Ace DD II Mock Exam 1: Study Guide and Review
Which of the following are related to drug particle size with oral dosage form - correct answer ✔✔-
uniformity of dug dosage content in each dosage form
-properties such as taste, color, and texture of the medicine
-bioavailability
-flow rates of powder mixtures in manufacture machines
-drug dissolution rate
Which of the following statements is/are about drug product recall - correct answer ✔✔all of the above
which of the following may be the rate limiting step from drug absorption from orally, administered drug
product - correct answer ✔✔-disintegration of the unit
-dissolution of the active drug
-diffusion of the active drug through the intestinal wall
True or false: current good manufacturing practice regulations are established by the Food and Drug
Administration (FDA) to ensure that minimum standards are met for drug product quality in the United
States - correct answer ✔✔True
Requirements for drug products to be considered pharmaceutical alternatives includes having the same -
correct answer ✔✔active drug and precursor
Reducing drug particles to enhance drug absorption is limited to those in which the: - correct answer
✔✔absorption process is the rate-limiting step by the dissolution of the drug in GI fluids
All of the following are stability problems associated with hard gelatin capsules except - correct answer
✔✔permeation of active drugs into capsule shell
True/false: Stability is the capacity of a drug product to remain within specifications established to
ensure its identity, strenght, quality and purity - correct answer ✔✔true
,Which of the following is/are used in pharmaceutical preparations as excipient? - correct answer ✔✔All
of the above
Which of the following is not used in pharmaceutical preparations as a sweetening agent - correct
answer ✔✔Lactose
Geometric dilution of a drug powder is intended to - correct answer ✔✔ensure homogenous drug
distribution
All of the following are physical-chemical factors that favor the diffusion of a drug across mammalian
membranes except - correct answer ✔✔Hydration of ionized drugs
Bioavailability data are used to determine all of the following except: - correct answer ✔✔The
palatability of a drug in different dosage
Which of the following are factors that a pharmacist must consider when determining a dosage regiment
for a specific patient? SATA - correct answer ✔✔All of the above
Which of the following are modes of action of preservatives of some dosage forms - correct answer ✔✔-
oxidation of cellular constituents
-modification of cell membrane permeability
-lysis and cytoplasmic leakage
-inhibition of cellular metabolism
Which of the following process(es) is/are related to passive diffusion? - correct answer ✔✔-the passage
of (drug) molecules through a membrane that does not actively participate in the process
-Passive absorption
-Fick's first law
-Absorption process is diven by concentration gradient of drug across the membrane
, Which of the following powders will not be liquefied upon absorption of moisture - correct answer ✔✔-
efflorescent, hygroscopic, dusting, dusting and hygroscopic
Which of the following is/are evidence of instability of solid dosage forms? - correct answer ✔✔all of the
above
Which of the following may occur during Phase 1 clinical trials of a prospective new drug? SATA - correct
answer ✔✔-testing in human beings for drug safety
-evaluating side effects associated with increasing doses
-selecting from among different chemical analogs of a lead compound
Which of the following phases for clinical testing is the final formulation usually developed - correct
answer ✔✔phase 2
Which of the following statements is/are true regarding drug metabolism? - correct answer ✔✔.-May
take place in the liver, kidney, lungs, and gastrointestinal tract
-Involves the biochemical transformation of drug substance -Some new drugs have been discovered as
metabolites of other processes
-Specific and nonspecific enzymes participate in the metabolic process
.Which of the following is/are toxicological profile(s) for drugs? - correct answer ✔✔-carcinogenicity
-chronic adverse effect
-reproduction studies
-genotoxicity or mutagenicity studies
. True/False: Drugs intended for the treatment of "rare diseases and conditions" may be designated as
orphan drugs to help promote research on rare diseases. - correct answer ✔✔true
All of the following are powder blending methods except: - correct answer ✔✔Levigation
Which of the following are related to drug particle size with oral dosage form - correct answer ✔✔-
uniformity of dug dosage content in each dosage form
-properties such as taste, color, and texture of the medicine
-bioavailability
-flow rates of powder mixtures in manufacture machines
-drug dissolution rate
Which of the following statements is/are about drug product recall - correct answer ✔✔all of the above
which of the following may be the rate limiting step from drug absorption from orally, administered drug
product - correct answer ✔✔-disintegration of the unit
-dissolution of the active drug
-diffusion of the active drug through the intestinal wall
True or false: current good manufacturing practice regulations are established by the Food and Drug
Administration (FDA) to ensure that minimum standards are met for drug product quality in the United
States - correct answer ✔✔True
Requirements for drug products to be considered pharmaceutical alternatives includes having the same -
correct answer ✔✔active drug and precursor
Reducing drug particles to enhance drug absorption is limited to those in which the: - correct answer
✔✔absorption process is the rate-limiting step by the dissolution of the drug in GI fluids
All of the following are stability problems associated with hard gelatin capsules except - correct answer
✔✔permeation of active drugs into capsule shell
True/false: Stability is the capacity of a drug product to remain within specifications established to
ensure its identity, strenght, quality and purity - correct answer ✔✔true
,Which of the following is/are used in pharmaceutical preparations as excipient? - correct answer ✔✔All
of the above
Which of the following is not used in pharmaceutical preparations as a sweetening agent - correct
answer ✔✔Lactose
Geometric dilution of a drug powder is intended to - correct answer ✔✔ensure homogenous drug
distribution
All of the following are physical-chemical factors that favor the diffusion of a drug across mammalian
membranes except - correct answer ✔✔Hydration of ionized drugs
Bioavailability data are used to determine all of the following except: - correct answer ✔✔The
palatability of a drug in different dosage
Which of the following are factors that a pharmacist must consider when determining a dosage regiment
for a specific patient? SATA - correct answer ✔✔All of the above
Which of the following are modes of action of preservatives of some dosage forms - correct answer ✔✔-
oxidation of cellular constituents
-modification of cell membrane permeability
-lysis and cytoplasmic leakage
-inhibition of cellular metabolism
Which of the following process(es) is/are related to passive diffusion? - correct answer ✔✔-the passage
of (drug) molecules through a membrane that does not actively participate in the process
-Passive absorption
-Fick's first law
-Absorption process is diven by concentration gradient of drug across the membrane
, Which of the following powders will not be liquefied upon absorption of moisture - correct answer ✔✔-
efflorescent, hygroscopic, dusting, dusting and hygroscopic
Which of the following is/are evidence of instability of solid dosage forms? - correct answer ✔✔all of the
above
Which of the following may occur during Phase 1 clinical trials of a prospective new drug? SATA - correct
answer ✔✔-testing in human beings for drug safety
-evaluating side effects associated with increasing doses
-selecting from among different chemical analogs of a lead compound
Which of the following phases for clinical testing is the final formulation usually developed - correct
answer ✔✔phase 2
Which of the following statements is/are true regarding drug metabolism? - correct answer ✔✔.-May
take place in the liver, kidney, lungs, and gastrointestinal tract
-Involves the biochemical transformation of drug substance -Some new drugs have been discovered as
metabolites of other processes
-Specific and nonspecific enzymes participate in the metabolic process
.Which of the following is/are toxicological profile(s) for drugs? - correct answer ✔✔-carcinogenicity
-chronic adverse effect
-reproduction studies
-genotoxicity or mutagenicity studies
. True/False: Drugs intended for the treatment of "rare diseases and conditions" may be designated as
orphan drugs to help promote research on rare diseases. - correct answer ✔✔true
All of the following are powder blending methods except: - correct answer ✔✔Levigation
