GENETICS EXAM 4 TEST BANK QUESTIONS WITH
100% SOLVED -GRADED A+ VERIFIED 2025 - 2026
UPDATE
The subunit(s) of an E. coli RNA polymerase that recognize the promoter sequence in the DNA is/are: -
ANS-sigma (initial step of RNA synthesis and transcription is RNA polymerase sigma binding to promoter)
The nucleotide sequence TATAAT is commonly associated with: - ANS-the -10 region of bacterial
chromosomes
An intrinsic transcriptional terminator in a prokaryotic cell would likely be: - ANS-a nucleotide sequence
that forms a hairpin with a GC-rich stem followed by a string of U's when transcribed
The bonds that bind the alpha and beta subunits of an enzyme to each other are in fact responsible for
the protein's:
a) primary structure
b) secondary structure
c) tertiary structure
d) quaternary structure - ANS-secondary structure
An example of a developmentally regulated gene family would be: - ANS-globin genes
Dicer and RISC are involved in the process known as: - ANS-RNA [gene] silencing
Which of the following is NOT an example of a posttranslational modification? a) N-terminal amino
acid(s) commonly removed or modified b) Signal/targeting peptide removal c) Phosphorylation,
methylation, acetylation d) glycosylation e) All of the above are example of PM - ANS-All of the above
are examples of posttranslational modifications
Which of the following is NOT an example of a posttranscriptional modification? a) Capping the 5' end of
a pre-mRNA b) intron removal c) RNA editing d) addition of poly(a) to the 5' end of a pre-mRNA e) all of
the above are correct examples - ANS-e) all of the the above are correct examples of common
posttranscriptional modifications of RNAs in higher Eukaryotes
The simple test used to assess mutagenicity of compounds using Salmonella auxotrophs was developed
by: - ANS-Bruce Ames
Transposable elements were first discovered by Barbara McClintock who was studying what organism? -
ANS-Zea Mays
, A human genetic disorder that results from an inability to carry out excision repair of pyrimidine dimers
is: - ANS-xeroderma pigmentosum
A human gene is found to have a number of CpG dinucleotides that are methylated at the C base. It is
very likely that this gene: - ANS-is turned off
A very strong indicator that cancer involves the mutation of multiple genes is the fact that: - ANS-The
annual incidence rate of all forms of cancer goes up with age
A group of genes that normally regulate cell cycle checkpoints and/or initiate the process of apoptosis
would be the: - ANS-signal transduction pathway encoding genes
An enhanceosome is very likely to have: - ANS-DNA-binding domain
In the context of the trp operon of E. coli, the molecule tryptophan is the: - ANS-corepressor
The single human gene whose mutation is associated most commonly with the cancerous state is: - ANS-
p53
An example of gene expression that is regulated by altering the half-life of the mRNA is: - ANS-Tubulin
expression in eukaryotes
An example of a gene or genes that are regulated by catabolite repression in yeast would be: - ANS-GAL
10 and GAL 1
A chromosome territory refers to: - ANS-A discrete domain of the nucleus occupied by a chromosome
The trp repressor binds to the region of the operon best referred to as the: - ANS-operator
Which of the following is an example of DNA binding motif? - ANS-helix-turn-helix
A process that can lead to the generation of multiple/different variants of an mRNA from a single
primary transcript is: - ANS-RNA editing (alternative splicing)
A mutation in a gene changes a codon in the expressed mRNA from UUU to UAA. Based upon your
knowledge of the genetic code and gene expression, this mutation would be BEST called a/an: - ANS-
nonsense mutation
Many/most of the genes associated with an inherited increased risk for specific forms of cancer [i.e. not
all forms of cancer] are: - ANS-tumor suppressor genes
An example of a single mutation that would likely lead directly to constitutive expression of the E. coli
trp operon would be: a) a nonsense mutation in the trpR gene b) a deletion of the trp operator region c)
a promoter mutation d) a nonsense mutation in the CAP gene e) No single mutation is likely to give
constitutive expression of this operon in E. coli - ANS-A deletion of the trp operator region constitutive =
transcribed continually Facultative = transcribed when needed
100% SOLVED -GRADED A+ VERIFIED 2025 - 2026
UPDATE
The subunit(s) of an E. coli RNA polymerase that recognize the promoter sequence in the DNA is/are: -
ANS-sigma (initial step of RNA synthesis and transcription is RNA polymerase sigma binding to promoter)
The nucleotide sequence TATAAT is commonly associated with: - ANS-the -10 region of bacterial
chromosomes
An intrinsic transcriptional terminator in a prokaryotic cell would likely be: - ANS-a nucleotide sequence
that forms a hairpin with a GC-rich stem followed by a string of U's when transcribed
The bonds that bind the alpha and beta subunits of an enzyme to each other are in fact responsible for
the protein's:
a) primary structure
b) secondary structure
c) tertiary structure
d) quaternary structure - ANS-secondary structure
An example of a developmentally regulated gene family would be: - ANS-globin genes
Dicer and RISC are involved in the process known as: - ANS-RNA [gene] silencing
Which of the following is NOT an example of a posttranslational modification? a) N-terminal amino
acid(s) commonly removed or modified b) Signal/targeting peptide removal c) Phosphorylation,
methylation, acetylation d) glycosylation e) All of the above are example of PM - ANS-All of the above
are examples of posttranslational modifications
Which of the following is NOT an example of a posttranscriptional modification? a) Capping the 5' end of
a pre-mRNA b) intron removal c) RNA editing d) addition of poly(a) to the 5' end of a pre-mRNA e) all of
the above are correct examples - ANS-e) all of the the above are correct examples of common
posttranscriptional modifications of RNAs in higher Eukaryotes
The simple test used to assess mutagenicity of compounds using Salmonella auxotrophs was developed
by: - ANS-Bruce Ames
Transposable elements were first discovered by Barbara McClintock who was studying what organism? -
ANS-Zea Mays
, A human genetic disorder that results from an inability to carry out excision repair of pyrimidine dimers
is: - ANS-xeroderma pigmentosum
A human gene is found to have a number of CpG dinucleotides that are methylated at the C base. It is
very likely that this gene: - ANS-is turned off
A very strong indicator that cancer involves the mutation of multiple genes is the fact that: - ANS-The
annual incidence rate of all forms of cancer goes up with age
A group of genes that normally regulate cell cycle checkpoints and/or initiate the process of apoptosis
would be the: - ANS-signal transduction pathway encoding genes
An enhanceosome is very likely to have: - ANS-DNA-binding domain
In the context of the trp operon of E. coli, the molecule tryptophan is the: - ANS-corepressor
The single human gene whose mutation is associated most commonly with the cancerous state is: - ANS-
p53
An example of gene expression that is regulated by altering the half-life of the mRNA is: - ANS-Tubulin
expression in eukaryotes
An example of a gene or genes that are regulated by catabolite repression in yeast would be: - ANS-GAL
10 and GAL 1
A chromosome territory refers to: - ANS-A discrete domain of the nucleus occupied by a chromosome
The trp repressor binds to the region of the operon best referred to as the: - ANS-operator
Which of the following is an example of DNA binding motif? - ANS-helix-turn-helix
A process that can lead to the generation of multiple/different variants of an mRNA from a single
primary transcript is: - ANS-RNA editing (alternative splicing)
A mutation in a gene changes a codon in the expressed mRNA from UUU to UAA. Based upon your
knowledge of the genetic code and gene expression, this mutation would be BEST called a/an: - ANS-
nonsense mutation
Many/most of the genes associated with an inherited increased risk for specific forms of cancer [i.e. not
all forms of cancer] are: - ANS-tumor suppressor genes
An example of a single mutation that would likely lead directly to constitutive expression of the E. coli
trp operon would be: a) a nonsense mutation in the trpR gene b) a deletion of the trp operator region c)
a promoter mutation d) a nonsense mutation in the CAP gene e) No single mutation is likely to give
constitutive expression of this operon in E. coli - ANS-A deletion of the trp operator region constitutive =
transcribed continually Facultative = transcribed when needed
