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MLS Hematology Exam Questions And
Answers |Latest 2025 | Guaranteed Pass.
What is the first type of cell produced by the developing embryo? - Answer✔Erythrocyte
What percentage of tissue located in the bone marrow cavities of adults is fat? - Answer✔50%
Which of the following is not characteristic of pluripotent hematopoietic stem cells? -
Answer✔Express the stem marker CD13
In an adult, what are the two best areas for obtaining active bone marrow by aspiration? -
Answer✔Posterior iliac crest, sternum
What is the normal ratio of myeloid to erythroid precursors in bone marrow (M:E ratio)? -
Answer✔4:1
Which of the following does not accurately describe hematopoietic growth factors? -
Answer✔Action of majority is lineage restricted
In the third month of gestation, what is the primary site of hematopoiesis? - Answer✔Liver
The mechanism that relays information about tissue oxygen levels to erythropoietin-producing
sites is located in the: - Answer✔Kidney
Antigen-independent lymphopoiesis occurs in primary lymphoid tissue located in the: -
Answer✔Thymus and bone marrow
Programmed cell death is called: - Answer✔Apoptosis
In what area of the bone marrow does hematopoiesis take place? - Answer✔Cords
Bone marrow cellularity refers to the ration of: - Answer✔Hematopoietic tissue to adipose
tissue
Interleukins and colony stimulating factors are cytokines produced by: - Answer✔Monocytes
and T lymphocytes
What is the approximate total blood volume in an adult? - Answer✔6 L
1
, ©THESTAR 2024/2025 ALL RIGHTS RESERVED 3:09PM.
The myeloid progenitor cell can produce cells committed to: - Answer✔Granulocytic,
erythrocytic, monocytic, or megakaryocytic lineages
The largest hematopoietic cells in normal bone marrow are: - Answer✔Megakaryocytes
When evaluating a bone marrow aspirate smear, which finding is considered abnormal? -
Answer✔The presence of 10% myeloblasts on the cell differential count
As most blood cell lines mature, which of the following is characteristic? - Answer✔Nucleus to
cytoplasm ratio (N:C) decreases
Which of the following describes thrombopoietin (TPO)? - Answer✔Hormone produced by the
liver that stimulates megakaryopoiesis
When the hepatic phase of fetal life is reactivated in an adult, hematopoiesis can be termed: -
Answer✔Myeloid metaplasia or extramedullary
What is the average life span of a normal red blood cell? - Answer✔120 days
The Na+-K+ cation pump is an important mechanism in keeping the red blood cell intact. Its
function is to maintain a high level of: - Answer✔Intracellular K+
Which of the following depicts the structure of the hemoglobin molecule? - Answer✔Four
heme groups, four globin chains
Which of the following describes the process known as culling? - Answer✔Removal of abnormal
red cells by spleen
Hemoglobin forms that are incapable of oxygen transport include: -
Answer✔Carboxyhemoglobin and methemoglobin
The majority of iron found in an adult is a constituent of: - Answer✔Hemoglobin
A senescent red blood cell is one that has: - Answer✔Lived its life span
What red cell morphologic abnormality is described by the term "poikilocytosis"? -
Answer✔Deviations from normal shape
Howell-Jolly bodies are composed of: - Answer✔DNA
When spherocytes are reported, what is observed on the peripheral blood smear? -
Answer✔Red cells without a central pallor
The red cells found in lead poisoning characteristically exhibit coarse granules composed of
__________ that are reported as _________. - Answer✔Aggregated ribosomes; basophilic
stippling
2
, ©THESTAR 2024/2025 ALL RIGHTS RESERVED 3:09PM.
Rouleaux of red blood cells when seen in the monolayer of a blood smear is characteristic of: -
Answer✔Multiple myeloma
Which of the following is most frequently associated with the inclusion bodies seen in Color
Plate 1? - Answer✔Post-splenectomy
Which of the following statements about iron absorption is true? - Answer✔Absorption
increases when erythropoietic activity increases
What term describes a mature red blood cell that contains iron granules or deposits? -
Answer✔Siderocyte
Which of the following is associated with a "shift to the left" in the oxygen dissociation curve of
hemoglobin? - Answer✔Decreased oxygen release
Which of the following statements does not characterize erythropoietin (EPO)? -
Answer✔Decreases stimulation of erythropoiesis when cellular hypoxia increases
Which of the following factors will result in an immediate increase in oxygen delivery to the
tissues? - Answer✔Increased hemoglobin binding of 2,3-BPG
Periods of intense erythropoietin activity cause premature release of marrow reticulocytes into
the blood. Which of the following is not true of these early reticulocytes? - Answer✔Loss of
residual RNA occurs immediately upon marrow release
Which of the following inclusions is only visible with supravital staining? - Answer✔Heinz bodies
The presence of schistocytes on the peripheral blood smear is commonly associated with: -
Answer✔Increased red cell destruction
Which of the following may be a sign of accelerated bone marrow erythropoiesis? -
Answer✔Nucleated red cells in the peripheral circulation
Microcytic, hypochromic red cells are most often associated with impaired: -
Answer✔Hemoglobin synthesis
When in bone marrow, nucleated red cells present would be staged as: -
Answer✔Orthochromic normoblasts
When acanthocytes are found on the blood smear, it is usually the result of: - Answer✔Altered
membrane lipids
Which erythrocyte metabolic pathway generates adenosine triphosphate (ATP) via glycolysis? -
Answer✔Embden-Meyerhof
3
MLS Hematology Exam Questions And
Answers |Latest 2025 | Guaranteed Pass.
What is the first type of cell produced by the developing embryo? - Answer✔Erythrocyte
What percentage of tissue located in the bone marrow cavities of adults is fat? - Answer✔50%
Which of the following is not characteristic of pluripotent hematopoietic stem cells? -
Answer✔Express the stem marker CD13
In an adult, what are the two best areas for obtaining active bone marrow by aspiration? -
Answer✔Posterior iliac crest, sternum
What is the normal ratio of myeloid to erythroid precursors in bone marrow (M:E ratio)? -
Answer✔4:1
Which of the following does not accurately describe hematopoietic growth factors? -
Answer✔Action of majority is lineage restricted
In the third month of gestation, what is the primary site of hematopoiesis? - Answer✔Liver
The mechanism that relays information about tissue oxygen levels to erythropoietin-producing
sites is located in the: - Answer✔Kidney
Antigen-independent lymphopoiesis occurs in primary lymphoid tissue located in the: -
Answer✔Thymus and bone marrow
Programmed cell death is called: - Answer✔Apoptosis
In what area of the bone marrow does hematopoiesis take place? - Answer✔Cords
Bone marrow cellularity refers to the ration of: - Answer✔Hematopoietic tissue to adipose
tissue
Interleukins and colony stimulating factors are cytokines produced by: - Answer✔Monocytes
and T lymphocytes
What is the approximate total blood volume in an adult? - Answer✔6 L
1
, ©THESTAR 2024/2025 ALL RIGHTS RESERVED 3:09PM.
The myeloid progenitor cell can produce cells committed to: - Answer✔Granulocytic,
erythrocytic, monocytic, or megakaryocytic lineages
The largest hematopoietic cells in normal bone marrow are: - Answer✔Megakaryocytes
When evaluating a bone marrow aspirate smear, which finding is considered abnormal? -
Answer✔The presence of 10% myeloblasts on the cell differential count
As most blood cell lines mature, which of the following is characteristic? - Answer✔Nucleus to
cytoplasm ratio (N:C) decreases
Which of the following describes thrombopoietin (TPO)? - Answer✔Hormone produced by the
liver that stimulates megakaryopoiesis
When the hepatic phase of fetal life is reactivated in an adult, hematopoiesis can be termed: -
Answer✔Myeloid metaplasia or extramedullary
What is the average life span of a normal red blood cell? - Answer✔120 days
The Na+-K+ cation pump is an important mechanism in keeping the red blood cell intact. Its
function is to maintain a high level of: - Answer✔Intracellular K+
Which of the following depicts the structure of the hemoglobin molecule? - Answer✔Four
heme groups, four globin chains
Which of the following describes the process known as culling? - Answer✔Removal of abnormal
red cells by spleen
Hemoglobin forms that are incapable of oxygen transport include: -
Answer✔Carboxyhemoglobin and methemoglobin
The majority of iron found in an adult is a constituent of: - Answer✔Hemoglobin
A senescent red blood cell is one that has: - Answer✔Lived its life span
What red cell morphologic abnormality is described by the term "poikilocytosis"? -
Answer✔Deviations from normal shape
Howell-Jolly bodies are composed of: - Answer✔DNA
When spherocytes are reported, what is observed on the peripheral blood smear? -
Answer✔Red cells without a central pallor
The red cells found in lead poisoning characteristically exhibit coarse granules composed of
__________ that are reported as _________. - Answer✔Aggregated ribosomes; basophilic
stippling
2
, ©THESTAR 2024/2025 ALL RIGHTS RESERVED 3:09PM.
Rouleaux of red blood cells when seen in the monolayer of a blood smear is characteristic of: -
Answer✔Multiple myeloma
Which of the following is most frequently associated with the inclusion bodies seen in Color
Plate 1? - Answer✔Post-splenectomy
Which of the following statements about iron absorption is true? - Answer✔Absorption
increases when erythropoietic activity increases
What term describes a mature red blood cell that contains iron granules or deposits? -
Answer✔Siderocyte
Which of the following is associated with a "shift to the left" in the oxygen dissociation curve of
hemoglobin? - Answer✔Decreased oxygen release
Which of the following statements does not characterize erythropoietin (EPO)? -
Answer✔Decreases stimulation of erythropoiesis when cellular hypoxia increases
Which of the following factors will result in an immediate increase in oxygen delivery to the
tissues? - Answer✔Increased hemoglobin binding of 2,3-BPG
Periods of intense erythropoietin activity cause premature release of marrow reticulocytes into
the blood. Which of the following is not true of these early reticulocytes? - Answer✔Loss of
residual RNA occurs immediately upon marrow release
Which of the following inclusions is only visible with supravital staining? - Answer✔Heinz bodies
The presence of schistocytes on the peripheral blood smear is commonly associated with: -
Answer✔Increased red cell destruction
Which of the following may be a sign of accelerated bone marrow erythropoiesis? -
Answer✔Nucleated red cells in the peripheral circulation
Microcytic, hypochromic red cells are most often associated with impaired: -
Answer✔Hemoglobin synthesis
When in bone marrow, nucleated red cells present would be staged as: -
Answer✔Orthochromic normoblasts
When acanthocytes are found on the blood smear, it is usually the result of: - Answer✔Altered
membrane lipids
Which erythrocyte metabolic pathway generates adenosine triphosphate (ATP) via glycolysis? -
Answer✔Embden-Meyerhof
3
