ABSITE questions and answers with solutions 2025

ABSITE questions and answers with
solutions 2025
2 weeks after a whipple operation, your patient continues to have early satiety with oral intake.
O O O O O O O O O O O O O O O O



You decide to start metoglopramide (Reglan) and erythromycin. What receptor does erythromyc
O O O O O O O O O O O



in bind to increase gastrointestinal motility? -
O O O O O O



OANSWER Motilin (found primarily in the stomach, duodenum, and colon)
O O O O O O O O O




Proteins are synthesized from: O O O




a. mRNA O




b. tRNA O




c. dsDNA
O




d. ssDNA - ANSWER mRNA
O O O O




1 week after an APR, our patient develops urosepsis requiring volume resuscitation, antibiotics,
O O O O O O O O O O O O O



and moderate amounts of levophed and vasopressin. E. coli grows out from the blood cultures.
O O O O O O O O O O O O O O O



What portion of the lipopolysaccharide complex accounts for its toxicity -
O O O O O O O O O O



ANSWER Lipid A (with gram negative sepsis; stimulator of TNFα)
O O O O O O O O O O




Steroid hormones: O




a. Bind a receptor on the plasma membrane and activate a plasma membrane enzyme
O O O O O O O O O O O O O




b. Bind a cytoplasmic receptor, enter the nucleus, and affect transcription of proteins
O O O O O O O O O O O O




c. Bind a receptor in the nucleus and affect transcription of proteins
O O O O O O O O O O O




d. Do not enter the cell - ANSWER (b)
O O O O O O O O




Bind a receptor in the cell cytoplasm, enter the nucleus as a steroid-
O O O O O O O O O O O O



receptor complex, and affect transcription of proteins
O O O O O O

,4 days after an Ivor-Lewis esophagectomy, you decide to start enteral tube feeding through a J-
O O O O O O O O O O O O O O O



tube. The long chain fatty acids contained in the tube feeds:
O O O O O O O O O O




a. Enter the circulation via the portal system
O O O O O O O




b. Enter the circulation via lymphatics
O O O O O




c. Are only synthesized in the body
O O O O O O




d. Are not found in chylomicrons - ANSWER (b)
O O O O O O O O




Long-
chain FAs enter the body through terminal lacteals (absorption through the lymphatic system) ei
O O O O O O O O O O O O O



ther as free LCFAs or as chylomicrons
O O O O O O




Medium- and short-chain FAs along with proteins/CHO enter through the portal circulation
O O O O O O O O O O O




Cells divide during what phase of the cell cycle?
O O O O O O O O




a. G1O




b. S O




c. G2
O




d. M - ANSWER (d)
O O O O




Cells divide during the M phase (most radiosensitive)
O O O O O O O




Cell cycle length is determined by what phase of the cell cycle?
O O O O O O O O O O O




a. G1O

,b. S
O




c. G2
O




d. M - ANSWER (a)
O O O O




G1 ↔ G0 phase determines cell cycle length (most variable cell period)
O O O O O O O O O O O




Most RNA/protein synthesis
O O




Of the following, which is the most critical component in the neovascularization of tumor metas
O O O O O O O O O O O O O O



tases?



a. HER receptor
O O




b. VEGF receptor
O O




c. Neu receptor
O O




d. FGF receptor - ANSWER (d)
O O O O O




Vascular endothelial growth factor (VEGF) receptor
O O O O O




For its anticoagulation effects, heparin binds:
O O O O O




a. Protein C
O O




b. Protein S
O O




c. Anti-thrombin III
O O




d. Factor VII - ANSWER (c)
O O O O O




ATIII (heparin-ATIII complex binds thrombin, factor IX, factor X, and factor XI)
O O O O O O O O O O O

, 7 days after a kidney transplant, your patient develops severe acute rejection with vasculitis on
O O O O O O O O O O O O O O O



biopsy. You decide to start the monoclonal antibody OKT3. Monoclonal antibodies:
O O O O O O O O O O




a. Bind 1 epitope at one site
O O O O O O




b. Bind 1 epitope at multiple sites
O O O O O O




c. Bind multiple epitopes on a single antigen
O O O O O O O




d. Bind multiple epitopes on multiple antigens - ANSWER (a)
O O O O O O O O O




They bind one epitope at the exact same binding site
O O O O O O O O O




You start coumadin on a patient with a pulmonary embolus. Three days later, he starts sloughing
O O O O O O O O O O O O O O O



Ooff skin across his arms and legs. All of the following are true of this patients most likely conditio
O O O O O O O O O O O O O O O O O O



n except:
O




a. This likely would have been prevented by starting heparin before coumadin
O O O O O O O O O O O




b. Patients with protein C deficiency are more susceptible to this problem
O O O O O O O O O O O




c. The skin sloughing is caused by skin necrosis
O O O O O O O O




d. This is likely due to hemophilia A - ANSWER (d)
O O O O O O O O O O




Coumadin-
induced skin necrosis occurs in patients started on coumadin without being given heparin first. I
O O O O O O O O O O O O O O



t results from a relatively hypercoagulable state that can occur in some individuals because of th
O O O O O O O O O O O O O O O



e shorter half-
O O



life of protein C & S compared to factors II, VII, IX, and X. Protein C & S ↓ after coumadin before
O O O O O O O O O O O O O O O O O O O O O O



the other factors ↓, resulting in a relatively hypercoagulable state.
O O O O O O O O O