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ONS/ONCC Chemotherapy Immunotherapy Certificate New Study Set With 100% Verified Solutions!!

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ONS/ONCC Chemotherapy Immunotherapy Certificate New Study Set With 100% Verified Solutions!!...

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ONS/ONCC Chemotherapy Immunotherapy Certificate
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ONS/ONCC Chemotherapy Immunotherapy Certificate
Course
ONS/ONCC Chemotherapy Immunotherapy Certificate

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Uploaded on
January 29, 2025
Number of pages
31
Written in
2024/2025
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ONS/ONCC Chemotherapy Immunotherapy Certificate New
Study Set With 100% Verified Solutions!!


2025-2026 NEWEST



Lesson 1: Foundations to Set the Stage

Cellular Structure and Function - Focus



The Normal Cell Cycle - Answer >>-The cell cycle represents the ordered

series of processes of DNA replication and mitosis or cell division



-Cell nucleus supervises these processes through collection and processing complex
molecular information



Interphase and Mitotic Phase - Answer >>Cellular division produces two identical cells
through these two major phases



During interphase: - Answer >>Cell grows and DNA is replicated through the following
three steps:



1: First growth phase (G1 or first gap)



2: Synthesis phase (S phase)



3:Mitotic Phse (M phase)



First Growth Phase (G1 or first gap) - Answer >>-cells increase in size

,-reproduce RNA



-"quality assurance" test that the cell will be ready to synthesis DNA



-Length of time is variable, can be from hours to days



Synthesis Phase (S phase) - Answer >>-DNA replicates



-results in the formation of identical pairs of DNA (chromatids)



-which are attached a t the centromere



-lasts 2-10 hours



Mitotic Phase (M phase) - Answer >>-Replicated chromosomes are aligned, separated,
and move into 2 new, identical daughter cells



-takes about 30-60 minutes



Major points of cell regulation are entry and exit from - Answer >>-G1 checkpoint



-S Phase



-G2 checkpoint



-M phase

,Restriction Point - Answer >>-The point where a cell is in a resting phase to an actively
dividing phase G0-G1 is a point of cellular transformation



-Cell pass through a transition phase in this time known as restriction point



-Extracellular growth factors stimulate the reentry into G1 and GF are required for
sending the cells past the restriction point, or point of no return



G0 Phase-resting phase - Answer >>-Following mitosis, cells can re-enter the G1 phase
or enter a resting phase, called G0



-Most cells in the human body are resident in G0



-Exceptions to this include those that are (Resting in G0 phase) - Answer >>-Exceptions
to this include those that are metabollically active, such as



-granulocytes



-and the epithelium of the GI tract



Cell Cycling Time - Answer >>Time from mitosis to mitosis



Cell cycle video and image - Answer >>



http://highered.mheducation.com/sites/0072495855/student_view0/chapter2/animation_
_how_the_cell_cycle_works.html



Check points in the Cell Cycle: Keeping it All Under Control - Answer >>-The cell cycle is

, tightly regulated by a series of checkpoints



-Variation in duplication or distribution of chromosomes during cell division can alter the
genetic information passed on to daughter cells, leading to cellular dysfunction and
disease, such as cancer



-These checkpoints monitor for DNA integrity and control progression through mitosis



Progression through the cell cycle is controlled through two proteins: - Answer >>1.
cyclines (D, E, A, B)



2. Cyclin-dependent kinases (CDKs)



-Cyclin-CDK complex allows the cell to progress through each phase of the cell cycle



Locations of proteins Cyclins (D, E, A, B) and CDKs - Answer >>-(G0-G1) : Cyclin D and
CDK 4/6



-Early S: Cyclin E and CDK 1/2



-Late S: Cyclin A and CDK 1/2



-G2: CDK 1/2 and cyclin A



-Before M: CDK 1 and Cyclin B



Inhibitory proteins - Answer >>-stop the cycle from proceeding when DNA damage is
detected

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