PACOP PINK – Pharmacology UPDATED
ACTUAL Exam Questions and CORRECT
Answers
B - CORRECT ANSWER - 1. Two dose-response curve response plotted on the same
graph showed sigmoid curves having the same
slope and height. T curve is located to the right of the A curve. Which of the following statements
is/are
correct regarding curves A an:
I. A is more effective than B
II. A is more potent than B
III. A and B have the same ceiling dose
IV. B is the graph produced when A is given with its competitive antagonist
V. B is the graph produced when A is given with its non-competitive antagonist
a. Only I and III are correct
b. Only II, III and IV are correct
c. Only II and IV are correct
d. Only III and V are correct
e. Only V is correct
D - CORRECT ANSWER - 2. Two dose-response curve plotted on the same graph showed
sigmoid curves A and B, where A is at the left
of the graph with the height greater than B. Which of the following statements is/are correct
regarding
curves A and B?
I. A and B has equal efficacy
II. A and B have equal potency
III. B is a partial agonist of A
IV. B is the graph produced when A is given with its competitive antagonist
,V. B is the graph produced when A is given with its non-competitive antagonist
a. Only I and III are correct
b. Only II, III and IV are correct
c. Only II and IV are correct
d. Only III and V are correct
e. Only V is correct
E - CORRECT ANSWER - 3. The cumulative number of subjects who display a certain
response or effect to a drug is plotted on a graph
as shown below. The graph on the left represents beneficial effect while the graph on the right
represents
toxic effect, what is the therapeutic index of the drug?
a.0.5 b. 1.5 c. 2.5 d.4.0 e. 5.0
E - CORRECT ANSWER - 4. An administration of one drug leads to a shift in the log
dose-response curve of another drug to the left a
range in the maximal efficacy, this is called
a. Agonism
b. Partial agonism
c. Non-competitive antagonism
d. Competitive antagonism
e. Potentiation
A - CORRECT ANSWER - 5. The action of this drug is dependent on a colligative
property
a. Mannitol
b. Cocaine
c. Reserpine
d. Furosemide
,e. Losartan
D - CORRECT ANSWER - 6. Which of the following drug groups have mechanisms of
action that involve binding to enzymes as target proteins
a. Benzodiazepines
b. Barbiturates
c. Calcium channel blockers
d. Non-steroidal anti-inflammatory agents
e. Phenothiazine antipsychotics
B - CORRECT ANSWER - 7. Voltage-gated ion channels serve as site of actions for drugs
such as
I. Diltiazem and Nifedipine
II. Lidocaine and Procaine
III. Captopril and Losartan
a. I only
b. I and II
c. III only
d. I and III
e. I, II, and III
C - CORRECT ANSWER - 8. Drugs with mechanism of action that involves Tubulin-
binding leading to loss of function of the structural
protein include
a. Cyclosporine
b. Neostigmine
c. Colchicine
d. Glibenclamide
e. Metformin
, D - CORRECT ANSWER - 9. What type of protein is primarily targeted by Digitalis
glycosides when they exert their effect on the heart?
a. Receptors
b. Ion channels
c. Enzymes
d. Transporters
e. Structural proteins
A - CORRECT ANSWER - 10. Which of the following features characterize nicotinic,
GABA-A, and Glutamate receptors?
a. They control the movements of ions and out of the cell
b. Their action is mediated by secondary messengers
c. They all have excitatory effect on the cell membrane
d. They are located on the cytoplasm
D - CORRECT ANSWER - 11. Which of the following drugs bind to receptors located at
the cell membrane?
a. Thyroid hormone
b. Prednisone
c. Estrogen
d. Insulin
e. Vitamin D
C - CORRECT ANSWER - 12. Cyclic Adenosine Monophophate (cAMP) is generated as
a secondary messenger by the action of the
enzyme Adenylyl Cyclase. The substrate for the synthesis of cAMP is
a. AMD
b. ADP
ACTUAL Exam Questions and CORRECT
Answers
B - CORRECT ANSWER - 1. Two dose-response curve response plotted on the same
graph showed sigmoid curves having the same
slope and height. T curve is located to the right of the A curve. Which of the following statements
is/are
correct regarding curves A an:
I. A is more effective than B
II. A is more potent than B
III. A and B have the same ceiling dose
IV. B is the graph produced when A is given with its competitive antagonist
V. B is the graph produced when A is given with its non-competitive antagonist
a. Only I and III are correct
b. Only II, III and IV are correct
c. Only II and IV are correct
d. Only III and V are correct
e. Only V is correct
D - CORRECT ANSWER - 2. Two dose-response curve plotted on the same graph showed
sigmoid curves A and B, where A is at the left
of the graph with the height greater than B. Which of the following statements is/are correct
regarding
curves A and B?
I. A and B has equal efficacy
II. A and B have equal potency
III. B is a partial agonist of A
IV. B is the graph produced when A is given with its competitive antagonist
,V. B is the graph produced when A is given with its non-competitive antagonist
a. Only I and III are correct
b. Only II, III and IV are correct
c. Only II and IV are correct
d. Only III and V are correct
e. Only V is correct
E - CORRECT ANSWER - 3. The cumulative number of subjects who display a certain
response or effect to a drug is plotted on a graph
as shown below. The graph on the left represents beneficial effect while the graph on the right
represents
toxic effect, what is the therapeutic index of the drug?
a.0.5 b. 1.5 c. 2.5 d.4.0 e. 5.0
E - CORRECT ANSWER - 4. An administration of one drug leads to a shift in the log
dose-response curve of another drug to the left a
range in the maximal efficacy, this is called
a. Agonism
b. Partial agonism
c. Non-competitive antagonism
d. Competitive antagonism
e. Potentiation
A - CORRECT ANSWER - 5. The action of this drug is dependent on a colligative
property
a. Mannitol
b. Cocaine
c. Reserpine
d. Furosemide
,e. Losartan
D - CORRECT ANSWER - 6. Which of the following drug groups have mechanisms of
action that involve binding to enzymes as target proteins
a. Benzodiazepines
b. Barbiturates
c. Calcium channel blockers
d. Non-steroidal anti-inflammatory agents
e. Phenothiazine antipsychotics
B - CORRECT ANSWER - 7. Voltage-gated ion channels serve as site of actions for drugs
such as
I. Diltiazem and Nifedipine
II. Lidocaine and Procaine
III. Captopril and Losartan
a. I only
b. I and II
c. III only
d. I and III
e. I, II, and III
C - CORRECT ANSWER - 8. Drugs with mechanism of action that involves Tubulin-
binding leading to loss of function of the structural
protein include
a. Cyclosporine
b. Neostigmine
c. Colchicine
d. Glibenclamide
e. Metformin
, D - CORRECT ANSWER - 9. What type of protein is primarily targeted by Digitalis
glycosides when they exert their effect on the heart?
a. Receptors
b. Ion channels
c. Enzymes
d. Transporters
e. Structural proteins
A - CORRECT ANSWER - 10. Which of the following features characterize nicotinic,
GABA-A, and Glutamate receptors?
a. They control the movements of ions and out of the cell
b. Their action is mediated by secondary messengers
c. They all have excitatory effect on the cell membrane
d. They are located on the cytoplasm
D - CORRECT ANSWER - 11. Which of the following drugs bind to receptors located at
the cell membrane?
a. Thyroid hormone
b. Prednisone
c. Estrogen
d. Insulin
e. Vitamin D
C - CORRECT ANSWER - 12. Cyclic Adenosine Monophophate (cAMP) is generated as
a secondary messenger by the action of the
enzyme Adenylyl Cyclase. The substrate for the synthesis of cAMP is
a. AMD
b. ADP
