Test Bank For Rubin's Pathology: Clinicopathologic Foundations of Medicine 7th Edition by Strayer ISBN:9781451183900, All 34 Chapters Covered, Verified Latest Edition

, Rubin's Pathology: Clinicopathologic Foundations of Medicine Testb
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ank/Studyguide

Chapter 1: Cell Adaptation, Injury and Death
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Ischemia and other toxic injuries increase the accumulation of intracellular calcium as a resu
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1. lt of:
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A) release of stored calcium from the mitochondria.
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B) improved intracellular volume regulation.mi mi mi




C) decreased influx across the cell membrane.mi mi mi mi mi



D) attraction of calcium to fatty infiltrates.
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The patient is found to have liver disease, resulting in the removal of a lobe of his liver.
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2. Adaptation to the reduced size of the liver leads to
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of the remaining liver cells mi mi mi mi


.
A) metaplasia
B) organ atrophy mi



C) compensatory hyperplasia mi



D) physiologic hypertrophy mi




A person eating peanuts starts choking and collapses. His airway obstruction is partial
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ly cleared, but he remains hypoxic until he reaches the hospital. The prolonged cell hy
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3. poxia caused a cerebral infarction and resulting
mi mi in the brain.
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A) caspase activation mi



B) coagulation necrosis mi



C) rapid phagocytosis mi



D) protein p53 deficiency mi mi



Bacteria and viruses cause cell damage by
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4. , which is unique from the intracellula
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r damage caused by other injurious agents.
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A) disrupting the sodium/potassium ATPase pump mi mi mi mi



B) interrupting oxidative metabolism processes mi mi mi



C) replicating and producing continued injury mi mi mi mi




D) decreasing protein synthesis and function mi mi mi mi



The patient has a prolonged interruption in arterial blood flow to his left kidney, causing hy
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5. poxic cell injury and the release of free radicals. Free radicals damage cells by:
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A) destroying phospholipids in the cell membrane.mi mi mi mi mi



B) altering the immune response of the cell.
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,C) disrupting calcium storage in the cell.
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D) inactivation of enzymes and mitochondria. mi mi mi mi



6. Injured cells have impaired flow of substances through the cell membrane as a result of:
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A) increased fat load. mi mi



B) altered permeability.
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C) altered glucose utilization.
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D) increased surface receptors. mi mi



7. Reversible adaptive intracellular responses are initiated by:
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A) stimulus overload. mi



B) genetic mutations. mi



C) chemical messengers. mi



D) mitochondrial DNA. mi



8. Injured cells become very swollen as a result of:
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A) increased cell protein synthesis.
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B) altered cell volume regulation.
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C) passive entry of potassium into the cell.
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D) bleb formation in the plasma membrane.
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A diabetic patient has impaired sensation, circulation, and oxygenation of his feet. He steps
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on a piece of glass, the wound does not heal, and the area tissue becomes necrotic. The ne
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9. crotic cell death is characterized by:
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A) rapid apoptosis.
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B) cellular rupture. mi




C) shrinkage and collapse. mi mi



D) chronic inflammation. mi



A 99-year-
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10. old woman has experienced the decline of cell function associated with age. A group of th
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eories of cellular aging focus on programmed:
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A) changes with genetic influences. mi mi mi



B) elimination of cell receptor sites. mi mi mi mi



C) insufficient telomerase enzyme. mi mi



D) DNA mutation or faulty repair.
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An 89-year-
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old female patient has experienced significant decreases in her mobility and stamina durin
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g a 3-
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11. week hospital stay for the treatment of a femoral head fracture. Which of the following ph
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, enomena most likely accounts for the patients decrease in muscle function
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that underlies her reduced mobility?
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A) Impaired muscle cell metabolism resulting from metaplasia
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B) Dysplasia as a consequence of inflammation during bone remodeling
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C) Disuse atrophy of muscle cells during a prolonged period of immobility
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D) Ischemic atrophy resulting from vascular changes while on bedrest
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A 20-year-
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old college student has presented to her campus medical clinic for a scheduled Papanicolao
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12. u (Pap) smear. The clinician who will interpret the smear will examine cell samples for ev
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idence of: mi



A) changes in cell shape, size, and organization.
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B) the presence of unexpected cell types.
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C) ischemic changes in cell samples. mi mi mi mi




D) abnormally high numbers of cells in a specified field. mi mi mi mi mi mi mi mi



Which of the following pathophysiologic processes is most likely to result in metastatic calci
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13. cation?
A) Benign prostatic hyperplasia mi mi



B) Liver cirrhosis mi



C) Impaired glycogen metabolism mi mi



D) Hyperparathyroidism
Despite the low levels of radiation used in contemporary radiologic imaging, a radiology te
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nician is aware of the need to minimize her exposure to ionizing radiation. What is the prim
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14. y rationale for the technicians precautions?
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A) Radiation stimulates pathologic cell hypertrophy and hyperplasia.
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B) Radiation results in the accumulation of endogenous waste products in the cytoplasm.
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C) Radiation interferes with DNA synthesis and mitosis.
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D) Radiation decreases the action potential of rapidly dividing cells.
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The parents of a 4-year-
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old girl have sought care because their daughter has admitted to chewing and swallowing i
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15. mported toy figurines that have been determined to be made of lead. Which of the followin
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g blood tests should the care team prioritize?
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A) White blood cell levels with differential
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B) Red blood cell levels and morphology
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C) Urea and creatinine levels
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D) Liver function panel mi mi