MCB 150 UIUC Final Exam Questions
With Verified Solved Solutions.
Uses of microtubules - Answer Guiding intracellular transport, segregating chromosomes during
mitosis, propulsion or sweeping of fluids over membranes
Tubulin - Answer globular protein that makes up microtubules
a dimer, composed of two 55 kDa polypeptides (a tubulin and B tubulin)
Microtubule structure - Answer 13 linear "protofilaments" surrounding hollow core
assembled head-to-tail, has polarity
Dynamic Instability - Answer Alternating cycles of growth and shrinkage
first shown by Mitchison and Kirchner in 1984
Colchicine and Colcemid - Answer drugs that block microtubule assembly by binding tubulin
Vincristine and vinblastine - Answer drugs that selectively inhibit the microtubule assembly by binding
tubulin in rapidly dividing cells
Taxol - Answer stabilizes microtubules rather than block formation
MOC - Answer Microtubule Organizing Centers, Centrosome, located adjacent to the nucleus in
interphase cells
Centrosome - Answer MT Organizing center, in animal cells consists of a pair of centrioles surrounded
by pericentriolar material
Centrioles - Answer pair of structures made of microtubules in a "nine triplet" arrangement with
connecting proteins
, PCM - Answer Pericentriolar Material, amorphous (without shape) collection of proteins from which
the MTs emanate
Gamma Tubulin - Answer Source for new MTs, Platform for new MT dimers
Dynein - Answer Motor protein that moves towards the minus end
Kinesin - Answer Motor protein that moves towards the plus end
Axoneme - Answer Structural unit of cilia and flagella, "9+2" pattern, only has Dyneins
Basal Body - Answer Minus ends of MTs of cilia and flagella are anchored into this structure
Lamin B - Answer Stay bound to the nuclear membrane during prophase
Lamin A & C - Answer Do not stay bound to the nuclear membrane during prophase
Kinetochore - Answer place of microtubule attachment on chromosomes
Anaphase A - Answer movement of sister chromatids to opposite poles via kinetochore microtubules
Anaphase B - Answer Spindles distnace themselves from each other
Cytokinesis - Answer cytoplasmic division
Prophase - Answer Disassemble MT array, Centrosomes move to opposite poles, chromatin condenses,
nuclear envelope dissociates
With Verified Solved Solutions.
Uses of microtubules - Answer Guiding intracellular transport, segregating chromosomes during
mitosis, propulsion or sweeping of fluids over membranes
Tubulin - Answer globular protein that makes up microtubules
a dimer, composed of two 55 kDa polypeptides (a tubulin and B tubulin)
Microtubule structure - Answer 13 linear "protofilaments" surrounding hollow core
assembled head-to-tail, has polarity
Dynamic Instability - Answer Alternating cycles of growth and shrinkage
first shown by Mitchison and Kirchner in 1984
Colchicine and Colcemid - Answer drugs that block microtubule assembly by binding tubulin
Vincristine and vinblastine - Answer drugs that selectively inhibit the microtubule assembly by binding
tubulin in rapidly dividing cells
Taxol - Answer stabilizes microtubules rather than block formation
MOC - Answer Microtubule Organizing Centers, Centrosome, located adjacent to the nucleus in
interphase cells
Centrosome - Answer MT Organizing center, in animal cells consists of a pair of centrioles surrounded
by pericentriolar material
Centrioles - Answer pair of structures made of microtubules in a "nine triplet" arrangement with
connecting proteins
, PCM - Answer Pericentriolar Material, amorphous (without shape) collection of proteins from which
the MTs emanate
Gamma Tubulin - Answer Source for new MTs, Platform for new MT dimers
Dynein - Answer Motor protein that moves towards the minus end
Kinesin - Answer Motor protein that moves towards the plus end
Axoneme - Answer Structural unit of cilia and flagella, "9+2" pattern, only has Dyneins
Basal Body - Answer Minus ends of MTs of cilia and flagella are anchored into this structure
Lamin B - Answer Stay bound to the nuclear membrane during prophase
Lamin A & C - Answer Do not stay bound to the nuclear membrane during prophase
Kinetochore - Answer place of microtubule attachment on chromosomes
Anaphase A - Answer movement of sister chromatids to opposite poles via kinetochore microtubules
Anaphase B - Answer Spindles distnace themselves from each other
Cytokinesis - Answer cytoplasmic division
Prophase - Answer Disassemble MT array, Centrosomes move to opposite poles, chromatin condenses,
nuclear envelope dissociates
