ASCP MLS 2025 update|comprehensive
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Terms in this set (269)
CA-125 ovarian cancer tumor marker
PSA, PAP prostate tumor marker
CA-15-3 Breast Cancer Tumor Marker
CEA colon cancer tumor marker
hsCRP increased in? AMI, inflammation
Monitors tissue damage, widely distributed
lactate dehydrogenase
throughout the body
creatine kinase Found in cardiac, brain, skeletal muscle
CK-MB Increased in AMI
CK-MM Increased in muscular disease
ALT increased in... Hepatitis
AST increased in... Hepatitis
Alkaline phosphatase Hepatitis and bone disorders (found in hepatobiliary
increased in... and bone)
GGT increased in... Recent alcohol use, liver disorders
Amylase increased in... Pancreatitis, not very specific
Lipase increased in... Pancreatitis, more specific, but rises slower
Apolipoproteins Proton component free from lipid
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Friedewald Calculation is Calculating LDL
for...
Friedewald calculation (Total chol) - (HDL chol)-(Trig/5)
Insulin released when? Increased blood glucose
Glucagon released Decreased blood glucose
when?
Glycogenolysis breakdown of glycogen to glucose
Glycolysis Breakdown of glucose
Insulin does what in the Decrease glycogenolysis and glycolysis, increase
body? glucose uptake by cells
Glucagon does what in Increase glycogenolysis, signals liver to breakdown
the body? glucose and fat
Glucose produced Produced in liver
where?
Hemoglobin is broken CO, Globin, Iron, Bilirubin
down into... (4)
Unconjugated bilirubin Indirect, insoluble, bound to albumin
conjugated bilirubin Direct, bound to water soluble molecule
What type of bilirubin is Unconjugated bilirubin
found in urine?
Even more water soluble and easy to excrete than
Urobilinogen
conj. Bilirubin
Increased bilirubin production due to hemolysis or
prehepatic jaundice
ineffective erythropoiesis
Abnormal bilirubin metabolism (e.g. cell damage,
hepatic jaundice
hepatitis)
Decreased bilirubin excretion, usually caused by
Post-hepatic jaundice
obstruction
Test results in PRE Increased indirect serum bilirubin, stool and urine
hepatic jaundice urobilinogen. Normal direct serum bilirubin.
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Proteins, in order of most Prealbumin, albumin, alpha 1, alpha 2, beta, gamma
anodic to least anodic
Albumin decreased in... Inflammation and protein loss
Ceruloplasmin transports copper
Transferrin transports iron
IgG, IgM and IgA: In inflammation and in monoclonal spikes in
increased in protein myeloma
electrophoresis when...
Test results in Increased total protein, increased albumin,
dehydration increased Serum Na, Increased Osmo
proteinuria is associated Disease of the kidney, such as glomerular nephritis
with...
Increased total protein in serum, decr. albumin, decr.
Test results in multiple
albumin:globulin ratio, prescience of monoclonal
myeloma
paraproteins
Disease of the kidneys caused by damage to the
Nephropathy
small blood vessels
Non-protein nitrogenous Come from breakdown of protein and nucleic acid
substances
Indicates overall kidney function; increased
Urea
BUN/Creat Ratio in dehydration
Creatinine indicates... Glomerular function
Increased plasma creat Early nephropathy
and clearance in...
Decreased creat Renal failure
clearance in...
Liver function (increased in liver failure and Reye's
Ammonia indicates...
syndrome)
Creat Cleance (Urine creat) X (volume in mL/min) (surface area,
Calculation 1.73) all divided by serum creat
Corticosteroid hormone that stimulates kidney to
Aldosterone
absorb Na to regulate salt and water balance
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