ONCOLOGY CERTIFICATION – CHEMO
QUESTIONS & ANSWERS(RATED A+)
vesicants - ANSWER bleomycin, carmustine, cisplatin, daunorubicin, doxorubicin,
etposide, idarubicin, melphalan, taxol, vincristine
cisplatin antidote - ANSWER sodium thiosulfate
doxorubicin antidote - ANSWER Dexrazoxane
vincristine antidote - ANSWER hyaluronidase
Alkylating agents - ANSWER busulfan, cytoxan, melphalan, ifosfamide, carmustine; cell
cycle non-specific; affects heme, GI, reproductive
antimetabolites - ANSWER methotrexate, 5-FU, cytarabine, gemcitabine, fludarabine;
cell cycle specific, affect counts & GI
platinum compounds - ANSWER cisplatin, carboplatin, oxaliplatin; cell cycle non-
specific; affects heme, GI, neuro, and urinary
topoisomerase targeting agents - ANSWER ironitecan, anthracyclines (daunorubicin,
doxorubicin, idarubicin)
Microtubule targeting agents - ANSWER vincristine, taxanes (paclitaxel and docetaxel);
cell-cycle specific, affects heme, skin, neuro, reproductive
Chemos likely to cause nausea - ANSWER carboplatin, carmustine, cisplatin, cytoxan,
cytarabine, doxorubicin, melphalan, MTX
Chemo likely to cause alopecia - ANSWER cytoxan, daunorubicin, doxorubicin,
docetaxel, etoposide, idarubicine, ifosfamide, paclitaxel
cytoxan - ANSWER high dose needs daily EKG and UA, risk of hemorrhagic cystitis,
need vigorous hydration, mesna, lasix, void q2hrs; risk of cardiac tamponade
cytarabine - ANSWER high doses require cerebellar check, risk of chemical
conjunctivitis, use steroid eye drops
daunorubicin - ANSWER VESICANT, can be hepato/cardiotoxic, urine may be
orange/red for 48 hrs
docetaxel - ANSWER Premeds of decadron for 3-5 days (prevent severe fluid retention
& pulmonary edema), benadryl, pepcid; risk of cardiotoxicity
QUESTIONS & ANSWERS(RATED A+)
vesicants - ANSWER bleomycin, carmustine, cisplatin, daunorubicin, doxorubicin,
etposide, idarubicin, melphalan, taxol, vincristine
cisplatin antidote - ANSWER sodium thiosulfate
doxorubicin antidote - ANSWER Dexrazoxane
vincristine antidote - ANSWER hyaluronidase
Alkylating agents - ANSWER busulfan, cytoxan, melphalan, ifosfamide, carmustine; cell
cycle non-specific; affects heme, GI, reproductive
antimetabolites - ANSWER methotrexate, 5-FU, cytarabine, gemcitabine, fludarabine;
cell cycle specific, affect counts & GI
platinum compounds - ANSWER cisplatin, carboplatin, oxaliplatin; cell cycle non-
specific; affects heme, GI, neuro, and urinary
topoisomerase targeting agents - ANSWER ironitecan, anthracyclines (daunorubicin,
doxorubicin, idarubicin)
Microtubule targeting agents - ANSWER vincristine, taxanes (paclitaxel and docetaxel);
cell-cycle specific, affects heme, skin, neuro, reproductive
Chemos likely to cause nausea - ANSWER carboplatin, carmustine, cisplatin, cytoxan,
cytarabine, doxorubicin, melphalan, MTX
Chemo likely to cause alopecia - ANSWER cytoxan, daunorubicin, doxorubicin,
docetaxel, etoposide, idarubicine, ifosfamide, paclitaxel
cytoxan - ANSWER high dose needs daily EKG and UA, risk of hemorrhagic cystitis,
need vigorous hydration, mesna, lasix, void q2hrs; risk of cardiac tamponade
cytarabine - ANSWER high doses require cerebellar check, risk of chemical
conjunctivitis, use steroid eye drops
daunorubicin - ANSWER VESICANT, can be hepato/cardiotoxic, urine may be
orange/red for 48 hrs
docetaxel - ANSWER Premeds of decadron for 3-5 days (prevent severe fluid retention
& pulmonary edema), benadryl, pepcid; risk of cardiotoxicity
