©THESTAR 2025 ALL RIGHTS RESERVED 11:24 PM A+
Comprehensive Basic Science Exam (CBSE)
Review Set I. Exam Questions And Answers
|Latest 2025 | Guaranteed Pass.
Chagas Disease - Answer✔Caused by Trypanosoma cruzi parasite passed in the feces of
Reduviidae/kissing bug
Penetrates broken skin or intact mucous membranes forming a pseudocyst releasing
inflammatory infiltrates into myocytes; stains with Giemsa & Wright
Romana sign occurs when portal of entry is the conjunctiva or eyelid
May resulting in:
Enlarged heart- CHF, sudden cardiac arrest
Enlarged esophagus- difficulty swallowing
Enlarged colon- abdominal pain or constipation
Treat with benznidazole or nifurtimox
Monocytes - Answer✔cell with half-moon shaped nucleus that participates in phagocytosis
Chronic graft rejection - Answer✔multifactorial but typically involves arteriosclerosis
HLA-B27 - Answer✔PAIR:
Psoriasis
Ankylosing spondylitis- chronic synovitis destroying cartilage typically in young men
Inflammatory bowel dz- Crohn's & UC
1|Page
, ©THESTAR 2025 ALL RIGHTS RESERVED 11:24 PM A+
Reactive Arthritis-
Reactive Arthritis - Answer✔Arthritis as a reaction to a bacterial infection such as
Campylobacter, Chlamydia, Salmonella, Shigella, or Ureaplasma.
Associated with conjunctivitis & uveitis
Gaucher (Type 1) - Answer✔AR Lysosomal storage disease
Accumulation of sphingolipid glucocerebroside
Most common
Wrinkled tissue paper
I Cell disease - Answer✔Failure of Golgi apparatus to phosphorylate mannose 6-phosphate the
marker to export enzymes to lysosomes resulting in accumulation of lysosomal enzymes in
serum
Nitroblue tetrazolium test - Answer✔Aqualitative test to determine defects in NADPH oxidase
Negative: CGD
Positive: Acute Hepatitis, Mono
CGD (chronic granulomatous disease) - Answer✔inability to produce NADPH oxidase;
susceptible to Cat + organisms; elevated neutrophils w/ normal T cell
Gp91 phox subunit: heme binding subunit of superoxide generating NADPH
Treat with interferon gamma
Clarithromycin (macrolide) - Answer✔ADR of metallic taste & GI
Codeine - Answer✔ADR resp. depression, euphoria, & constipation
Cyclobenzaprine - Answer✔Structurally similar to TCAs w/ anticholinergic side effects used for
relief of muscle spasms
2|Page
, ©THESTAR 2025 ALL RIGHTS RESERVED 11:24 PM A+
May exacerbate glaucoma
Naproxen - Answer✔ADR of GI & renal (in elderly)
Timolol - Answer✔Used in HTN & glaucoma; ADR of bradycardia & worsening asthma
Bacterial vaginosis - Answer✔Sloughed mucosal cells = clue cells
Trichomoniasis - Answer✔Cilated, motile trophozoites w/ corkscrew-like motility
Autism - Answer✔Lack of eye contact, verbal communication, & separation anxiety; repetitious
behavior
Emphysema - Answer✔Decreased FEV1/FVC ratio, normal FVC; TLC, FRC, & RV increase
Parathyroid hormone(PTH) vs phosphate in hypercalcemia - Answer✔PTH: rapid & direct
Phosphate: slow & indirect
ANP: - Answer✔Afib, Ch-1p, NPPA gene mutation causing binding interference,- decrease cGMP
Failure of development of 3rd or 4th pharyngeal pouches - Answer✔DiGeorge syndrome
(CATCH 22): truncus arteriosus & agenesis of parathyroid glands
May also be associated w/ failure of thymus to develop -> T lymphocytes w/ CD3 marker
Huntington disease - Answer✔PCR is the most common method to est. # of CAGs
Both the coding & template strands bind the forward & reverse primers on 3' end
Pyrmidine Dimers - Answer✔BRAF gain of function mutation causing covalant thymine (or
Cystine) bonds normally repaired thru NER in the G1 phase by endonuclease recognition then
excision (DNA polymerase then fills; ligase then reseals)
Xeroderma pigmentosum - Answer✔Mutation of NER endonuclease from UV radiation
disrupting DNA replication due to the oligonucleotides remaining damaged
3|Page
Comprehensive Basic Science Exam (CBSE)
Review Set I. Exam Questions And Answers
|Latest 2025 | Guaranteed Pass.
Chagas Disease - Answer✔Caused by Trypanosoma cruzi parasite passed in the feces of
Reduviidae/kissing bug
Penetrates broken skin or intact mucous membranes forming a pseudocyst releasing
inflammatory infiltrates into myocytes; stains with Giemsa & Wright
Romana sign occurs when portal of entry is the conjunctiva or eyelid
May resulting in:
Enlarged heart- CHF, sudden cardiac arrest
Enlarged esophagus- difficulty swallowing
Enlarged colon- abdominal pain or constipation
Treat with benznidazole or nifurtimox
Monocytes - Answer✔cell with half-moon shaped nucleus that participates in phagocytosis
Chronic graft rejection - Answer✔multifactorial but typically involves arteriosclerosis
HLA-B27 - Answer✔PAIR:
Psoriasis
Ankylosing spondylitis- chronic synovitis destroying cartilage typically in young men
Inflammatory bowel dz- Crohn's & UC
1|Page
, ©THESTAR 2025 ALL RIGHTS RESERVED 11:24 PM A+
Reactive Arthritis-
Reactive Arthritis - Answer✔Arthritis as a reaction to a bacterial infection such as
Campylobacter, Chlamydia, Salmonella, Shigella, or Ureaplasma.
Associated with conjunctivitis & uveitis
Gaucher (Type 1) - Answer✔AR Lysosomal storage disease
Accumulation of sphingolipid glucocerebroside
Most common
Wrinkled tissue paper
I Cell disease - Answer✔Failure of Golgi apparatus to phosphorylate mannose 6-phosphate the
marker to export enzymes to lysosomes resulting in accumulation of lysosomal enzymes in
serum
Nitroblue tetrazolium test - Answer✔Aqualitative test to determine defects in NADPH oxidase
Negative: CGD
Positive: Acute Hepatitis, Mono
CGD (chronic granulomatous disease) - Answer✔inability to produce NADPH oxidase;
susceptible to Cat + organisms; elevated neutrophils w/ normal T cell
Gp91 phox subunit: heme binding subunit of superoxide generating NADPH
Treat with interferon gamma
Clarithromycin (macrolide) - Answer✔ADR of metallic taste & GI
Codeine - Answer✔ADR resp. depression, euphoria, & constipation
Cyclobenzaprine - Answer✔Structurally similar to TCAs w/ anticholinergic side effects used for
relief of muscle spasms
2|Page
, ©THESTAR 2025 ALL RIGHTS RESERVED 11:24 PM A+
May exacerbate glaucoma
Naproxen - Answer✔ADR of GI & renal (in elderly)
Timolol - Answer✔Used in HTN & glaucoma; ADR of bradycardia & worsening asthma
Bacterial vaginosis - Answer✔Sloughed mucosal cells = clue cells
Trichomoniasis - Answer✔Cilated, motile trophozoites w/ corkscrew-like motility
Autism - Answer✔Lack of eye contact, verbal communication, & separation anxiety; repetitious
behavior
Emphysema - Answer✔Decreased FEV1/FVC ratio, normal FVC; TLC, FRC, & RV increase
Parathyroid hormone(PTH) vs phosphate in hypercalcemia - Answer✔PTH: rapid & direct
Phosphate: slow & indirect
ANP: - Answer✔Afib, Ch-1p, NPPA gene mutation causing binding interference,- decrease cGMP
Failure of development of 3rd or 4th pharyngeal pouches - Answer✔DiGeorge syndrome
(CATCH 22): truncus arteriosus & agenesis of parathyroid glands
May also be associated w/ failure of thymus to develop -> T lymphocytes w/ CD3 marker
Huntington disease - Answer✔PCR is the most common method to est. # of CAGs
Both the coding & template strands bind the forward & reverse primers on 3' end
Pyrmidine Dimers - Answer✔BRAF gain of function mutation causing covalant thymine (or
Cystine) bonds normally repaired thru NER in the G1 phase by endonuclease recognition then
excision (DNA polymerase then fills; ligase then reseals)
Xeroderma pigmentosum - Answer✔Mutation of NER endonuclease from UV radiation
disrupting DNA replication due to the oligonucleotides remaining damaged
3|Page
