CLOZARIL
GENERIC NAME: CLOZAPINE
Drug Class: Antipsychotic
NAMES PURPOSE/THERAPEUTIC USES
Generic Name: Clozapine • Used to treat disorders including schizophrenia and
schizoaffective disorder
Brand Name(s): Clozaril • Works by restoring the balance of certain neurotransmitters in
the brain
• Decreases positive and negative symptoms of schizophrenia
including hallucinations and suicidal ideation
DIAGNOSES TREATED
Side Effects/Adverse Reactions
◦ SCHIZOPHRENIA
Orthostatic hypotension Weight gain
◦ SCHIZOAFFECTIVE Hypotension Nausea and vomiting
DISORDER Dry mouth and drooling Visual changes
Tremors Acute confusion
Constipation Agitation
Drowsiness Hypertension
DOSAGING Dizziness Cardiac arrythmia
Fever Neutropenia
Tablet EPS Neuroleptic malignant syndrome
25mg, 50mg, 100mg, 200mg
Nursing Considerations
Assess for fall risk
ADDITIONAL INFO Monitor for S/S of EPS, NMS, and neutropenia
Monitor S/S of hepatotoxicity
Encourage fluid intake, high fiber diet, and exercise to prevent constipation
Smoking can decrease levels
Monitor blood sugar in diabetic patients
If discontinued for 2 days or more, do not Monitor cholesterol levels and assess risk of heart disease
restart; notify healthcare provider for new
dosing instructions
Contraindications
ANC monitoring may be required Hypersensitivity
Bone marrow depression
Uncontrolled epilepsy
Anticholinergic effects with other agents having anticholinergic properties
GENERIC NAME: CLOZAPINE
Drug Class: Antipsychotic
NAMES PURPOSE/THERAPEUTIC USES
Generic Name: Clozapine • Used to treat disorders including schizophrenia and
schizoaffective disorder
Brand Name(s): Clozaril • Works by restoring the balance of certain neurotransmitters in
the brain
• Decreases positive and negative symptoms of schizophrenia
including hallucinations and suicidal ideation
DIAGNOSES TREATED
Side Effects/Adverse Reactions
◦ SCHIZOPHRENIA
Orthostatic hypotension Weight gain
◦ SCHIZOAFFECTIVE Hypotension Nausea and vomiting
DISORDER Dry mouth and drooling Visual changes
Tremors Acute confusion
Constipation Agitation
Drowsiness Hypertension
DOSAGING Dizziness Cardiac arrythmia
Fever Neutropenia
Tablet EPS Neuroleptic malignant syndrome
25mg, 50mg, 100mg, 200mg
Nursing Considerations
Assess for fall risk
ADDITIONAL INFO Monitor for S/S of EPS, NMS, and neutropenia
Monitor S/S of hepatotoxicity
Encourage fluid intake, high fiber diet, and exercise to prevent constipation
Smoking can decrease levels
Monitor blood sugar in diabetic patients
If discontinued for 2 days or more, do not Monitor cholesterol levels and assess risk of heart disease
restart; notify healthcare provider for new
dosing instructions
Contraindications
ANC monitoring may be required Hypersensitivity
Bone marrow depression
Uncontrolled epilepsy
Anticholinergic effects with other agents having anticholinergic properties
