NR 565 - ADVANCED PHARMACOLOGY MIDTERM – CHAMBERLAIN QUESTIONS WITH CORRECT ANSWERS 2025

NR 565 - ADVANCED PHARMACOLOGY
MIDTERM – CHAMBERLAIN QUESTIONS
WITH CORRECT ANSWERS 2025
DuringRwhatRtrimesterRisRaRpregnantRwomanRmostRatRriskRforRadverseRdrugRreactionsRwithRpotentialRlongRt
ermRconsequences?R-RCORRECTRANSWERR-1stRtrimesterR(fetusRmostRatRriskRd/tRrapidRgrowth)



WhatRisRBEERSRcriteria?R-RCORRECTRANSWERR-
RecommendationsRofRmedicationsRinappropriateRforRelderlyR(65RandRolder),RprescriberRultimatelyRdecides



WhatRisRtheRCYP450R(cytochromeRP450)R-RCORRECTRANSWERR-
liverRenzymeRsystemRwhereRmedicationsRareRmetabolized,RcanReitherRbeRinducersRorRinhibitorsRandRcreate
Rdrug-drugRinteractions




CYP450RinducersR-RCORRECTRANSWERR-
SpeedRupRmetabolismRofRdrugsR(drugRisRclearedRfaster),RdrugRhasRlesserReffectR(decreaseRbloodRlevelsRofRdr
ug),RelevateRCYP450Renzymes



CYP450RinducersRpneumonicR-RCORRECTRANSWERR-"BullshitRCrapRGPSRINDUCESRrage"



CYP450RinducerRdrugRnamesR-RCORRECTRANSWERR-
Barbituates,RStRJohnRwort,RCarbamazepine,Rrifampin,Ralcohol,Rphenytoin,Rgriseofulvin,Rphenobarbital,Rsulf
onylureas



CYP450RinhibitorsR-RCORRECTRANSWERR-inhibitRmetabolism,RincreaseRbloodRlevelsRofRmedications



CYP450RpneumonicR-RCORRECTRANSWERR-
"VISARcreditRcardRdebtRINHIBITSRspendingRonRdesignersRlikeRCKRtoRlookRGQ"



CYP450RinhibitorsRdrugRnamesR-RCORRECTRANSWERR-
Valproate,Risoniazid,Rsulfonamides,Ramiodarone,Rchloramphenicol,Rketoconazole,RgrapefruitRjuice,Rquinidi
ne

,PhysiologicalRchangesRduringRpregnancyRthatRimpactRpharmacodynamicsRandRpharmacokineticRproperties
RofRdrugs?R-RCORRECTRANSWERR-increaseRglomerularRfiltrationRrateRleadsRtoRincreaseRdurgRexcretionR



increaseRhepaticRmetabolism

decreaseRtoneRandRmotilityRofRbowel

increaseRdrugRabsorption



ExamplesRofRmedicationsRthatRcanRbeRteratogenicR-RCORRECTRANSWERR-
AntiepilepticRdrugs,RantimicrobialsRsuchRasRtetracyclinesRandRfluoroquinolones,RvitaminRARinRlargeRdoses,Rs
omeRanticoagulants,RandRhormonalRmedicationsRsuchRasRdiethylstilbestrolR(DES).



HowRisRabsorptionRofRintramuscularRmedicationsRdifferentRinRneonates?R-RCORRECTRANSWERR-
slowRandRerraticRdueRtoRlowRbloodRflowRinRmusclesRfirstRfewRdaysRofRlife



WhyRisRabsorptionRofRmedicationRinRtheRstomachRincreasedRinRinfancy?R-RCORRECTRANSWERR-
delayedRgastricRemptying



SomeRmedicationsRthatRshouldRbeRavoidedRinRtheRpediatricRpatient?R-RCORRECTRANSWERR-
glucocorticoids,RdiscolorationRofRdevelopingRteethRwithRtetracyclines,RandRkernicterusRwithRsulfonamides,R
levofloxacinR(antibiotics)R

aspirinR(SevereRintoxicationRfromRacuteRoverdose)



whatRshouldRbeRincludedRinRmedicationRadministrationRpatientReducation?R-RCORRECTRANSWERR-
dosageRsizeRandRtiming

routeRandRtechniqueRofRadministration

durationRofRtreatment

drugRstorage

natureRandRtimeRcourseRofRdesiredRresponses

natureRandRtimeRcourseRofRadverseRresponses

finishRtakingRantibiotic



WhatRareRsomeRthingsRthatRputRtheRelderlyRpatientRatRhigherRriskRforRadverseRdrugRreactions?R-
RCORRECTRANSWERR-reducedRrenalRfunctionR

,polypharmacyR(theRuseRofRfiveRorRmoreRmedicationsRdaily)

greaterRseverityRofRillness

presenceRofRcomorbidities

useRofRdrugsRthatRhaveRaRlowRtherapeuticRindexR(e.g.,Rdigoxin)

increasedRindividualRvariationRsecondaryRtoRalteredRpharmacokinetics

inadequateRsupervisionRofRlong-termRtherapy

poorRpatientRadherence



HowRcanRhealthcareRprovidersRdecreaseRlikelihoodRofRanRelderlyRpatientRexperiencingRanRadverseRdrugRrea
ction?R-RCORRECTRANSWERR-obtainingRaRthoroughRdrugRhistoryRthatRincludesRover-the-
counterRmedications

consideringRpharmacokineticRandRpharmacodynamicsRchangesRdueRtoRage

monitoringRtheRpatient'sRclinicalRresponseRandRplasmaRdrugRlevels

usingRtheRsimplestRregimenRpossible

monitoringRforRdrug-drugRinteractionsRandRiatrogenicRillness

periodicallyRreviewingRtheRneedRforRcontinuedRdrugRtherapy

encouragingRtheRpatientRtoRdisposeRofRoldRmedications

takingRstepsRtoRpromoteRadherenceRandRtoRavoidRdrugsRonRtheRBeersRlist



HowRcanRweRpromoteRmedicationRadherenceRwithRelderlyRpatients?R-RCORRECTRANSWERR-
simplifyingRdrugRregimens

providingRclearRandRconciseRverbalRandRwrittenRinstructions

usingRanRappropriateRdosageRform

clearlyRlabelingRandRdispensingReasy-to-openRcontainers

developingRdailyRreminders

monitoringRfrequently

affordabilityRofRdrugs

supportRsystems

, WhyRdoRnitratesRneedRtoRbeRtakenRnoRlaterRthanR4RPM?R-RCORRECTRANSWERR-
NeedRnitrateRfreeRintervalRsoRtoleranceRdoesn'tRdevelop



NineRfactorsRthatRimpactRoutcomeRofRmedication?R-RCORRECTRANSWERR-GenderRandRrace

GeneticsRandRpharmacogenomics

VariabilityRinRabsorption

placeboReffect

Tolerance

patho

age

bodyweight



DoRyouRneedRinformedRconsentRforRgeneticRtesting?R-RCORRECTRANSWERR-yes



WhatRisRtheRpurposeRofRtheRGeneticRInformationRNon-DiscriminatoryRAct?R-RCORRECTRANSWERR-
ProtectsRpatientsRfromRdiscriminationRbyRemployersRandRinsuranceRprovidersRbasedRonRgeneticRinformatio
n



DifferenceRbetweenRpracticeRauthorityRandRprescriptiveRauthority?R-RCORRECTRANSWERR-
PracticeRauthorityRrefersRtoRtheRnurseRpractitioner'sRabilityRtoRpracticeRwithoutRphysicianRoversight,Rwhere
asRprescriptiveRauthorityRrefersRtoRtheRnurseRpractitioner'sRauthorityRtoRprescribeRmedicationsRindepende
ntlyRandRwithoutRlimitations.



WhoRregulatesRprescriptiveRauthority?R-RCORRECTRANSWERR-
theRjurisdictionRofRaRhealthRprofessionalRboard.RThisRmayRbeRtheRStateRBoardRofRNursing,RtheRStateRBoardR
ofRMedicine,RorRtheRStateRBoardRofRPharmacy,RasRdeterminedRbyReachRstate.



WhatRisRscopeRofRpracticeRdeterminedRby?R-RCORRECTRANSWERR-
isRdeterminedRbyRstateRpracticeRandRlicensureRlaws.



WhatRisRfullRpracticeRauthority?R-RCORRECTRANSWERR-
NurseRpractitionersRhaveRtheRautonomyRtoRevaluateRpatients,Rdiagnose,RorderRandRinterpretRtests,RinitiateR