BPS 319 - Lecture 5 Passage Of Routes
Through Membranes 1 QUESTIONS WITH
CORRECT ANSWERS
absorption from GI tract or other site of drug application
distribution important for drug to get to its site of action - must pass through membrane of
capillary and tissue
metabolism drug must get into hepatocyte for metabolism in liver
excretion drug must go through glomerular membrane in kidney
drugs acting within a cell penetrates cell membranes
passive diffusion most important method of membrane passage and movement of drug
around the body
passive diffusion the movement of molecules from an area of high concentration to low
concentration
free, unbound drugs What are the only kinds of drugs that can participate in passive
diffusion?
, Concentration gradient
Permeability of drug through membrane
Lipophilicity
pH and pKa
Surface area of the membrane What factors can affect diffusion?
more The larger surface area, the _____ drug is able to pass through
less The smaller surface area, the _____ drug is able to pass through
Fick's law equation dAb/dt = kCu1
Pm the permeability of drug through membrane or ease with which drug passes through
-function of drug and membrane
SAm the surface area of the membrane
True T or F: The drug has to be in solution to participate in the concentration gradient and
pass through the membrane
1st order Is diffusion a 1st or 2nd order process?
Through Membranes 1 QUESTIONS WITH
CORRECT ANSWERS
absorption from GI tract or other site of drug application
distribution important for drug to get to its site of action - must pass through membrane of
capillary and tissue
metabolism drug must get into hepatocyte for metabolism in liver
excretion drug must go through glomerular membrane in kidney
drugs acting within a cell penetrates cell membranes
passive diffusion most important method of membrane passage and movement of drug
around the body
passive diffusion the movement of molecules from an area of high concentration to low
concentration
free, unbound drugs What are the only kinds of drugs that can participate in passive
diffusion?
, Concentration gradient
Permeability of drug through membrane
Lipophilicity
pH and pKa
Surface area of the membrane What factors can affect diffusion?
more The larger surface area, the _____ drug is able to pass through
less The smaller surface area, the _____ drug is able to pass through
Fick's law equation dAb/dt = kCu1
Pm the permeability of drug through membrane or ease with which drug passes through
-function of drug and membrane
SAm the surface area of the membrane
True T or F: The drug has to be in solution to participate in the concentration gradient and
pass through the membrane
1st order Is diffusion a 1st or 2nd order process?
