STEREOCHEMISTRY
, STEREOCHEMISTRY
• A branch of chemistry concerned
with the 3-dimensional aspect of
molecules.
• In many occasions, the 3-
dimensional structure is often
crucial to determine its properties
and biological behavior.
, Conformers
• Conformation- Different arrangement of atoms resulting from
rotation.
• Molecules that have different arrangements are
conformational isomers or conformers.
• Conformations can be represented in 2 ways:
i. Sawhorse representation – view C-C bond from an oblique an
indicate spatial orientation by showing all C-H bonds
3
, i. Newman representation- view C-C bond directly end-on
represent the front carbon by a dot and the rear (back) carb
by a circle.
2 projections possible
-Staggered- most stable: all 6 C-H bonds are as far away from e
other as possible
-Eclipsed- least stable: all 6 C-H bonds are as close as possible to e
other
, STEREOCHEMISTRY
• A branch of chemistry concerned
with the 3-dimensional aspect of
molecules.
• In many occasions, the 3-
dimensional structure is often
crucial to determine its properties
and biological behavior.
, Conformers
• Conformation- Different arrangement of atoms resulting from
rotation.
• Molecules that have different arrangements are
conformational isomers or conformers.
• Conformations can be represented in 2 ways:
i. Sawhorse representation – view C-C bond from an oblique an
indicate spatial orientation by showing all C-H bonds
3
, i. Newman representation- view C-C bond directly end-on
represent the front carbon by a dot and the rear (back) carb
by a circle.
2 projections possible
-Staggered- most stable: all 6 C-H bonds are as far away from e
other as possible
-Eclipsed- least stable: all 6 C-H bonds are as close as possible to e
other
