PM 243 PCOS EXAM QUESTIONS AND
ANSWERS
Amadori rearrangement - ANSWER-N-glycoside of an aldose or glycosylamine to
corresponding 1-amino-1-deoxy-ketose
receptors for advanced glycation end products (RAGE) - ANSWER-transmembrane
protein expressed in several tissues
engagement by its substrate activates the substract/receptor pathway of (xxx)?
MECA79 - ANSWER-antibody recognizes 6-sulfo sLex -a sulfate and carbohydrate
epitope dependent on GlcNAc
L-selectin ligands
HECA435 - ANSWER-antibody reacting w/ sLex requiring sialisation and fucosilation for
epitope recognition
Expression of GlcNAc6ST-2 in HEV in lymph nodes is essential for elaboration of
selectin ligands and generation of MECA79 epitope
L-selectin ligands
fertile > PCOS endometria - ANSWER-Epithelial MECA79 staining
PCOS > fertile endometria - ANSWER-Epithelial HECA452 staining
GlcNAc6ST-2 (N-acetylglucosamine-6-O-sulfotransferase) - ANSWER-Enz for
HECA452 to MECA79
MUC1 - ANSWER-first molecule the embryo encounters in route to attachment
glycoprotein that presents MECA79 epitopes
continuously produced in epithelial endometrial cells during the receptive period
Repels embryo directing it towards the implantation site rich in pinopods
National institute for health criteria - ANSWER-Diagnostic criteria
hyperandrogenism, menstrual irregularity
Rotterdam criteria - ANSWER-Diagnostic criteria
hyperandrogenism, menstrual irregularity, polycystic ovaries on ultrasonography
Androgen excess PCOS society criteria - ANSWER-Diagnostic criteria
hyperandrogenism, menstrual irregularity or polycystic ovaries on ultrasonography
Hyperandrogenism - ANSWER-o Clinical examination - hirsutism, acne, androgenic
alopecia, acanthosis nigricans
o Laboratory values - high circulating levels of testosterone or androstenedione
ANSWERS
Amadori rearrangement - ANSWER-N-glycoside of an aldose or glycosylamine to
corresponding 1-amino-1-deoxy-ketose
receptors for advanced glycation end products (RAGE) - ANSWER-transmembrane
protein expressed in several tissues
engagement by its substrate activates the substract/receptor pathway of (xxx)?
MECA79 - ANSWER-antibody recognizes 6-sulfo sLex -a sulfate and carbohydrate
epitope dependent on GlcNAc
L-selectin ligands
HECA435 - ANSWER-antibody reacting w/ sLex requiring sialisation and fucosilation for
epitope recognition
Expression of GlcNAc6ST-2 in HEV in lymph nodes is essential for elaboration of
selectin ligands and generation of MECA79 epitope
L-selectin ligands
fertile > PCOS endometria - ANSWER-Epithelial MECA79 staining
PCOS > fertile endometria - ANSWER-Epithelial HECA452 staining
GlcNAc6ST-2 (N-acetylglucosamine-6-O-sulfotransferase) - ANSWER-Enz for
HECA452 to MECA79
MUC1 - ANSWER-first molecule the embryo encounters in route to attachment
glycoprotein that presents MECA79 epitopes
continuously produced in epithelial endometrial cells during the receptive period
Repels embryo directing it towards the implantation site rich in pinopods
National institute for health criteria - ANSWER-Diagnostic criteria
hyperandrogenism, menstrual irregularity
Rotterdam criteria - ANSWER-Diagnostic criteria
hyperandrogenism, menstrual irregularity, polycystic ovaries on ultrasonography
Androgen excess PCOS society criteria - ANSWER-Diagnostic criteria
hyperandrogenism, menstrual irregularity or polycystic ovaries on ultrasonography
Hyperandrogenism - ANSWER-o Clinical examination - hirsutism, acne, androgenic
alopecia, acanthosis nigricans
o Laboratory values - high circulating levels of testosterone or androstenedione
