Harr, Immunohematology UPDATED
ACTUAL Questions and CORRECT
Answers
what type of serological testing does the blood bank tech perform when determining the blood
group of a patient? - CORRECT ANSWER - phenotyping
if anti-K reacts 3+ with a donor cell with a genotype KK and 2+ with a Kk cell, the antibody is
demonstrating: - CORRECT ANSWER - dosage
carla expresses the blood group antigens Fya, Fyb, and Xga. James shows expressions of none of
these antigens. What factor may account for the absence of these antigens in James? -
CORRECT ANSWER - gender and race
An individual with the BB genotype is homozygous for which antigen? - CORRECT
ANSWER -B
which genotype is heterozygous for C? - CORRECT ANSWER - DCe/dce
which genotype will give rise to the bombay phenotype? - CORRECT ANSWER - bb only
Meiosis in cell division is limited to the ova and sperm producing four gametes containing what
complement of DNA? - CORRECT ANSWER - 1N
A cell that is not actively dividing is said to be in: - CORRECT ANSWER - interphase
which of the following describes the expression of most blood group antigens? - CORRECT
ANSWER - codominant
,what blood type is not possible for emerging offspring of an AO and BO mating? - CORRECT
ANSWER - AB, A or B, O (all)
the alleged father of a child in a disputed case of paternity is blood group AB. the mother is
group O and the child is group O. what type of exclusion is this? - CORRECT ANSWER -
indirect/secondary/second order
if the frequency of gene Y is .4 and the frequency of gene Z is .5, one would expect that they
should occur together .2 of the time. in actuality, they are found together .32 of the time. this is
an example of: - CORRECT ANSWER - linkage diseqilibrium
in the hardy-weinberg formula, p2 represents: - CORRECT ANSWER - the homo
population of one allelle
in this type of inheritance, the father carries the trait on his x chromosome. he has no sons with
the trait because he passed his Y chromosome to his sons, however, all his daughters will express
the trait - CORRECT ANSWER - X linked dominant
why do IgM antibodies, such as those formed against the ABO antigens, have the ability to
directly agglutinate RBC and cause visible agglutination? - CORRECT ANSWER - IgM
antibodies are larger molecules and have the ability to bind more antigen
which of the following enhancement mediums decreases the zeta potential, allowing antibody
and antigen to come closer together? - CORRECT ANSWER - LISS
this type of antibody response is analogous to an anamnestic antibody reaction. - CORRECT
ANSWER - secondary
thich antibodies to a component of complement are contained in the rabbit polyspecific
antihuman globulin reagent for detection of in vivo sensitization? - CORRECT
ANSWER - anti IgG and anti-C3d
, which of the following distinguishes A1 from A2 blood groups? - CORRECT ANSWER -
an A2 person may form anti-A1, an A1 person will not form anti A1
a patients serum is incompatible with O cells. the patient RBC give a negative reaction to anti-H
lectin. WHat is the most likely cause of these results? - CORRECT ANSWER - the patient
may be bombay
what antiodies are formed by a bombay individual? - CORRECT ANSWER - anti A, B,
and H
acquired B antigens have been found in: - CORRECT ANSWER - group A persons
blood is crossmatched on an A pos person with a negative antibody screen. the patient received a
transfusion of A pos RBC 3 years ago. the donors chosen for crossmatch were A pos. the
crossmatch was run on the ortho provue and yielded 3+ incompatibility. how can these results be
explained? - CORRECT ANSWER - the patient is an A2 with an anti A1
a patients red cells forward as a group O, serum agglutinates B cells only. Your next step would
be: - CORRECT ANSWER - incubate washed red cells with anti-A1 and and anti-A,B for
30 minutes at room temp
which typing results are most likely to occur when a patient has an acquired B antigen? -
CORRECT ANSWER - anti A 4+, anti B 1+, A1 neg, B cells 4+
which blood group has the least amount of H antigen? - CORRECT ANSWER - A1B
what type RBC can be transfused into an A2 person with anti-A1? - CORRECT
ANSWER - A or O
what should be done if all forward and reverse ABO results as well as the autocontrol are
positive? - CORRECT ANSWER - wash the cells with warm saline, autoadsorb the serum
at 4 degrees
ACTUAL Questions and CORRECT
Answers
what type of serological testing does the blood bank tech perform when determining the blood
group of a patient? - CORRECT ANSWER - phenotyping
if anti-K reacts 3+ with a donor cell with a genotype KK and 2+ with a Kk cell, the antibody is
demonstrating: - CORRECT ANSWER - dosage
carla expresses the blood group antigens Fya, Fyb, and Xga. James shows expressions of none of
these antigens. What factor may account for the absence of these antigens in James? -
CORRECT ANSWER - gender and race
An individual with the BB genotype is homozygous for which antigen? - CORRECT
ANSWER -B
which genotype is heterozygous for C? - CORRECT ANSWER - DCe/dce
which genotype will give rise to the bombay phenotype? - CORRECT ANSWER - bb only
Meiosis in cell division is limited to the ova and sperm producing four gametes containing what
complement of DNA? - CORRECT ANSWER - 1N
A cell that is not actively dividing is said to be in: - CORRECT ANSWER - interphase
which of the following describes the expression of most blood group antigens? - CORRECT
ANSWER - codominant
,what blood type is not possible for emerging offspring of an AO and BO mating? - CORRECT
ANSWER - AB, A or B, O (all)
the alleged father of a child in a disputed case of paternity is blood group AB. the mother is
group O and the child is group O. what type of exclusion is this? - CORRECT ANSWER -
indirect/secondary/second order
if the frequency of gene Y is .4 and the frequency of gene Z is .5, one would expect that they
should occur together .2 of the time. in actuality, they are found together .32 of the time. this is
an example of: - CORRECT ANSWER - linkage diseqilibrium
in the hardy-weinberg formula, p2 represents: - CORRECT ANSWER - the homo
population of one allelle
in this type of inheritance, the father carries the trait on his x chromosome. he has no sons with
the trait because he passed his Y chromosome to his sons, however, all his daughters will express
the trait - CORRECT ANSWER - X linked dominant
why do IgM antibodies, such as those formed against the ABO antigens, have the ability to
directly agglutinate RBC and cause visible agglutination? - CORRECT ANSWER - IgM
antibodies are larger molecules and have the ability to bind more antigen
which of the following enhancement mediums decreases the zeta potential, allowing antibody
and antigen to come closer together? - CORRECT ANSWER - LISS
this type of antibody response is analogous to an anamnestic antibody reaction. - CORRECT
ANSWER - secondary
thich antibodies to a component of complement are contained in the rabbit polyspecific
antihuman globulin reagent for detection of in vivo sensitization? - CORRECT
ANSWER - anti IgG and anti-C3d
, which of the following distinguishes A1 from A2 blood groups? - CORRECT ANSWER -
an A2 person may form anti-A1, an A1 person will not form anti A1
a patients serum is incompatible with O cells. the patient RBC give a negative reaction to anti-H
lectin. WHat is the most likely cause of these results? - CORRECT ANSWER - the patient
may be bombay
what antiodies are formed by a bombay individual? - CORRECT ANSWER - anti A, B,
and H
acquired B antigens have been found in: - CORRECT ANSWER - group A persons
blood is crossmatched on an A pos person with a negative antibody screen. the patient received a
transfusion of A pos RBC 3 years ago. the donors chosen for crossmatch were A pos. the
crossmatch was run on the ortho provue and yielded 3+ incompatibility. how can these results be
explained? - CORRECT ANSWER - the patient is an A2 with an anti A1
a patients red cells forward as a group O, serum agglutinates B cells only. Your next step would
be: - CORRECT ANSWER - incubate washed red cells with anti-A1 and and anti-A,B for
30 minutes at room temp
which typing results are most likely to occur when a patient has an acquired B antigen? -
CORRECT ANSWER - anti A 4+, anti B 1+, A1 neg, B cells 4+
which blood group has the least amount of H antigen? - CORRECT ANSWER - A1B
what type RBC can be transfused into an A2 person with anti-A1? - CORRECT
ANSWER - A or O
what should be done if all forward and reverse ABO results as well as the autocontrol are
positive? - CORRECT ANSWER - wash the cells with warm saline, autoadsorb the serum
at 4 degrees
