10TH EDITION QUESTIONS & ANSWERS
Alpha 1 blockers - ANS-Drugs that primarily cause arterial and venous dilation through their action on
peripheral sympathetic neurons
Antihypertensive drugs - ANS-Medications used to treat hypertension
Cardiac output - ANS-The volume of blood ejected from the left side of the heart in one minute.
Centrally acting adrenergic drugs - ANS-Drugs that modify the function of the sympathetic nervous
system in the brain by stimulating alpha2 receptors. Alpha2 receptors are inhibitory in nature and thus
have a reverse sympathetic effect and cause decreased blood pressure.
Essential hypertension - ANS-elevated systemic arterial pressure of unknown cause that develops for no
apparent reason; sometimes called primary hypertension or idiopathic hypertension.
Hypertension - ANS-often asymptomatic disorder. anything greater than 130/80mm Hg. (Therapy should
start if systolic b/p exceeds 150mm Hg and or diastolic exceeds 90mm Hg in patients over 60years old
and 140/90 for patients younger than 60 and those who have chronic kidney disease or diabetes.)
Orthostatic hypotension - ANS-A common adverse effect of adrenergic-blocking drugs involving a
sudden drop in blood pressure when a person changes position, especially when rising from a seated or
horizontal position.
Prodrug - ANS-A drug that is inactive in its given form and must be metabolized to its active form in the
body, generally by the liver, to be effective.
Secondary hypertension - ANS-high blood pressure caused by the effects of another disease, such as
renal, pulmonary, endocrine, or vascular disease.
7 main categories of pharmacologic drugs to treat hypertension - ANS-Adrenergic drug
Angiotensin converting Enzyme inhibitors (ACE)
Angiotensin II receptor blockers
calcium channel blockers
diuretics
vasodilators
direct renin inhibitors
Adrenergic subcategories - ANS-- Centrally and peripheral acting adrenergic neuron blockers