Pharmacology KNES 4121 - Exam 1
Study Guide Questions And Actual
Answers.
Pharmacology - Answer Study of drugs and their physiological actions on living organisms
Pharmacologist - Answer Studies physiological responses and adaptions to drugs
Studies response to pharmacological agent
Pharmacological Enhance/Inhibit Sports - Answer Steroids, amphetamines act physiologically
Beta blockers inhibit performance
Contraindication for physical activity - Answer Beta blockers decrease heart rate when increase is
necesary
Chinese Pharmacology - Answer Oldest form
Originally developed to understand physiological mechanisms
Francois Megendie - Answer 1809 - First pharmacologist
Studied nux vomica reaction on dogs, found convulsions came from the spinal cord linking muscle
contractions and the nervous system
Claude Bernard - Answer 1847 - Discovered curare prevents neuromuscular junctions from firing
Rudolf Buchheim - Answer 1874 - First University chair of pharmacology
Oswalk Schmiedeburd - Answer Considered founder of modern pharmacology
John Abel - Answer First US pharmacology chair at University of Michigan
, Drug Development - Answer Takes 7-12 years
Involves US FDA, multiple phases (4)
US FDA - Answer United States Food & Drug Administration
Regulates development of new drugs, approves for market use, and monitors effects of drugs after
market
Pre-FDA Phase - Answer Chemist develops compound
Tests on cell cultures with targeted disease
Includes animal testing post-positive lab results (Institutional Animal Care approval)
Starts with in-vivo & lab animal studies
IND Phase I - Answer 4-6 week trail of 20-100 healthy human
Unaffected, healthy, "normal" volunteers
IND Phase II - Answer Trails with specific disease target
Analyze effective vs. toxicity
IND Phase III - Answer 2-10 years (5 years average)
Includes testing on large populations to gather feedback of adverse effects
NDA - Answer New Drug Application
2 year processing
Can be rejected by FDA
Orphan Drug Act - Answer Helps companies develop drugs to cure rare qualities of disease
Protects companies for development of rare disease cure
Study Guide Questions And Actual
Answers.
Pharmacology - Answer Study of drugs and their physiological actions on living organisms
Pharmacologist - Answer Studies physiological responses and adaptions to drugs
Studies response to pharmacological agent
Pharmacological Enhance/Inhibit Sports - Answer Steroids, amphetamines act physiologically
Beta blockers inhibit performance
Contraindication for physical activity - Answer Beta blockers decrease heart rate when increase is
necesary
Chinese Pharmacology - Answer Oldest form
Originally developed to understand physiological mechanisms
Francois Megendie - Answer 1809 - First pharmacologist
Studied nux vomica reaction on dogs, found convulsions came from the spinal cord linking muscle
contractions and the nervous system
Claude Bernard - Answer 1847 - Discovered curare prevents neuromuscular junctions from firing
Rudolf Buchheim - Answer 1874 - First University chair of pharmacology
Oswalk Schmiedeburd - Answer Considered founder of modern pharmacology
John Abel - Answer First US pharmacology chair at University of Michigan
, Drug Development - Answer Takes 7-12 years
Involves US FDA, multiple phases (4)
US FDA - Answer United States Food & Drug Administration
Regulates development of new drugs, approves for market use, and monitors effects of drugs after
market
Pre-FDA Phase - Answer Chemist develops compound
Tests on cell cultures with targeted disease
Includes animal testing post-positive lab results (Institutional Animal Care approval)
Starts with in-vivo & lab animal studies
IND Phase I - Answer 4-6 week trail of 20-100 healthy human
Unaffected, healthy, "normal" volunteers
IND Phase II - Answer Trails with specific disease target
Analyze effective vs. toxicity
IND Phase III - Answer 2-10 years (5 years average)
Includes testing on large populations to gather feedback of adverse effects
NDA - Answer New Drug Application
2 year processing
Can be rejected by FDA
Orphan Drug Act - Answer Helps companies develop drugs to cure rare qualities of disease
Protects companies for development of rare disease cure
