Advanced Pharm: Antibiotics & Antiinfectives | UPDATE| COMPLETE
FREQUENTLY TESTED QUESTIONS WITH VERIFIED ANSWERS|GET IT
100% ACCURATE!!
Which patient ethnic ancestry creates a risk factor that may result in minimal
beneficial response to tamoxifen therapy?
a. African
b. French
c. Native American
d. Japanese - ANSWER-ANS: B
b. French
Between 8% & 10% of women of European ancestry have a gene variant that
prevents the effective metabolism of tamoxifen that negatively affects the
medication's therapeutic effect. None of the other options present with a similar
risk factor.
. Before initiating cetuximab therapy, the provider will order epidermal growth
factor receptor (EGFR) testing for the patient having which condition?
a. Breast cancer
,b. Colorectal cancer
c. Bone cancer
d. Brain cancer - ANSWER-ANS: B
b. Colorectal cancer
Cetuximab is used mainly for metastatic colorectal cancer. The medication works
only against tumors that express EGRF; all other tumors are unresponsive. This
makes testing in advance of treatment required. Cetuximab is not appropriate for
any of the other conditions listed.
. An infant developed a pruritic rash following exposure to an allergen. The infant's
parents ask the provider about using a topical antihistamine. What information
should the provider use to address the parents' question?
a. Antihistamines given by this route are not absorbed as well in children.
b. Applying an antihistamine to the skin can cause toxicity in this age group.
c. The child will also need oral medication to achieve effective results.
d. Topical medications have fewer side effects than those given by other routes. -
ANSWER-ANS: B
b. Applying an antihistamine to the skin can cause toxicity in this age group.
Drug absorption through the skin is more rapid in infants, because their skin is
thinner & has greater blood flow; therefore, infants are at increased risk of
,toxicity from topical drugs. Because of increased drug absorption through the
skin, infants should not be given additional drugs via other routes. If a drug is
more likely to be absorbed rapidly, it will have more side effects.
3. A patient is prescribed metronidazole for bacterial vaginosis. Which patient
history finding would be most concerning to the provider?
a. The patient had a recent yeast infection.
b. There is a family history of cervical cancer.
c. The patient drinks two glasses of wine every night.
d. The patient is unemployed. - ANSWER-ANS: C. The patient drinks two glasses of
wine every night.
Patients taking metronidazole should be educated not to drink alcohol to prevent a
disulfiram-like reaction. It would be concerning that the patient drinks wine daily.
History of a yeast infection may indicate increased risk for recurrence with
administration of an antimicrobial. A family history of cervical cancer is not
related to administration of metronidazole. Unemployment can indicate lack of
insurance coverage, which may limit the patient's ability to purchase medications;
however, generic metronidazole is one of the less expensive medications.
, 5. A patient receiving intravenous gentamicin has a toxic serum drug level. The
prescriber confirms that the dosing is correct. Which possible cause of this
situation will the provide explore?
a. Whether a loading dose was administered
b. If the drug was completely dissolved in the IV solution
c. Whether patient is taking a medication that binds to serum albumin
d. If the ordered dose frequency is longer than the gentamicin half-life - ANSWER-
ANS: C
c. Whether patient is taking a medication that binds to serum albumin
Gentamicin binds to albumin, but only weakly, & in the presence of another drug
that binds to albumin, it can rise to toxic levels in blood serum. A loading dose
increases the initial amount of a drug & is used to bring drug levels to the desired
plateau more quickly. A drug that is not completely dissolved carries a risk of
causing embolism but this addresses a different concern. A drug given at a
frequency longer than the drug half-life will likely be at subtherapeutic levels &
not at toxic levels.
10. A patient who has been taking sertraline for depression was prescribed
azithromycin to treat an infection by a provider at an after-hours clinic. What
action will the primary care provider take to address the risk this combination of
medication has posed for the patient?
FREQUENTLY TESTED QUESTIONS WITH VERIFIED ANSWERS|GET IT
100% ACCURATE!!
Which patient ethnic ancestry creates a risk factor that may result in minimal
beneficial response to tamoxifen therapy?
a. African
b. French
c. Native American
d. Japanese - ANSWER-ANS: B
b. French
Between 8% & 10% of women of European ancestry have a gene variant that
prevents the effective metabolism of tamoxifen that negatively affects the
medication's therapeutic effect. None of the other options present with a similar
risk factor.
. Before initiating cetuximab therapy, the provider will order epidermal growth
factor receptor (EGFR) testing for the patient having which condition?
a. Breast cancer
,b. Colorectal cancer
c. Bone cancer
d. Brain cancer - ANSWER-ANS: B
b. Colorectal cancer
Cetuximab is used mainly for metastatic colorectal cancer. The medication works
only against tumors that express EGRF; all other tumors are unresponsive. This
makes testing in advance of treatment required. Cetuximab is not appropriate for
any of the other conditions listed.
. An infant developed a pruritic rash following exposure to an allergen. The infant's
parents ask the provider about using a topical antihistamine. What information
should the provider use to address the parents' question?
a. Antihistamines given by this route are not absorbed as well in children.
b. Applying an antihistamine to the skin can cause toxicity in this age group.
c. The child will also need oral medication to achieve effective results.
d. Topical medications have fewer side effects than those given by other routes. -
ANSWER-ANS: B
b. Applying an antihistamine to the skin can cause toxicity in this age group.
Drug absorption through the skin is more rapid in infants, because their skin is
thinner & has greater blood flow; therefore, infants are at increased risk of
,toxicity from topical drugs. Because of increased drug absorption through the
skin, infants should not be given additional drugs via other routes. If a drug is
more likely to be absorbed rapidly, it will have more side effects.
3. A patient is prescribed metronidazole for bacterial vaginosis. Which patient
history finding would be most concerning to the provider?
a. The patient had a recent yeast infection.
b. There is a family history of cervical cancer.
c. The patient drinks two glasses of wine every night.
d. The patient is unemployed. - ANSWER-ANS: C. The patient drinks two glasses of
wine every night.
Patients taking metronidazole should be educated not to drink alcohol to prevent a
disulfiram-like reaction. It would be concerning that the patient drinks wine daily.
History of a yeast infection may indicate increased risk for recurrence with
administration of an antimicrobial. A family history of cervical cancer is not
related to administration of metronidazole. Unemployment can indicate lack of
insurance coverage, which may limit the patient's ability to purchase medications;
however, generic metronidazole is one of the less expensive medications.
, 5. A patient receiving intravenous gentamicin has a toxic serum drug level. The
prescriber confirms that the dosing is correct. Which possible cause of this
situation will the provide explore?
a. Whether a loading dose was administered
b. If the drug was completely dissolved in the IV solution
c. Whether patient is taking a medication that binds to serum albumin
d. If the ordered dose frequency is longer than the gentamicin half-life - ANSWER-
ANS: C
c. Whether patient is taking a medication that binds to serum albumin
Gentamicin binds to albumin, but only weakly, & in the presence of another drug
that binds to albumin, it can rise to toxic levels in blood serum. A loading dose
increases the initial amount of a drug & is used to bring drug levels to the desired
plateau more quickly. A drug that is not completely dissolved carries a risk of
causing embolism but this addresses a different concern. A drug given at a
frequency longer than the drug half-life will likely be at subtherapeutic levels &
not at toxic levels.
10. A patient who has been taking sertraline for depression was prescribed
azithromycin to treat an infection by a provider at an after-hours clinic. What
action will the primary care provider take to address the risk this combination of
medication has posed for the patient?
