PHAR 100 Questions and Correct Answers/ Latest Update / Already Graded

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PHAR 100 Questions and Correct
Answers/ Latest Update / Already
Graded
Phase One Drug Trial


Ans: Small number of people


Absorption, distribution, elimination, and adverse effects are monitored




Phase Two Drug Trial


Ans: Small number of people


Determines if drug is effective in treatment




Phase Three Drug Trial


Ans: Large number of people


Safety of drug is carefully studied




Potency

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Ans: Amount of drug that must be given to obtain a response




Efficacy


Ans: Maximum effect of the drug




Paul Ehrlich


Ans: Organoarsenic compounds


Salvarsan: syphilis treatment




Gerhard Domagk


Ans: Sulfonamides


Prontosil: streptococcus




Antimetabolites

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Ans: Act against substances required for metabolism of an organism


Example: sulfanilamide




Sulfanilamide


Ans: Antimetabolite




Therapeutic Index


Ans: Lethal Dose (Toxicity) ÷ Effective Dose


Higher means safer




Parenteral Routes


Ans: Intramuscular


Subcutaneous


Intravenous




Enteral Routes

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Ans: Mouth


Rectal


Under Tongue




Drug Dependence


Ans: Physical dependence


Psychological dependence


Tolerance




Abuse Potential


Ans: Dependence liability


Availability of drug


Harmfulness




CNS Depressants