NR 283 INFLAMMATORY AND COANGULATIVE
PATHOPHYSIOLOGY 355 exams with accurate
answers graded A+
The hemorrhagic problems associated with scurvy are due to a deficiency of
_________, which is a cofactor required for collagen synthesis.
A. Vitamin C
B. Prothrombin
C. Vitamin K
D. Protein C
Correct Answer: A
The number of platelets an average megakaryocyte generates is
approximately
A. 25-50
B. 50-200
C. 200-500
D. 2000-4000
Correct Answer: D
Which of the following is not a cause of thrombocytopenia?
A. Splenomegaly
B. Chemotherapy
C. Increased thrombopoietin
,D. Aplastic anemia
Correct Answer: C
Platelets interacting with and binding to other platelets is referred to as
A. Adhesion
B. Aggregation
C. Release
D. Retraction
Correct Answer: B
In platelet aggregation studies, certain aggregating agents induce a biphasic
aggregation curve. This second phase aggregation curve. This second phase
of aggregation is directly related to
A. Formation of fibrin
B. Changes in platelet shape
C. Release of endogenous ADP
D. Release of platelet factor 3
Correct Answer: C
A platelet aggregation agent that characteristically yields a biphasic curve
when used in optimal concentration is
A. Arachidonic acid
B. Collagen
C. Epinephrine
D. Ristocetin
,Correct Answer: C
The platelet aggregation pattern drawn below is characteristic of the
aggregating agent
See SUCCESS pg 397
A. ADP
B. Collagen
C. Ristocetin
D. Thrombin
Correct Answer: B
The operating principle of a platelet aggregometer is best described as
A. Aggregation on a foreign surface: Platelet aggregation is directly
proportional to the difference in platelet counts performed before and after
platelet-rich plasma is passed through a column of glass beads.
B. Change in optical density: As platelets aggregate, the optical density of
the platelet-rich plasma decreases.
C. Electrical impedance: Platelet aggregates are counted as they pass
through an aperture, temporarily interrupting the flow of current between
two electrodes.
D. Pulse editing: Editing electronically generated pulses can differentiate the
number of free platelets versus platelet aggregates
Correct Answer: B
Of the following therapeutic agent, those considered to be antiplatelet
medications are
, A. Aspirin and Plavix
B. Coumadin and heparin
C. Heparin and protamine sulfate
D. Tissue plasminogen activator and streptokinase
Correct Answer: A
A potent inhibitor of platelet aggregation released by endothelial cells is
A. Epinephrine
B. Prostacyclin
C. Ristocetin
D. Thromboxane A2
Correct Answer: B
The reference value for mean platelet volume (MPV) is approxiamtely
A. 2-4 fL
B. 5-7 fL
C. 8-10 fL
D. 11-14 fL
Correct Answer: C
The platelet parameter PDW refers to the
A. Average platelet volume
B. Call weight versus density
C. Capacity to adhere to foreign surfaces
PATHOPHYSIOLOGY 355 exams with accurate
answers graded A+
The hemorrhagic problems associated with scurvy are due to a deficiency of
_________, which is a cofactor required for collagen synthesis.
A. Vitamin C
B. Prothrombin
C. Vitamin K
D. Protein C
Correct Answer: A
The number of platelets an average megakaryocyte generates is
approximately
A. 25-50
B. 50-200
C. 200-500
D. 2000-4000
Correct Answer: D
Which of the following is not a cause of thrombocytopenia?
A. Splenomegaly
B. Chemotherapy
C. Increased thrombopoietin
,D. Aplastic anemia
Correct Answer: C
Platelets interacting with and binding to other platelets is referred to as
A. Adhesion
B. Aggregation
C. Release
D. Retraction
Correct Answer: B
In platelet aggregation studies, certain aggregating agents induce a biphasic
aggregation curve. This second phase aggregation curve. This second phase
of aggregation is directly related to
A. Formation of fibrin
B. Changes in platelet shape
C. Release of endogenous ADP
D. Release of platelet factor 3
Correct Answer: C
A platelet aggregation agent that characteristically yields a biphasic curve
when used in optimal concentration is
A. Arachidonic acid
B. Collagen
C. Epinephrine
D. Ristocetin
,Correct Answer: C
The platelet aggregation pattern drawn below is characteristic of the
aggregating agent
See SUCCESS pg 397
A. ADP
B. Collagen
C. Ristocetin
D. Thrombin
Correct Answer: B
The operating principle of a platelet aggregometer is best described as
A. Aggregation on a foreign surface: Platelet aggregation is directly
proportional to the difference in platelet counts performed before and after
platelet-rich plasma is passed through a column of glass beads.
B. Change in optical density: As platelets aggregate, the optical density of
the platelet-rich plasma decreases.
C. Electrical impedance: Platelet aggregates are counted as they pass
through an aperture, temporarily interrupting the flow of current between
two electrodes.
D. Pulse editing: Editing electronically generated pulses can differentiate the
number of free platelets versus platelet aggregates
Correct Answer: B
Of the following therapeutic agent, those considered to be antiplatelet
medications are
, A. Aspirin and Plavix
B. Coumadin and heparin
C. Heparin and protamine sulfate
D. Tissue plasminogen activator and streptokinase
Correct Answer: A
A potent inhibitor of platelet aggregation released by endothelial cells is
A. Epinephrine
B. Prostacyclin
C. Ristocetin
D. Thromboxane A2
Correct Answer: B
The reference value for mean platelet volume (MPV) is approxiamtely
A. 2-4 fL
B. 5-7 fL
C. 8-10 fL
D. 11-14 fL
Correct Answer: C
The platelet parameter PDW refers to the
A. Average platelet volume
B. Call weight versus density
C. Capacity to adhere to foreign surfaces
