Drug receptors - Answers Usually proteins. How is the body effected by protein
Ion channel receptors - Answers Rapid onset and short duration such as nicotine and gaba
G proteins - Answers Proteins that cross the cell membrane- creates a pocket where drugs can interact
Transmembrane receptors - Answers Extracellular hormone binding domain that phosphorylated the
amino acid tyrosine- insulin receptors
Intracellular receptors - Answers Regulating gene expression- lipid soluble hormones that can pass
through the cell membrane and bind to intracellular receptors (thyroid)
Enzymes - Answers Biological molecules that encourage chemical reactions (antibiotics)
To work medications have to bind to - Answers A protein or a enzyme
Agonist/ full agonist - Answers Drugs the produce receptor stimulation and a conformational change
every time they bind. Do not need all available receptors to produce a maximum response (example
opiates)
Antagonist - Answers Drugs that occupy receptor without stimulating them. Occupy the receptor site
and prevent other molecules from occupation of the same sits. Example- beta blocker
Partial agonists - Answers Properties of agonist and antagonists example buprenorphine
Pharmacokinetics - Answers The branch of pharmacology that deals with absorption distribution
metabolism and excretion of drugs
Absorption - Answers The speed extent and duration of drug absorption
Greatest route for absorption - Answers IV
Most convienant route of absorption - Answers Oral medication for GI absorption- metabolized by liver
Bioavailability - Answers The percentage of the administered dose that is able to enter the blood stream
need to have narrow therapeutic window
Distribution - Answers The process of the drug moving through the body
Distribution is effected by - Answers Protein binding
Transport system membrane proteins
Volume distribution to reflect the volume of drug needing to be dissolved
Metabolism - Answers Chemically altered by enzymes into new molecules called metabolites