CPJE - Brand/Generic Questions with
Correct Answers
acetylsalicylic acid Aspirin/Ecotren
diclofenac Voltaren DR/Voltaren ER
PO (DR, ER, IR, powder), PR, IV(bolus)
MOA: COX-1 and -2 inhibitor
Dose: 50mg TID, 100mg daily, 37.5mg IV q6hr
*Use not rec in severe renal disease
SE: Edema, HTN, HA, rash, GI
*NSAIDs increase risk of serious CV events
Stor/Stab: IV-protect from light
diclofenac/misoprostol Arthrotec
PO - OA and RA
,MOA: COX-1 and -2 inhibitor; prostaglandin analog
Dose: 50mg/200mcg 3-4x/d
*Give after meal to decrease GI upset
SE: GI, increase ALT
*NSAIDs increase risk of serious CV events
*USE IS CI IN PREGNANT WOMEN*
ibuprofen Motrin/Advil/Caldolor
PO(tab/susp), IV(must be diluted-D5W/NS/LR)
MOA: COX-1 and -2 inhibitor; antipyretic, anti-infla
Dose: 400-800mg q4-6hr; max of 3200mg/d
*Pts should be well hydrates prior to IV admin
SE: Edema, rash, GI, increase LFTs
*NSAIDs increase risk of serious CV events
ketoprofen Orudis
,PO(EC, IR, ER), PR
MOA: Cox-1 and -2 inhibitor, antipyretic
Dose: 25-50mg 4x/d, 200mg daily
*max dose of 100mg/d in severe renal impairment
SE: GI, abn LFTs, edema
*NSAIDs increase risk of serious CV events
Stor/Stab: protect from light
oxaprozin Daypro
PO
MOA: Cox-1 and -2 inhibitor, antipyretic
Dose: 1200mg/day - 600mg in renal/HD
SE: Edema, confusion, GI, increase LFTs
*NSAIDs increase risk of serious CV events
Stor/Stab: protect, keep bottle air-tight
ketorolac Acular/Toradol
, Opht, PO, IM(slow/deep), IV(bolus over 15 sec)
MOA: Cox-1 and -2 inhibitor, antipyretic
Dose: 1 drop QID, 15-30mg q6hr IV; 10mg q4-6hr PO; max of 120mg/d
*Not to be used more than 5 days
*Decrease by 50% in mild renal failure
SE: Burning (Acular), HA, GI, dizziness
*NSAIDs increase risk of serious CV events
Stor/Stab: Protect from light -inj is slightly yellow
indomethacin Indocin/Tivorbex
PO (IR, ER), PR, IV(over 20-30min)
MOA: Cox-1 and -2 inhibitor, antipyretic
Dose: 25mg 2-3x/d, 75mg/d; max of 200mg/150mg
*Not rec in renal failure
SE: HA, GI, dizziness, swelling
*NSAIDs increase risk of serious CV events
Correct Answers
acetylsalicylic acid Aspirin/Ecotren
diclofenac Voltaren DR/Voltaren ER
PO (DR, ER, IR, powder), PR, IV(bolus)
MOA: COX-1 and -2 inhibitor
Dose: 50mg TID, 100mg daily, 37.5mg IV q6hr
*Use not rec in severe renal disease
SE: Edema, HTN, HA, rash, GI
*NSAIDs increase risk of serious CV events
Stor/Stab: IV-protect from light
diclofenac/misoprostol Arthrotec
PO - OA and RA
,MOA: COX-1 and -2 inhibitor; prostaglandin analog
Dose: 50mg/200mcg 3-4x/d
*Give after meal to decrease GI upset
SE: GI, increase ALT
*NSAIDs increase risk of serious CV events
*USE IS CI IN PREGNANT WOMEN*
ibuprofen Motrin/Advil/Caldolor
PO(tab/susp), IV(must be diluted-D5W/NS/LR)
MOA: COX-1 and -2 inhibitor; antipyretic, anti-infla
Dose: 400-800mg q4-6hr; max of 3200mg/d
*Pts should be well hydrates prior to IV admin
SE: Edema, rash, GI, increase LFTs
*NSAIDs increase risk of serious CV events
ketoprofen Orudis
,PO(EC, IR, ER), PR
MOA: Cox-1 and -2 inhibitor, antipyretic
Dose: 25-50mg 4x/d, 200mg daily
*max dose of 100mg/d in severe renal impairment
SE: GI, abn LFTs, edema
*NSAIDs increase risk of serious CV events
Stor/Stab: protect from light
oxaprozin Daypro
PO
MOA: Cox-1 and -2 inhibitor, antipyretic
Dose: 1200mg/day - 600mg in renal/HD
SE: Edema, confusion, GI, increase LFTs
*NSAIDs increase risk of serious CV events
Stor/Stab: protect, keep bottle air-tight
ketorolac Acular/Toradol
, Opht, PO, IM(slow/deep), IV(bolus over 15 sec)
MOA: Cox-1 and -2 inhibitor, antipyretic
Dose: 1 drop QID, 15-30mg q6hr IV; 10mg q4-6hr PO; max of 120mg/d
*Not to be used more than 5 days
*Decrease by 50% in mild renal failure
SE: Burning (Acular), HA, GI, dizziness
*NSAIDs increase risk of serious CV events
Stor/Stab: Protect from light -inj is slightly yellow
indomethacin Indocin/Tivorbex
PO (IR, ER), PR, IV(over 20-30min)
MOA: Cox-1 and -2 inhibitor, antipyretic
Dose: 25mg 2-3x/d, 75mg/d; max of 200mg/150mg
*Not rec in renal failure
SE: HA, GI, dizziness, swelling
*NSAIDs increase risk of serious CV events
