CSCC Pharmacology: Exam 1 (review for final) UPDATED Exam Questions and CORRECT Answers

CSCC Pharmacology: Exam 1 (review for
final) UPDATED Exam Questions and
CORRECT Answers
plasma half life (T1/2) - CORRECT ANSWER - descriptive of duration
-time for concentration of a med to decrease by one half


increased T1/2 =? - CORRECT ANSWER - increased excretion time = increased duration
of effects


onset - CORRECT ANSWER - time it takes to produce therapeutic effects



therapeutic range - CORRECT ANSWER - between minimum effective serum
concentration and toxic serum concentration


factors effecting excretion - CORRECT ANSWER - -decreased renal or hepatic function
-blood flow
-ionization
-lipid solubility
-drug protein complexes
-metabolic activity
-pH
-resp, glandular, or biliary activity


first pass effect - CORRECT ANSWER - oral drugs reach hepatic portal system prior to
reaching target tissue and may be inactivated


prodrug - CORRECT ANSWER - drug that is activated by being metabolized (i.e. losartin,
benazepril)

, hepatic microsomal enzyme system (p450-system) - CORRECT ANSWER - inactivates
drugs and accelerates excretion
**anything that effects this system effects drug metabolism**


primary site of drug metabolism - CORRECT ANSWER - liver



what drugs don't cross the blood-brain barrier easily? - CORRECT ANSWER - antitumor
drugs


what drugs DO cross the blood-brain barrier? - CORRECT ANSWER - -sedatives
-anticonvulsants
-antanxiety


displacement - CORRECT ANSWER - drug shifts another from a binding site and alters
effect
1A + 2 = 1 + 2A


antagonism - CORRECT ANSWER - causes a blocked or opposite effect
1+1=0 OR 1+1=-2


synergism - CORRECT ANSWER - action is more than total effect
1+1=4


addition - CORRECT ANSWER - action as total
1+1=2


factors that influence distribution - CORRECT ANSWER - -lipid solubility