________________ 370
Chapter 24: Antiseizure Drugs ________________________________________________________________ 386
Chapter 25: General Anesthetics _____________________________________________________________ 405
Chapter 26: Local Anesthetics ________________________________________________________________ 424
Chapter 27: Skeletal Muscle Relaxants_________________________________________________________ 439
Chapter 28: Pharmacologic Management Of Parkinsonism & Other Movement Disorders ______________ 457
, Chapter 29: Antipsychotic Agents & Lithium ____________________________________________________ 474
Chapter 30: Antidepressant Agents ___________________________________________________________ 493
Chapter 31: Opioid Agonists & Antagonists _____________________________________________________ 513
Chapter 32: Drugs Of Abuse _________________________________________________________________ 531
SECTION VI: DRUGS USED TO TREAT DISEASES OF THE BLOOD, INFLAMMATION, & GOUT_ 546
Chapter 33: Agents Used In Cytopenias; Hematopoietic Growth Factors _____________________________ 546
Chapter 34: Drugs Used In Disorders Of Coagulation _____________________________________________ 563
Chapter 35: Agents Used In Dyslipidemia ______________________________________________________ 580
Chapter 36: Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid
Analgesics, & Drugs Used In Gout _____________________________________________________________ 599
SECTION VII: ENDOCRINE DRUGS ______________________________________________ 618
Chapter 37: Hypothalamic & Pituitary Hormones ________________________________________________ 618
Chapter 38: Thyroid & Antithyroid Drugs _______________________________________________________ 635
Chapter 39: Adrenocorticosteroids & Adrenocortical Antagonists __________________________________ 654
Chapter 40: The Gonadal Hormones & Inhibitors ________________________________________________ 673
Chapter 41: Pancreatic Hormones & Glucose-Lowering Drugs ______________________________________ 692
Chapter 42: Agents That Affect Bone Mineral Homeostasis ________________________________________ 711
SECTION VIII: CHEMOTHERAPEUTIC DRUGS ______________________________________ 730
Chapter 43: Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics _________________________ 730
Chapter 44: Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, Oxazolidinones, &
Pleuromutilins ____________________________________________________________________________ 751
Chapter 45: Aminoglycosides & Spectinomycin _________________________________________________ 767
Chapter 46: Sulfonamides, Trimethoprim, & Quinolones __________________________________________ 782
Chapter 47: Antimycobacterial Drugs __________________________________________________________ 797
Chapter 48: Antifungal Agents _______________________________________________________________ 812
Chapter 49: Antiviral Agents _________________________________________________________________ 831
Chapter 50: Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, & Sterilants _______________ 850
Chapter 51: Clinical Use Of Antimicrobial Agents ________________________________________________ 871
Chapter 52: Antiprotozoal Drugs _____________________________________________________________ 887
Chapter 53: Clinical Pharmacology Of The Antihelminthic Drugs ___________________________________ 906
Chapter 54: Cancer Chemotherapy ____________________________________________________________ 924
Chapter 55: Immunopharmacology ___________________________________________________________ 945
SECTION IX: TOXICOLOGY ____________________________________________________ 965
Chapter 56: Introduction To Toxicology: Occupational & Environmental _____________________________ 965
, Chapter 57: Heavy Metal Intoxication & Chelators ______________________________________________ 1000
Chapter 58: Management Of The Poisoned Patient _____________________________________________ 1014
SECTION X: SPECIAL TOPICS __________________________________________________ 1029
Chapter 59: Special Aspects Of Perinatal & Pediatric Pharmacology ________________________________ 1029
Chapter 60: Special Aspects Of Geriatric Pharmacology __________________________________________ 1038
Chapter 61: Dermatologic Pharmacology______________________________________________________ 1045
Chapter 62: Drugs Used In The Treatment Of Gastrointestinal Diseases_____________________________ 1052
Chapter 63: Cannabinoid Drugs _____________________________________________________________ 1070
Chapter 64: Therapeutic & Toxic Potential Of Over-The-Counter Agents ____________________________ 1084
Chapter 65; Dietary Supplements & Herbal Medications _________________________________________ 1104
Chapter 66: Rational Prescribing & Prescription Writing _________________________________________ 1108
Chapter 67: Important Drug Interactions & Their Mechanisms ____________________________________ 1129
,SECTION I: BASIC PRINCIPLES
Chapter 1: Introduction: The Nature Of Drugs & Drug Development & Regulation
Todd W. Vanderah: Katzung's Basic And Clinical Pharmacology 16th Edition, (2024) Test Bank
MULTIPLE CHOICE
1. A Nurse Is Preparing To Administer A New Medication To A Patient In The Hospital.
The Physician Orders A Drug That Has Not Yet Been Fully Tested On Humans But Has
Shown Promise In Animal Studies. Which Phase Of Drug Development Is This Drug In?
A) Phase I
B) Phase Ii
C) Phase Iii
D) Preclinical
ANS: D
Feedback:
Preclinical Trials Are The Initial Phase Of Drug Development Where Drugs Are Tested
On Animals To Assess Their Safety, Dosage, And Potential Efficacy Before Human
Trials. Phase I Trials Are The First Human Trials, Typically Involving Healthy
Volunteers. Phase Ii Trials Test The Drug On Individuals With The Target Disease, And
Phase Iii Trials Involve Large-Scale Testing In A Clinical Population.
2. A Physician Orders A New Drug For A Patient In The Hospital That Is Still
Undergoing Clinical Trials. What Is The Nurse’s Primary Role In This Clinical Trial
Process?
A) Administer The Drug And Monitor For Side Effects
B) Determine If The Drug Is Effective
C) Conduct Independent Research On The Drug’s Mechanism Of Action
D) Evaluate The Drug’s Cost-Effectiveness
,ANS: A
Feedback:
Nurses Play A Vital Role In Clinical Trials By Administering Drugs, Observing The
Patient, And Monitoring For Adverse Effects. Nurses Do Not Typically Determine The
Effectiveness Of The Drug Or Conduct Research On Its Mechanism Of Action. The
Drug’s Cost-Effectiveness Is Typically Evaluated By Pharmacoeconomists, Not Nurses
Or Physicians Involved In Clinical Trials.
3. A Nurse Is Working In A Hospital And Is Asked To Administer A New Medication
That Has Passed Through Phase I And Phase Ii Clinical Trials. What Is Most Likely The
Status Of This Drug?
A) It Is Approved By The Fda For General Use.
B) It Is Still Under Investigation And Not Approved For General Use.
C) It Is Approved For Use In Animals But Not Humans.
D) It Is Only Being Tested On Healthy Human Volunteers.
ANS: B
Feedback:
After Passing Phase I And Phase Ii Trials, A Drug Is Still Undergoing Clinical Testing,
And It Has Not Yet Been Approved By The Fda For General Use. Phase I Involves
Healthy Human Volunteers, And Phase Ii Involves Patients With The Condition The
Drug Is Intended To Treat. Phase Iii Would Follow, Involving Larger Clinical
Populations, Before Fda Approval For General Use.
4. A Nurse Notices That A Patient Has Experienced Severe Dizziness And Confusion
After Starting A New Medication. What Is The Most Likely Role Of The Nurse In This
Situation?
A) Conduct Research To Find The Underlying Cause Of The Symptoms
B) Report The Adverse Effects To The Appropriate Regulatory Authorities
,C) Prescribe A Different Medication To The Patient
D) Perform A Detailed Pharmacokinetic Analysis Of The Drug
ANS: B
Feedback:
Nurses Are Responsible For Observing And Reporting Adverse Effects To The
Appropriate Regulatory Bodies (E.G., The Fda Or Institutional Safety Committees). They
Do Not Conduct Research, Prescribe Medications, Or Perform Complex Pharmacokinetic
Analyses. Reporting Adverse Effects Helps Improve The Safety Of Drug Use.
5. A Nurse Is Preparing To Administer A Drug That Is Classified As A Schedule Iv
Controlled Substance. Which Of The Following Statements Is True Regarding This
Drug?
A) It Has A High Potential For Abuse And No Accepted Medical Use.
B) It Has A Low Potential For Abuse And Accepted Medical Use.
C) It Has A High Potential For Abuse And A Moderate Level Of Accepted Medical Use.
D) It Has No Potential For Abuse And Is Used Only In Emergency Situations.
ANS: B
Feedback:
Schedule Iv Drugs Have A Low Potential For Abuse Relative To Schedule Iii Drugs And
Have Accepted Medical Uses. These Drugs Have Limited Dependence Liability
Compared To Those In Higher Schedules. Schedule I Drugs Have No Accepted Medical
Use, While Schedule Ii Drugs Have A High Abuse Potential.
6. A Nurse Is Working In A Hospital Setting And Is Asked To Help With The
Administration Of A Vaccine. Which Branch Of Pharmacology Best Describes The
Nurse's Role In This Situation?
A) Pharmacodynamics
, B) Pharmacoeconomics
C) Pharmacotherapeutics
D) Pharmacokinetics
ANS: C
Feedback:
Pharmacotherapeutics Is The Branch Of Pharmacology That Deals With The Use Of
Drugs To Prevent, Treat, And Diagnose Disease. Administering A Vaccine Is Part Of
This Branch, As It Involves Using A Drug To Prevent Disease. Pharmacodynamics And
Pharmacokinetics Are Concerned With How Drugs Affect The Body And How The Body
Affects Drugs, Respectively. Pharmacoeconomics Focuses On The Cost Of Drug
Therapy.
7. A Physician Prescribes A Drug For A Patient With A Chronic Illness. The Drug Has
Been Classified As A Category X Drug By The Fda. What Does This Classification
Indicate?
A) The Drug Is Safe To Use During Pregnancy.
B) The Drug Has Unknown Effects During Pregnancy.
C) The Drug Is Contraindicated During Pregnancy Due To Potential Risks.
D) The Drug Is Only Used In Children.
ANS: C
Feedback:
Category X Drugs Are Those That Have Been Shown To Cause Fetal Harm When Used
During Pregnancy, And Therefore, They Are Contraindicated For Use By Pregnant
Women. This Classification Is The Highest Level Of Risk And Represents Medications
That Should Not Be Used During Pregnancy Under Any Circumstances.