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What is the etiology, incubation, and mode of transmission for
measles -<<,Answers>>>Initial infection and viral replication
occur locally in tracheal and bronchial epithelial cells. After
2-4 days, local lymphatic tissues are infected. Virus is
disseminated to various organs, and rash appears.
Transmitted by respiratory droplets, either airborne or on
surfaces up to 2 hours
Incubated 7-14 days (average 10-12 days)
discuss hemophilia A -<<,Answers>>>affects 1 in 5-10K
males
sex linked recessive disease, deficient in factor VIII
normal platelets and PT, prolonged PTT, decreased factor
VIII
CM: knee, elbow, and ankle bleeds, GI bleeds
discuss hemophilia B -<<,Answers>>>affects 1 in 20-30K
males
Christmas disease- deficient in factor IX
normal platelets and PT, prolonged PTT, decreased factor IX
CM: knee, elbow, and ankle bleeds, GI bleeds
,discuss DIC -<<,Answers>>>activation of the coagulation
system causes widespread intravascular fibrin deposition,
fibrinolytic products attempt to break down fibrin- adhere to
platelets to prevent adhesion. coagulation products are
eventually consumed and bleeding occurs. may cause organ
failure r/t micro-thrombi
triggers: malignancy, sepsis, infection, ob complications,
trauma, Sx, ARDS, rhabdo, venomous snake bites
CM: oozing, bleeding from all puncture sites, bleeds from all
body cavities, prolonged PT/PTT, elevated d-dimer, platelet
count <100,000
discuss Vitamin K deficiency -<<,Answers>>>CM: easy
bruising, oozing from nose or gums, excessive wound
bleeding, menorrhagia
discuss liver disease -<<,Answers>>>all factors of clotting
can be affected
Hageman deficiency -<<,Answers>>>deficiency of factor
XII- rare genetic disorder
asymptomatic, causes prolonged clotting test with no clinical
bleeding or risk present
, causes of thrombus -<<,Answers>>>Triad of Virchow- injury
to blood vessels, abnormality in blood flow,
hypercoagulability
some medications increase risks
discuss macrocytic, microcytic, and normocytic anemias -
<<,Answers>>>classified by size of RBC
macrolytic- MCV >100, includes pernicious and folic acid
anemias, can be caused by ETOH
microlytic- MCV <80, folic acid anemia
normolytic- MCV 80-100 (normal range), sickle cell is an
example
Pathophysiology and clinical implications of pernicious
anemia -<<,Answers>>>A Vitamin B12 deficient leads to
fewer RBCs- intrinsic factor is lacking- RBCs get big, but not
mature
Macrocytic
Typical at age 60 as 10 years of B12 is stored in body
Risk factors and CM of pernicious anemia -
<<,Answers>>>Risk: vegan, gastrectomy, atrophy of gastric
mucosa r/t autoimmune disease
CM: beefy red tongue, weakness, fatigue, loss of appetite,
weight loss, neurological symptoms- parenthesis of
hands/feet, loss of sense of position and vibration