NURS 474a - Pain Questions and Correct Answers/ Latest Update / Already Graded

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NURS 474a - Pain Questions and Correct
Answers/ Latest Update / Already
Graded
what enzyme do pain relievers inhibit?


Ans: cyclooxygenase (COX), an enzyme that converts arachidonic acid

into prostanoids (prostaglandins and related compounds).




Forms of cyclooxygenase


Ans: COX-1 and COX-2




cox inhibitor groups


Ans: 1. first gen NSAIDs (inhibit cox-1/2)


2. second gen NSAIDs (inhibit only cox-2)




COX 1 inhibition can cause


Ans: gastric ulceration, renal impairment, and bleeding.

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COX 2 inhibition can cause


Ans: suppresses inflammation, pain, and fever, but can also cause renal

impairment.




prototype of first gen NSAIDs


Ans: aspirin




actions of aspirn


Ans: 1. suppression of inflammation


2. relief of mild to moderate pain


3. reduction of fever


4. prevention of MI and stroke




how does aspirin work


Ans: inhibiting COX-2 and COX-1 for prevnting stroke

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aspirin


Ans: nonselective inhibitor of cox




therapeutic uses of aspirin


Ans: - analgesic


- antipyretic


- anti-inflammatory


- anti-platelet (irreversible)


- rheumatoid arthritis chronic condition




adverse effects of aspirin


Ans: Renal failure, abnormal bleeding, GI upset, drowsiness, and

confusion


SALICIYSM




aspirin - drug interactions