ADVANCED HESI PHARMACOLOGY LATEST
UPDATE 2025 QUESTIONS AND ANSWERS
REVISED 100% CORRECT ALREADY
GRADED A+
_______________________________________
A female client with rheumatoid arthritis takes ibuprofen (Motrin) 600 mg PO 4 times a
day. To prevent gastrointestinal bleeding, misoprostol (Cytotec) 100 mcg PO is prescribed.
Which information is most important for the nurse to include in client teaching?
✓ Use contraception during intercourse.
A client with osteoarthritis receives a new prescription for celecoxib (Celebrex) orally for
symptom management. The nurse notes the client is allergic to sulfa. Which action is most
important for the nurse to implement prior to administering the first dose?
✓ Notify the healthcare provider.
A client is admitted to the hospital for a new onset of supraventricular tachycardia (SVT)
and is prescribed digoxin. For which laboratory finding should the nurse notify the
healthcare provider immediately?
✓ Potassium level of 3.1 mEq/L. C
The nurse is transcribing a new prescription for spironolactone (Aldactone) for a client
who receives an angiotensin-converting enzyme (ACE) inhibitor. Which action should the
nurse implement?
✓ Verify both prescriptions with the healthcare provider.
The nurse admits a client with tumor-induced spinal cord compression. Which medication
should the nurse anticipate to be prescribed to offer the best palliative treatment for this
client?
✓ Dexamethasone
,The nurse is preparing an education session for a client prescribed opioids for intractable
cancer pain. The nurse should include strategies to help prevent which common side
effect associated with long-term use of opioids?
✓ Constipation
A client is prescribed controlled-release oxycodone. Which dosing schedule is best for the
nurse to teach the client?
✓ Every 12 hours.
Which client should the nurse identify as being at highest risk for complications during the
use of an opioid analgesic?
✓ A young adult with inflammatory bowel disease.
Which medications should the nurse caution the client about taking while receiving an
opioid analgesic?
✓ Benzodiazepines.
A client is prescribed 1 mcg/kg/min of dobutamine hydrochloride via IV infusion. Which
client's condition would benefit the most from an administration of dobutamine
hydrochloride?
✓ Heart failure.
A client is experiencing anaphylaxis from an insect sting. Which medication should the
nurse administer?
✓ Epinephrine.
The healthcare provider prescribes a beta-1 agonist medication to be administered. The
nurse should anticipate the medication to be prescribed for a client diagnosed with which
condition?
✓ Heart failure.
,An older client with a decreased percentage of lean body mass is admitted to the hospital.
Which pharmacokinetic process is affected and should be considered in the client's dosing
of medication?
✓ Distribution.
A Category X drug is prescribed for a young adult female client. Which instruction is most
important for the nurse to teach this client?
✓ Use a reliable form of birth control.
A client being discharged home is prescribed an antibiotic with a dosage three times
higher than it was administered when the client was in the hospital. Which route of
administration should the nurse anticipate will be prescribed for the greatest first-pass
effect?
✓ Oral.
The healthcare provider prescribes naproxen (Naproxen) twice daily for a client with
osteoarthritis of the hands. The client tells the nurse that the drug does not seem to be
effective after three weeks. Which is the best response for the nurse to provide?
✓ Another type of nonsteroidal antiinflammatory drug may be indicated.
After abdominal surgery, a client is prescribed low molecular weight heparin (LMWH).
During administration of the medication, the client asks the nurse the reason for the
medication. Which is the best response for the nurse to provide the client?
✓ This medication is given to prevent blood clot formation.
A client with heart failure is prescribed spironolactone (Aldactone). Which information is
most important for the nurse to provide to the client about diet modifications?
✓ Refrain from eating foods high in potassium.
A client receiving doxorubicin (Adriamycin) intravenously (IV) complains of pain at the
insertion site, and the nurse notes edema at the site. Which intervention is most
important for the nurse to implement?
✓ Discontinue the IV fluids.
, A client with acute myocardial infarction is admitted to the coronary care unit. Which
medication should the nurse administer to lessen the workload of the heart by decreasing
the cardiac preload and afterload?
✓ Nitroglycerin.
Which instruction) should the nurse give to a female client who just received a
prescription for oral metronidazole (Flagyl) for treatment of trichomonas vaginalis? (Select
all that apply.)
✓ Increase fluid intake, especially cranberry juice.
- Avoid drinking alcohol while taking this medication.
- Use condoms until treatment is completed.
- Ensure that all sexual partners are treated at the same time.
A client with hyperlipidemia receives a prescription for niacin (Niaspan). Which client
teaching is most important for the nurse to provide?
✓ Expected duration of flushing.
The nurse is planning discharge instructions for a client prescribed cyclosporine following
a liver transplant. Which adverse reactions should the nurse instruct the client to report to
the healthcare provider?
✓ Presence of hand tremors.
A client is taking hydromorphone (Dilaudid) PO every 4 hours at home. Following surgery,
Dilaudid IV every 4 hours PRN and butorphanol tartrate (Stadol) IV every 4 hours PRN are
prescribed for pain. The client received a dose of the Dilaudid IV four hours ago, and is
again requesting pain medication. Which intervention should the nurse implement?
✓ Administer only the Dilaudid every 4 hours PRN for pain.
Which change in data indicates to the nurse that the desired effect of the angiotensin II
receptor antagonist valsartan has been achieved?
✓ Blood pressure reduced from 160/90 mmHg to 130/80 mmHg.
UPDATE 2025 QUESTIONS AND ANSWERS
REVISED 100% CORRECT ALREADY
GRADED A+
_______________________________________
A female client with rheumatoid arthritis takes ibuprofen (Motrin) 600 mg PO 4 times a
day. To prevent gastrointestinal bleeding, misoprostol (Cytotec) 100 mcg PO is prescribed.
Which information is most important for the nurse to include in client teaching?
✓ Use contraception during intercourse.
A client with osteoarthritis receives a new prescription for celecoxib (Celebrex) orally for
symptom management. The nurse notes the client is allergic to sulfa. Which action is most
important for the nurse to implement prior to administering the first dose?
✓ Notify the healthcare provider.
A client is admitted to the hospital for a new onset of supraventricular tachycardia (SVT)
and is prescribed digoxin. For which laboratory finding should the nurse notify the
healthcare provider immediately?
✓ Potassium level of 3.1 mEq/L. C
The nurse is transcribing a new prescription for spironolactone (Aldactone) for a client
who receives an angiotensin-converting enzyme (ACE) inhibitor. Which action should the
nurse implement?
✓ Verify both prescriptions with the healthcare provider.
The nurse admits a client with tumor-induced spinal cord compression. Which medication
should the nurse anticipate to be prescribed to offer the best palliative treatment for this
client?
✓ Dexamethasone
,The nurse is preparing an education session for a client prescribed opioids for intractable
cancer pain. The nurse should include strategies to help prevent which common side
effect associated with long-term use of opioids?
✓ Constipation
A client is prescribed controlled-release oxycodone. Which dosing schedule is best for the
nurse to teach the client?
✓ Every 12 hours.
Which client should the nurse identify as being at highest risk for complications during the
use of an opioid analgesic?
✓ A young adult with inflammatory bowel disease.
Which medications should the nurse caution the client about taking while receiving an
opioid analgesic?
✓ Benzodiazepines.
A client is prescribed 1 mcg/kg/min of dobutamine hydrochloride via IV infusion. Which
client's condition would benefit the most from an administration of dobutamine
hydrochloride?
✓ Heart failure.
A client is experiencing anaphylaxis from an insect sting. Which medication should the
nurse administer?
✓ Epinephrine.
The healthcare provider prescribes a beta-1 agonist medication to be administered. The
nurse should anticipate the medication to be prescribed for a client diagnosed with which
condition?
✓ Heart failure.
,An older client with a decreased percentage of lean body mass is admitted to the hospital.
Which pharmacokinetic process is affected and should be considered in the client's dosing
of medication?
✓ Distribution.
A Category X drug is prescribed for a young adult female client. Which instruction is most
important for the nurse to teach this client?
✓ Use a reliable form of birth control.
A client being discharged home is prescribed an antibiotic with a dosage three times
higher than it was administered when the client was in the hospital. Which route of
administration should the nurse anticipate will be prescribed for the greatest first-pass
effect?
✓ Oral.
The healthcare provider prescribes naproxen (Naproxen) twice daily for a client with
osteoarthritis of the hands. The client tells the nurse that the drug does not seem to be
effective after three weeks. Which is the best response for the nurse to provide?
✓ Another type of nonsteroidal antiinflammatory drug may be indicated.
After abdominal surgery, a client is prescribed low molecular weight heparin (LMWH).
During administration of the medication, the client asks the nurse the reason for the
medication. Which is the best response for the nurse to provide the client?
✓ This medication is given to prevent blood clot formation.
A client with heart failure is prescribed spironolactone (Aldactone). Which information is
most important for the nurse to provide to the client about diet modifications?
✓ Refrain from eating foods high in potassium.
A client receiving doxorubicin (Adriamycin) intravenously (IV) complains of pain at the
insertion site, and the nurse notes edema at the site. Which intervention is most
important for the nurse to implement?
✓ Discontinue the IV fluids.
, A client with acute myocardial infarction is admitted to the coronary care unit. Which
medication should the nurse administer to lessen the workload of the heart by decreasing
the cardiac preload and afterload?
✓ Nitroglycerin.
Which instruction) should the nurse give to a female client who just received a
prescription for oral metronidazole (Flagyl) for treatment of trichomonas vaginalis? (Select
all that apply.)
✓ Increase fluid intake, especially cranberry juice.
- Avoid drinking alcohol while taking this medication.
- Use condoms until treatment is completed.
- Ensure that all sexual partners are treated at the same time.
A client with hyperlipidemia receives a prescription for niacin (Niaspan). Which client
teaching is most important for the nurse to provide?
✓ Expected duration of flushing.
The nurse is planning discharge instructions for a client prescribed cyclosporine following
a liver transplant. Which adverse reactions should the nurse instruct the client to report to
the healthcare provider?
✓ Presence of hand tremors.
A client is taking hydromorphone (Dilaudid) PO every 4 hours at home. Following surgery,
Dilaudid IV every 4 hours PRN and butorphanol tartrate (Stadol) IV every 4 hours PRN are
prescribed for pain. The client received a dose of the Dilaudid IV four hours ago, and is
again requesting pain medication. Which intervention should the nurse implement?
✓ Administer only the Dilaudid every 4 hours PRN for pain.
Which change in data indicates to the nurse that the desired effect of the angiotensin II
receptor antagonist valsartan has been achieved?
✓ Blood pressure reduced from 160/90 mmHg to 130/80 mmHg.
