PCB 4233 Immunology Final Exams Need to
Study Questions and Correct Answers-
P region nucleotides - ✔✔caused by cutting of hairpin loop and the evening up
N region nucleotides - ✔✔up to 15 nucleotides at cut ends of V, D, J coding regions
by deoxynucleotidyl transferase
Somatic hypermutation - ✔✔
Combinatorial association of heavy and light chains - ✔✔when they combine it
changes the antigen being bound
Junctional Flexibility - ✔✔productive rearrangements
nonproductive rearrangements
Rag cuts precisely
artemis cuts randomly
Pre-B cell lines - ✔✔
Coding joints - ✔✔Vk21Jk1
Signal joints - ✔✔RSS/RSS
Epitope - ✔✔clonal selection
, Hapten - ✔✔number of clones activated is very small
T1D - ✔✔T cells recognize insulin or factors as insulin
Uveitis? - ✔✔B + T cells
recognize things associated with eye
Lupus - ✔✔B cells that recognize nucleic acid as or proteins assciated with nucleic
acid
Immunology - ✔✔protein protein interactions
Allelic exclusion - ✔✔B cells, like all somatic cells, are diploid- expresses rearranged
heavy gene from only one chromosome and rearranged light from only one
chromosome (the exclusion)
ensures only one functional VDJ and VJ unit in B cells
Is thought that once a successful VDJ and VJ occurs, recombination machinery is turned
off
Ig diversity between species - ✔✔humans and mice undergo similar diversity
processes in bone marrow
in birds, rabbits, sheep, cattle most of B cell development occurs in GALT
utilize one or a few rearrangements of germline VDJ genes
somatic hyper mutation or gene conversion is used to extensively diversify the
rearranged genes
Study Questions and Correct Answers-
P region nucleotides - ✔✔caused by cutting of hairpin loop and the evening up
N region nucleotides - ✔✔up to 15 nucleotides at cut ends of V, D, J coding regions
by deoxynucleotidyl transferase
Somatic hypermutation - ✔✔
Combinatorial association of heavy and light chains - ✔✔when they combine it
changes the antigen being bound
Junctional Flexibility - ✔✔productive rearrangements
nonproductive rearrangements
Rag cuts precisely
artemis cuts randomly
Pre-B cell lines - ✔✔
Coding joints - ✔✔Vk21Jk1
Signal joints - ✔✔RSS/RSS
Epitope - ✔✔clonal selection
, Hapten - ✔✔number of clones activated is very small
T1D - ✔✔T cells recognize insulin or factors as insulin
Uveitis? - ✔✔B + T cells
recognize things associated with eye
Lupus - ✔✔B cells that recognize nucleic acid as or proteins assciated with nucleic
acid
Immunology - ✔✔protein protein interactions
Allelic exclusion - ✔✔B cells, like all somatic cells, are diploid- expresses rearranged
heavy gene from only one chromosome and rearranged light from only one
chromosome (the exclusion)
ensures only one functional VDJ and VJ unit in B cells
Is thought that once a successful VDJ and VJ occurs, recombination machinery is turned
off
Ig diversity between species - ✔✔humans and mice undergo similar diversity
processes in bone marrow
in birds, rabbits, sheep, cattle most of B cell development occurs in GALT
utilize one or a few rearrangements of germline VDJ genes
somatic hyper mutation or gene conversion is used to extensively diversify the
rearranged genes
